Compression and Expansion of Circadian Rhythm in Mice Under Long and Short Photoperiods

Although the functional aspects of synchronization of the circadian pacemaker by environmental light have been extensively studied, few studies have provided systematic information about the temporal organization of behavior under light-dark cycles with varying proportions of light and darkness. In the present study, the running-wheel activity profiles of mice were investigated under short, medium, and long photoperiods. The results clearly indicated that the temporal distribution of locomotor activity in mice is modulated by photoperiod. The activity profile was compressed under long photoperiods and expanded under short photoperiods. Although negative masking by light and alterations in the state of dark adaptation may have partially accounted for the phenomenon, the major mechanism seemed to be a compression and expansion of the circadian pacemaker's cycle, as expressed in the compression and expansion of the photic phase-response curve.     

Reinforcement of wheel running in BALB/c mice: role of motor activity and endogenous opioids

The authors investigated the effect of the opioid antagonist naloxone on wheel-running behavior in Balb/c mice. Naloxone delayed the acquisition of wheel-running behavior, but did not reduce the expression of this behavior once acquired. Delayed acquisition was not likely a result of reduced locomotor activity, as naloxone-treated mice did not exhibit reduced wheel running after the behavior was acquired, and they performed normally on the rotarod test. However, naloxone-blocked conditioned place preference for a novel compartment paired previously with wheel running, suggesting that naloxone may delay wheel-running acquisition by blocking the rewarding or reinforcing effects of the behavior. These results suggest that the endogenous opioid system mediates the initial reinforcing effects of wheel running that are important in acquisition of the behavior.     

Evaluation of Siddha Samadhi Yoga for anxiety and depression symptoms: a preliminary study

Siddha Samadhi Yoga is a program in which meditation is associated with pranayama (breathing exercises). 22 volunteers with anxiety complaints (M age = 42.8 yr., SD = 10.3) were assigned to two groups: 14 attended the yoga group, and 8 attended a waiting-list or control group. They were evaluated before the intervention and 1 month after it on the State-Trait Anxiety Inventory, the Beck Depression Inventory, Tension Feelings Self-evaluation Scales, and the Well-being Self-evaluation Scales. A significant reduction in scores on anxiety, depression, and tension was found in yoga group, as well as an increase in well-being in comparison with the control group.     

Effects of aging on the neural correlates of successful item and source memory encoding

To investigate the neural basis of age-related source memory (SM) deficits, young and older adults were scanned with fMRI while encoding faces, scenes, and face-scene pairs. Successful encoding activity was identified by comparing encoding activity for subsequently remembered versus forgotten items or pairs. Age deficits in successful encoding activity in hippocampal and prefrontal regions were more pronounced for SM (pairs) as compared with item memory (faces and scenes). Age-related reductions were also found in regions specialized in processing faces (fusiform face area) and scenes (parahippocampal place area), but these reductions were similar for item and SM. Functional connectivity between the hippocampus and the rest of the brain was also affected by aging; whereas connections with posterior cortices were weaker in older adults, connections with anterior cortices, including prefrontal regions, were stronger in older adults. Taken together, the results provide a link between SM deficits in older adults and reduced recruitment of hippocampal and prefrontal regions during encoding. The functional connectivity findings are consistent with a posterior-anterior shift with aging previously reported in several cognitive domains and linked to functional compensation.     

Psychache and suicide: a preliminary investigation

Shneidman's Psychological Pain Assessment Scale (PPAS; 1999) was administered to 88 psychiatric patients. Both current and worst-ever psychache were significantly higher in those patients judged by a psychiatrist, on the basis of a structured clinical interview, to be at risk of suicide. However, current and worstever psychache were not associated with having attempted suicide in the past. Thus, for the present sample of psychiatric patients, the PPAS appears to be more sensitive to current suicidality than to past suicidality. Further, there are validity issues with the PPAS, with the need for multi-item measures and probably a multifactor measure.     

A Comparison of the Factorial Structure of DSM-IV Criteria for Generalized Anxiety Disorder Between Younger and Older Adults

The controversy concerning the validity and reliability of generalized anxiety disorder (GAD) appears to be particularly relevant in the elderly, since physical symptoms associated with GAD can readily be considered as the consequences of normal aging. This study aims to analyze the structure invariance of a questionnaire assessing the DSM-IV diagnostic criteria across samples of older adults and college students. Ninety-seven adults aged 65 or over and 130 college students completed the Worry and Anxiety Questionnaire (WAQ). The results revealed that factorial invariance could be assumed and, in addition, that scores for severity of GAD symptoms were higher in younger subjects than in older ones. The results support the applicability of DSM-IV criteria for GAD in elderly people, as the factorial structure of the WAQ was the same for this age group as for younger adults. A higher degree of GAD severity was found in the younger sample.

