Effects of Comt Genotype on Behavioral Symptomatology in the 22q11.2 Deletion Syndrome

The 22q11.2 Deletion Syndrome (DiGeorge/velocardiofacial syndrome) is associated with elevated rates of psychosis, and is also characterized by severe attentional difficulties and executive dysfunction. Behavioral manifestations of this syndrome could result from haploinsufficiency of the catechol-O-methyltransferase (COMT) gene, located within the 22q11 region. The goal of the present study was to examine COMT genotype in relation to behavioral symptomatology in this syndrome. Val^158/108Met was genotyped in 38 patients (16 Met/-, 22 Val/-) with confirmed 22q11.2 deletions who had received the Child Behavior Checklist (CBCL) as part of a comprehensive evaluation. Results indicated that the Val genotype was associated with significantly greater internalizing and externalizing behavioral symptomatology in children with 22q11.2 deletions. Val allele status was associated with a greater-than-four-fold increase in risk for clinically significant behavior problems in children with this syndrome. These data are consistent with previous findings of increased psychopathology associated with the Val genotype in normal individuals and suggest that a functional genetic polymorphism in the 22q11 region may influence behavior in individuals with COMT haploinsufficiency.     

Adverse Childhood Experiences and Diabetes in Adulthood: Support for a Collaborative Approach to Primary Care

Prior studies have demonstrated an association between retrospective reports of experiencing trauma in childhood and the current incidence of type 2 diabetes in adulthood. Much less is known about this association among low-income minority patients in primary care settings. We replicated the adverse childhood experiences (ACEs) Centers for disease control and prevention (CDC) study with a low-income minority sample of primary care patients (N = 801) at a community-based healthcare center. We conducted a cross-sectional retrospective quantitative survey study to examine the association between participants’ reports of past childhood trauma and their current health care outcomes. Data were analyzed using binary logistic regression to evaluate the hypothesis that low income minority patients who reported more childhood trauma (abuse, neglect, household dysfunction, cumulative adverse childhood experiences [ACEs]) would more likely be diagnosed with type 2 diabetes. Results suggest that the number of ACEs in our sample were considerably higher than the original CDC ACEs study, as almost 50 % of patients surveyed at our clinic reported 4 or more ACEs, confirming that trauma is central in our urban primary care setting. The results of the cumulative ACEs score was in the expected direction and was significant, suggesting that participants who cumulatively reported experiencing more childhood trauma were more likely to be diagnosed with type 2 diabetes in adulthood. These findings have implications for family therapists, primary care providers, researchers, and policy makers to develop more collaborative approaches to primary care that better target the negative sequelae of ACEs.     

Handedness in a virtual haptic environment: Assessments from kinematic behavior and modeling

This study evaluated hand asymmetries in performance of a dexterous, controlled task under haptic feedback. Participants punctured a virtual membrane with a pushing or pulling movement, using the left or right hand. For pulling movements, the dominant (right) hand exhibited faster average stopping latency and shorter skidding distance. When the kinematic data were fit to a three-phase model previously applied to this task (Klatzky et al., 2013), the right hand exhibited faster force decay attributable to biomechanical factors. Analyses of the aggregated performance measures and model parameters showed that the left and right hands are associated with two different distributions, supporting handedness effects. Furthermore, while the majority of participants expressed right-hand dominance, which was consistent with their self-reported hand preferences, others showed partial or no dominance. This approach could potentially be extended to quantify and differentiate individuals with difficulties in manual behavior due to abnormal motor control (e.g., dyspraxia), progressive deterioration (e.g., Parkinson's syndrome) or improvement (neural regrowth after transplant).     

Attentional control in the attentional blink is modulated by odor

Increasing evidence suggests that `aromas have distinctive effects on the allocation of attention in space: Arousing olfactory fragrances (e.g., peppermint) are supposed to induce a more focused state, and calming olfactory fragrances (e.g., lavender) a broader attentional state. Here, we investigate whether odors have similar effects on the allocation of attention in time. Participants performed the attentional blink (AB) task, known to produce a deficit in reporting the second of two target stimuli presented in close succession in a rapid sequence of distractors, while being exposed to either a peppermint or a lavender aroma. In two experiments using a between-subjects and a within-subjects design, respectively, we show that the two odors have specific effects on attentional control: As compared with the calming lavender aroma, the arousing peppermint condition yielded a larger AB. Our results demonstrate that attentional control is systematically modulated by factors that induce a more or a less distributed state of mind.     

