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The crane's foot: The rise of the pedigree in human genetics 总被引:1,自引:1,他引:0
Robert G. Resta 《Journal of genetic counseling》1993,2(4):235-260
The standard pedigree used by geneticists is intimately connected to the history of genetics. Pedigrees drawn today are based on standards established in the early decades of the twentieth century. Those standards were established by geneticists who pursued an active interest in eugenics. The slightly different standards followed in America vs. England to some extent followed the stronger support of Mendelism by the Americans, as well as the individual preferences of the leading human geneticists in those countries. 相似文献
257.
Carol Z. Garrison Ph.D. Cheryl L. Addy Ph.D. Robert E. McKeown Ph.D. Steven P. Cuffe M.D. Kirby L. Jackson A.B. Jennifer L. Waller Ph.D. 《Journal of child and family studies》1993,2(4):339-352
To determine the frequency and correlates of nonsuicidal physically self-damaging acts in 12–14 year olds, a two stage epidemiologic survey with a self-administered questionnaire (N=3283) followed by a psychiatric interview of a subsample of the adolescents and their parents (N=444) was used. Prevalence estimates of interview validated nonsuicidal physically self-damaging acts were 2.46% in males and 2.79% in females. Significant relationships were found between nonsuicidal physically self-damaging acts and suicidal ideation, major depression and undesirable life events. Data suggest that physically self-damaging acts occur at substantial rates during early adolescence. The strong correlation between nonsuicidal self-destructive acts and both suicidal ideation and major depression clarifies prior conflicting reports in the literature and suggests that a history of self-damaging acts should be taken into consideration when evaluating for possible depression and suicide risk. 相似文献
258.
Robert Rosen 《Theoretical medicine and bioethics》1993,14(2):89-100
Physics says that it cannot deal with the mind-brain problem, because it does not deal in subjectivities, and mind is subjective. However, biologists (among others) still claim to seek a material basis for subjective mental processes, which would thereby render them objective. Something is clearly wrong here. I claim that what is wrong is the adoption of too narrow a view of what constitutes ‘objectivity’, especially in identifying it with what a ‘machine’ can do. I approach the problem in the light of two cognate circumstances: (a) the ‘measurement problem’ in quantum physics, and (b) the objectivity of standard mathematics, even though most of it is beyond the reach of ‘machines’. I argue that the only resolution to such problems is in the recognition that closed loops of causation are ‘objective’; i.e. legitimate objects of scientific scrutiny. These are explicitly forbidden in any machine or mechanism. A material system which contains such loops is called ‘complex’. Such complex systems thus must possess nonsimulable models; i.e. models which contain impredicativities or ‘self-references’ which cannot be removed, or faithfully mapped into a single coherent syntactic time-frame. I consider a few of the consequences of the above, in the context of thus redrawing the boundary between subject and object. 相似文献
259.
The LogicR4 is obtained by adding the axiom (A vB(AvB) to the modal relevant logicNR. We produce a model theory for this logic and show completeness. We also show that there is a natural embedding of a Kripke model forS4 in eachR4 model structure.We are indebted to several people for discussions relating to the topic of this paper, in particular, Kit Fine, John Slaney, J. M. Dunn, Jacques Riche, M. A. McRobbie, and Jill LeBlanc. We would also like to thank the Automated Reasoning Project for material assistance. Mares would like to thank The Social Sciences and Humanities Research Council of Canada for fellowships 456-89-0128 and 457-90-0081, which supported him while writing this paper. 相似文献
260.
Genetic and Environmental Effects on Openness to Experience, Agreeableness, and Conscientiousness: An Adoption/Twin Study 总被引:4,自引:0,他引:4
C. S. Bergeman Heather M. Chlpuer Robert Plomin Nancy L. Pedersen G. E. McClearn John R. Nesselroade Paul T. Costa Jr. Robert R. McCrae 《Journal of personality》1993,61(2):159-179
ABSTRACT Previous research has indicated that extraversion and neuroticism are substantially affected both by genotype and environment. This study assesses genetic and environmental influences on the other three components of the five-factor model of personality: Openness to Experience, Agreeableness, and Conscientiousness. An abbreviated version of the NEO Personality Inventory (NEO-PI) was administered to 82 pairs of identical twins and 171 pairs of fraternal twins reared apart and 132 pairs of identical twins and 167 pairs of fraternal twins reared together. Estimates of genetic and environmental effects for Openness and Conscientiousness were similar to those found in other studies of personality: Genetic influence was substantial and there was little evidence of shared rearing environment. Results for Agreeableness were different: Genetic influence accounted for only 12% of the variance and shared rearing environment accounted for 21% of the variance. Few significant gender or age differences for genetic and environmental parameters were found in model-fitting analyses. 相似文献