Monitoring in clinical trials: benefit or bias?

Monitoring ongoing clinical trials for early signs of effectiveness is an option for improving cost-effectiveness of trials that is becoming increasingly common. Alongside the obvious advantages made possible by monitoring, however, there are some downsides. In particular, there is growing concern in the medical community that trials stopped early for benefit tend to overestimate treatment effect. In this paper, I examine this problem from the point of view of statistical methodology, starting from the observation that the overestimation is caused by the statistical method adopted. Consequently, I argue that some modifications can and should be made to the present statistical framework in order not to miss the advantages the possibility of monitoring can grant.     

Early Learning Experience and Adolescent Anxiety: A Cross-Cultural Comparison Between Japan and England

The main aim of this study was to compare the frequency of anxiety symptoms among adolescents in Japan and England, and to examine the association between early learning experiences and anxiety symptoms. A total of 299 adolescents (147 from England and 152 from Japan), aged 12 to 17 years were investigated. Results showed that adolescents in England reported significantly higher levels of anxiety symptoms than adolescents in Japan. For early learning experiences, no significant differences emerged between the two countries for parent punishment and reinforcement of anxious behavior. However, for non-anxiety physical symptoms (i.e. cold), adolescents in England scored significantly higher in parent punishment and the Japanese sample scored higher in parent reinforcement. Parent verbal transmission about the danger of anxiety and cold symptoms was more common in Japan than in England. The impact of learning experience on adolescent’s anxiety seemed to differ across cultures, which underscore the importance of cultural factors on adolescent’s anxiety.     

Training social cognition: from imitation to Theory of Mind

Evidence for successful socio-cognitive training in typical adults is rare. This study attempted to improve Theory of Mind (ToM) and visual perspective taking in healthy adults by training participants to either imitate or to inhibit imitation. Twenty-four hours after training, all participants completed tests of ToM and visual perspective taking. The group trained to inhibit their tendency to imitate showed improved performance on the visual perspective-taking test, but not the ToM test. Neither imitation training, nor general inhibition training, had this effect. These results support a novel theory of social cognition suggesting that the same self-other discrimination process underlies imitation inhibition and perspective taking. Imitation, perspective taking and ToM are all pro-social processes--ways in which we reach out to others. Therefore, it is striking that perspective taking can be enhanced by suppressing imitation; to understand another, sometimes we need, not to get closer, but to pull away.     

What's social about social learning?

Research on social learning in animals has revealed a rich variety of cases where animals--from caddis fly larvae to chimpanzees--acquire biologically important information by observing the actions of others. A great deal is known about the adaptive functions of social learning, but very little about the cognitive mechanisms that make it possible. Even in the case of imitation, a type of social learning studied in both comparative psychology and cognitive science, there has been minimal contact between the two disciplines. Social learning has been isolated from cognitive science by two longstanding assumptions: that it depends on a set of special-purpose modules--cognitive adaptations for social living; and that these learning mechanisms are largely distinct from the processes mediating human social cognition. Recent research challenges these assumptions by showing that social learning covaries with asocial learning; occurs in solitary animals; and exhibits the same features in diverse species, including humans. Drawing on this evidence, I argue that social and asocial learning depend on the same basic learning mechanisms; these are adapted for the detection of predictive relationships in all natural domains; and they are associative mechanisms--processes that encode information for long-term storage by forging excitatory and inhibitory links between event representations. Thus, human and nonhuman social learning are continuous, and social learning is adaptively specialized--it becomes distinctively "social"--only when input mechanisms (perceptual, attentional, and motivational processes) are phylogenetically or ontogenetically tuned to other agents.     

The roles of categorical and coordinate spatial relations in recognizing buildings

Categorical spatial information is considered more useful for recognizing objects, and coordinate spatial information for guiding actions??for example, during navigation or grasping. In contrast with this assumption, we hypothesized that buildings, unlike other categories of objects, require both categorical and coordinate spatial information in order to be recognized. This hypothesis arose from evidence that right-brain-damaged patients have deficits in both coordinate judgments and recognition of buildings and from the fact that buildings are very useful for guiding navigation in urban environments. To test this hypothesis, we assessed 210 healthy college students while they performed four different tasks that required categorical and coordinate judgments and the recognition of common objects and buildings. Our results showed that both categorical and coordinate spatial representations are necessary to recognize a building, whereas only categorical representations are necessary to recognize an object. We discuss our data in view of a recent neural framework for visuospatial processing, suggesting that recognizing buildings may specifically activate the parieto-medial-temporal pathway.     

Psychosocial Factors Predicting SARS-Preventive Behaviors in Four Major SARS-Affected Regions

This multinational study examined intended and actual adoption of SARS-preventive behaviors in major SARS-affected regions: Guangdong (China), Hong Kong, Singapore, and Toronto (Canada). The theory of reasoned action (TRA) and the theory of planned behavior (TPB) were adopted as theoretical frameworks. A measure was constructed to assess attitude, subjective norm, perceived behavioral control (PBC), knowledge of SARS, and SARS-preventive behaviors. Seventy-five working adults were recruited from each region. They completed the new measure in an initial study, and reported their actual behaviors 2 weeks later. Results provided cross-cultural generalizability of the TRA by showing that attitude and subject norm predicted SARS-preventive behaviors for all the groups. PBC was a statistically significant predictor for all participants except those from Guangdong, indicating that the TPB is applicable only to people from Hong Kong, Singapore, and Toronto. Knowledge of SARS also was found to be an independent predictor.     

EVALUATION OF RAPE VICTIM BY MEN AND WOMEN WITH HIGH AND LOW BELIEF IN A JUST WORLD

Men with high belief in a just world evaluated a videotaped rape victim more negatively than did men with low belief in a just world. Women with high belief in a just world were less negative toward the rape victim than women with low belief in a just world. Participants with low belief in a just world recommended significantly longer prison sentences for the rapist. Evaluations of the rapist and rape victim were not influenced by information about the outcome of the case (the rapist was never caught, the rapist was caught and sentenced to either 1 or 15 years in prison). Implications for just-world beliefs of jurors in rape trials were discussed.     

Gender-Role Differences in Susceptibility to the Influence of Support Availability on Depression

Previous gender-role research on depression has revealed a consistent inverse relationship between masculinity and depression, but a non-significant relationship between femininity and depression. In light of the stronger affiliative needs for feminine individuals, received social support was speculated to moderate the relationship between femininity and depression in the present research. In a longitudinal study of a sample of Hong Kong college students, the relationships among gender-role orientation, received social support, and depression were examined. Consistent with previous findings, masculinity and androgyny were inversely related to depression. Moreover, the present study supplemented previous research by revealing that femininity was related to depression through its interaction with received social support. When the amount of received social support was increased, femininity was associated with a reduction in depression level over time. In contrast, when the amount of received social support was decreased, depression tended to increase with femininity over time. The findings are discussed in terms of their implications for the gender-role literature.     

Role of Perceived Social Support on Depression in Chinese Adolescents: A Prospective Study Examining the Buffering Model

In response to the dearth of attempts to examine functions of perceived social support on depression in Chinese adolescents, a prospective study was conducted to examine the relationship among stressful life events, perceived social support, and depression. The present results provided support for the buffering model, indicating that the function of perceived social support in mitigating subsequent depression was prominent only under high stress levels. These results were discussed in terms of the socialized role of Chinese adolescents, as well as the function of esteem enhancement of perceived social support in alleviating depression. Reciprocal relationships between initial depression levels and subsequent levels of social support were also discussed. Possible counseling and prevention programs for Chinese adolescents are proposed.