Increasing ethnic minority participation in substance abuse clinical trials: lessons learned in the National Institute on Drug Abuse's Clinical Trials Network

Underrepresentation in clinical trials limits the extent to which ethnic minorities benefit from advances in substance abuse treatment. The objective of this article is to share the knowledge gained within the Clinical Trials Network (CTN) of the National Institute on Drug Abuse and other research on recruiting and retaining ethnic minorities into substance abuse clinical trials. The article includes a discussion of two broad areas for improving inclusion-community involvement and cultural adaptation. CTN case studies are included to illustrate three promising strategies for improving ethnic minority inclusion: respondent-driven sampling, community-based participatory research, and the cultural adaptation of the recruitment and retention procedures. The article concludes with two sections describing a number of methodological concerns in the current research base and our proposed research agenda for improving ethnic minority inclusion that builds on the CTN experience.     

Generalized others and imaginary audiences: A neo-Meadian approach to adolescent egocentrism

Piaget’s conception of adolescent egocentrism, as interpreted and extended by Elkind (1967) is discussed, and research that has related Elkind’s egocentric ideations of personal fable and imaginary audience to age and intellectual development is considered. Alternative theories of adolescent egocentrism and its decentration are examined, and a neo-Meadian framework is discussed that understands the imaginary audience ideation of adolescents as a possibly functional, highly variable response to the complex task of coordinating individual and social perspectives as part of the adolescent’s search for identity.     

Who is crossing where? Infants' discrimination of figures and grounds in events

To learn relational terms such as verbs and prepositions, children must first dissect and process dynamic event components. This paper investigates the way in which 8- to 14-month-old English-reared infants notice the event components, figure (i.e., the moving entity) and ground (i.e., stationary setting), in both dynamic (Experiment 1) and static representations of events (Experiment 2) for categorical ground distinctions expressed in Japanese, but not in English. We then compare both 14- and 19-month-old English- and Japanese-reared infants’ processing of grounds to understand how language learning interacts with the conceptualization of these constructs (Experiment 3). Results suggest that (1) infants distinguish between figures and grounds in events; (2) they do so differently for static vs. dynamic displays; (3) early in the second year, children from diverse language environments form nonnative – perhaps universal – event categories; and (4) these event categories shift over time as children have more exposure to their native tongue.     

in‐house career coaching: an international partnership

This article describes a project in the United Arab Emirates (UAE) to develop an inhouse career coaching program to support and develop young employees recruited on an affirmative action initiative. The project involved the international partnership of a financial services organization in the UAE and a training provider in Canada to train human resources and learning and development professionals in basic career coaching skills. Initial evaluation showed promising potential for in‐house career coaching as a tool for employee engagement and retention and for the usefulness of such partnerships between career professionals and organizations.     

An Unmatched Case‐Control Study of Nearly Lethal Suicide Attempts in Houston,Texas: Research Methods and Measurements

T his article details the research methods and measurements used in conducting a population‐based, case‐control study of nearly lethal suicide attempts among persons aged 13–34 years, residing in Houston, Texas. From November 1992 to July 1995, we interviewed 153 case subjects presenting at one of three participating hospital emergency departments and used random digit dialing to identify 513 control subjects residing in the same catchment area in which cases were enlisted. Unlike most research in this area, this study was designed to extend our understanding of suicidal behavior and prevention activities beyond identification and treatment of depression and other mental illnesses. We discuss the overall strengths and weaknesses of our study design and conclude that this methodology is well suited for studying rare outcomes such as nearly lethal suicide.     

Whining as mother‐directed speech

Although little studied, whining is a vocal pattern that is both familiar and irritating to parents of preschool‐ and early school‐age children. The current study employed multidimensional scaling to identify the crucial acoustic characteristics of whining speech by analysing participants' perceptions of its similarity to other types of speech (question, neutral speech, angry statement, demand, and boasting). We discovered not only that participants find whining speech more annoying than other forms of speech, but that it shares the salient acoustic characteristics found in motherese, namely increased pitch, slowed production, and exaggerated pitch contours. We think that this relationship is not random but may reflect the fact that the two forms of vocalization are the result of a similar accommodation to a universal human auditory sensitivity to the prosody of both forms of speech. Copyright © 2005 John Wiley & Sons, Ltd.