Religions in Europe

The breakdown of European society is changing rapidly, particularly in the field of religion. Culture is of vital importance to the presence of religion in all nations. Religions also have exerted a certain degree of political power, thus influencing the economy and other related spheres of life.The different religions in Europe exhibit a variety of attitudes towards religious pluralism. The religious differences between Western and Eastern Europe depend mainly on issues of national identity related to religious adherence.This essay provides an overview of religion and politics, or Church and state, in Europe. It will conclude with some reflections about possible future developments within religious traditions in Europe. New religious communities and religious organisations are reaching different parts of Europe, sometimes very far from their place of origin. Christianity (Catholicism, Orthodoxy, and Protestantism) is the most widespread religion in contemporary Europe. Catholic religion is well diffused in Europe, but there are substantial differences in belief, behaviour and practice within different Catholic communities. There are various branches of Orthodoxy in Europe, such as the distinct autocephalous churches. In general Orthodox religion is closely aligned with national culture. Islam is also present in Western countries, and its impact is evident.     

Effects of Aging on Functional Connectivity of the Amygdala for Subsequent Memory of Negative Pictures: A Network Analysis of Functional Magnetic Resonance Imaging Data

ABSTRACT— Aging is associated with preserved enhancement of emotional memory, as well as with age-related reductions in memory for negative stimuli, but the neural networks underlying such alterations are not clear. We used a subsequent-memory paradigm to identify brain activity predicting enhanced emotional memory in young and older adults. Activity in the amygdala predicted enhanced emotional memory, with subsequent-memory activity greater for negative stimuli than for neutral stimuli, across age groups, a finding consistent with an overall enhancement of emotional memory. However, older adults recruited greater activity in anterior regions and less activity in posterior regions in general for negative stimuli that were subsequently remembered. Functional connectivity of the amygdala with the rest of the brain was consistent with age-related reductions in memory for negative stimuli: Older adults showed decreased functional connectivity between the amygdala and the hippocampus, but increased functional connectivity between the amygdala and dorsolateral prefrontal cortices. These findings suggest that age-related differences in the enhancement of emotional memory might reflect decreased connectivity between the amygdala and typical subsequent-memory regions, as well as the engagement of regulatory processes that inhibit emotional responses.     

Enhanced inhibitory avoidance learning prevents the long-term memory-impairing effects of cycloheximide,a protein synthesis inhibitor

Interference with activity of numerous cerebral structures produces memory deficiencies; in many instances, however, when animals are over-trained such interference becomes innocuous. Systemic administration of protein synthesis inhibitors impairs long-term retention; this effect has been interpreted to mean that protein synthesis is required for memory consolidation, though little is known about the effect of protein synthesis inhibitors on memory of enhanced learning in the rat. To further analyze the protective effect of enhanced learning against amnesic treatments, groups of Wistar rats were trained in a one-trial step-through inhibitory avoidance task, using different intensities of foot-shock during training. Cycloheximide (CXM; 2.8 mg/kg), an inhibitor of protein synthesis, was injected either 30 min before training or immediately after training. Twenty-four hours after training retention latencies were recorded. Our data showed that both pre- and post-training administration of CXM produced amnesia in those groups that had been trained with relatively low foot-shock intensities, but no impairment in retention was observed when relatively high intensities of foot-shock were administered. These and similar results lead us to conclude that protein synthesis inhibitors may interfere with memory consolidation, but their effect disappears when animals are submitted to an enhanced learning experience, calling into question the idea that protein synthesis is required for memory consolidation.     

Stroop effects on redemption and semantic effects on confession: simultaneous automatic activation of embedded and carrier words

The present study was aimed at assessing whether focusing attention on a task-relevant part of a word prevents processing of its meaning. Participants performed a color-naming task on a prime word followed by lexical decision on a probe. Primes were words, which could contain an embedded color word (e.g., “redemption”) written in an incongruent color. Probes were either semantically related (e.g., “confession”) or unrelated (e.g., “production”) to the prime word. A Stroop effect emerged for color words appearing either in the initial or in the final position of the carrier word. A priming effect also emerged, with faster responses to probes semantically related to the prime. These results are evidence that focusing attention on part of a prime (i.e., the embedded color word) does not prevent the semantic processing of the entire word.