Female CGG knock-in mice modeling the fragile X premutation are impaired on a skilled forelimb reaching task

The fragile X premutation is a tandem CGG trinucleotide repeat expansion in the fragile X mental retardation 1 (FMR1) gene between 55 and 200 repeats in length. A CGG knock-in (CGG KI) mouse has been developed that models the neuropathology and cognitive deficits reported in fragile X premutation carriers. Previous studies have demonstrated that CGG KI mice have spatiotemporal information processing deficits and impaired visuomotor function that worsen with increasing CGG repeat length. Since skilled forelimb reaching requires integration of information from the visual and motor systems, skilled reaching performance could identify potential visuomotor dysfunction in CGG KI mice. To characterize motor deficits associated with the fragile X premutation, 6 month old female CGG KI mice heterozygous for trinucleotide repeats ranging from 70-200 CGG in length were tested for their ability to learn a skilled forelimb reaching task. The results demonstrate that female CGG KI mice show deficits for learning a skilled forelimb reaching task compared to wildtype littermates, and that these deficits worsen with increasing CGG repeat lengths.     

Dissociating object-based and space-based affordances

In what we term the orientation effect, faster spatial responses are made to the corresponding task irrelevant orientation of an object. We ask how this effect relates to object affordances, how attention may be involved, and how the effect relates to the better understood Simon effect. Two separate stimulus-response compatibility effects (an orientation effect and a Simon effect) were observed when spatial responses were made to photographs of objects whose orientation and location had been simultaneously manipulated. When attentional demands were high these separate effects were found using hand responses and foot responses, suggesting an abstract rather than specific coding of object affordances. However, when attentional demands were low only the Simon effect was observed, suggesting that, in order to obtain the orientation effect, objects must be represented at the level of an object.     

A 32-Year Longitudinal Study of Child and Adolescent Pathways to Well-Being in Adulthood

The purpose of the study was to investigate the relative importance of child and adolescent social and academic pathways to well-being in adulthood (32-years) indicated by a sense of meaning, social engagement, positive coping and prosocial values. Data were drawn from a 15 wave (32-year) longitudinal study of the health and development of around 1000 New Zealanders (Dunedin Multidisciplinary Health and Development Study, New Zealand). Moderate continuity in social connectedness (0.38) and high continuity in academic ability (0.90) was observed across childhood and adolescence. Adolescent social connectedness was a better predictor of adult well-being than academic achievement (0.62 vs. 0.12). There was evidence of an indirect pathway from adolescent academic achievement to adult well-being through social connectedness (0.29). Indicators of well-being in adulthood appear to be better explained by social connection rather than academic competencies pathways. Implications for promoting longer term well-being during the school years are discussed.     

Detection and Validation of Unscalable Item Score Patterns Using Item Response Theory: An Illustration with Harter's Self-Perception Profile for Children

To test the hypothesis that age of first separation from a home environment is a factor in the emotional health of institutionalized boys, Rorschach protocols of 82 residents of Saint Francis Vocational School, a facility for deprived nondelinquent nonretarded youth aged 10 to 18, were examined. Seven Rorschach variables were used as dependent variables of emotional status. It was found that boys who had first been institutionalized before age 10 gave more color-dominant and pure color responses (p .005), and more responses with pathological overtones (p < .005), than did youth first placed at ages 10 to 13 or ages 14 to 17. Fixation was proposed as the basis for the group differences.     

Volume completion in 4.5-month-old infants

In this study, we examined 4.5-month-old infants' visual completion of self-occluding three-dimensional objects. A previous study on this topic reported that 6-month-old, but not 4-month-old infants extrapolate a convex, symmetric prism from a limited view of its surfaces (Soska & Johnson, 2008). As of yet, studies on the development of amodal completion of three-dimensional, self-occluding objects are scarce. Given 4-month-old infants' abilities to derive three-dimensional shape from a variety of visual cues, three-dimensional amodal completion may well depend on the perceptual strength of three-dimensionality in the stimulus displays. The first experiments (1A and 1B) tested this hypothesis by means of a habituation paradigm and showed that 4.5-month-old infants are indeed able to amodally complete the back of a self-occluding object when sufficient three-dimensional cues are available. Further support for volume completion in 4.5-month-old infants was found in a second experiment, again using a habituation paradigm, that measured perceived connectedness between two visually separated, self-occluding, three-dimensional objects.     

Size matters: Attracting new immigrants to Canadian cities

Montreal, Toronto, and Vancouver have attracted most new immigrants to Canada. Small and medium-sized cities in Canada are keen to share the wealth that new immigrants represent, and federal and provincial governments support a more even distribution of settlement. As a result, the idea of attracting new immigrants to smaller locations is a pressing policy issue. This research weighs the characteristics of place that new immigrants consider on arrival. It uses findings from the Longitudinal Survey of Immigrants to Canada (Statistics Canada, 2003) to construct an index that ranks five medium-sized cities in British Columbia in terms of their potential attractiveness to new immigrants. The index created proves robust and reliable from a statistical viewpoint. The study confirms that immigrants are attracted to cities where friends and family or other immigrants live. Moreover, the increase in attractiveness of a city is primarily related to its size. The index is an indicator of the role that population and the extant number of immigrants in situ plays in determining the appeal of smaller cities. From a policy perspective, if governments wish to “spread the wealth” associated with immigration and an expanded labour force, a proactive policy stance that enumerates and communicates the appeal of less prominent communities is vital. This is an important finding, and we offer policy options that account for the relationship of population size to immigrant retention.     

Introducing research methods and reflexivity into family therapy training

Research training does not always sit easily with family therapy trainees due to the perceived difficulty of the terrain and the mismatch between the primacy given to research and their developing expertise in the clinical work. Despite these tensions, research forms a core component to advanced training and is a requisite module for students completing an M.Sc. Following the provision of suboptimal teaching in research methods for M.Sc. candidates, a substantial redesign of the course was undertaken, taking into account the context of students' learning. This paper reports on the contextual influences on this new approach, and outlines the key pedagogical strategies that support student learning within the formal teaching sessions and beyond. We present a summary of the outcomes so far.     

Regulating cognitive control through approach-avoidance motor actions

In two studies, the regulatory function of approach-avoidance cues in activating cognitive control processes was investigated. It was hypothesized that avoidance motor actions, relative to approach motor actions, increase the recruitment of cognitive resources, resulting in better performance on tasks that draw on these capacities. In Study 1, error rates on a verbal response mode version of the Stroop task were analyzed. On inconsistent Stroop trials, participants in the avoidance condition made significantly fewer errors than those in the approach condition. In Study 2, performance differences on a task switching paradigm were investigated. Crucially, approach and avoidance motor actions were manipulated within-subjects by alternating between approach and avoidance motor actions on 4 blocks of trials. Temporal switching costs were significantly lower while performing an avoidance, compared to an approach motor action. These results support our hypothesis that avoidance cues, relative to approach cues, lead to improved performance on cognitive control tasks.     

When approach motivation and behavioral inhibition collide: Behavior regulation through stimulus devaluation

In the present article a theory is outlined that explains why and when behavioral inhibition alters stimulus evaluations. In addition, some initial evidence is presented that supports the theory. Specifically, results of three experiments show that refraining from responding to stimuli results in devaluation of these stimuli, but only when these stimuli are positive. These findings suggest automatic behavior-regulation, in terms of devaluation of positive stimuli, in situations in which environmental cues triggering approach (because of the positive valence of the stimulus) run counter to situational demands (cues that elicit behavioral inhibition). Relations of the present research to self-perception, cognitive dissonance, and psychological reactance are discussed.