Modeling recall memory for emotional objects in Alzheimer's disease

ABSTRACT

Objective: To examine whether emotional memory (EM) of objects with self-reference in Alzheimer's disease (AD) can be modeled with binomial logistic regression in a free recall and an object recognition test to predict EM enhancement.?Method: Twenty patients with AD and twenty healthy controls were studied. Six objects (three presented as gifts) were shown to each participant. Ten minutes later, a free recall and a recognition test were applied. The recognition test had target–objects mixed with six similar distracter objects. Participants were asked to name any object in the recall test and identify each object in the recognition test as known or unknown.?Results: The total of gift objects recalled in AD patients (41.6%) was larger than neutral objects (13.3%) and a significant EM recall effect for gifts was found (Wilcoxon: p < .003). EM was not found for recognition in AD patients due to a ceiling effect. Healthy older adults scored overall higher in recall and recognition but showed no EM enhancement due to a ceiling effect. A logistic regression showed that likelihood of emotional recall memory can be modeled as a function of MMSE score (p < .014) and object status (p < .0001) as gift or non-gift.?Conclusion: Recall memory was enhanced in AD patients for emotional objects indicating that EM in mild to moderate AD although impaired can be provoked with strong emotional load. The logistic regression model suggests that EM declines with the progression of AD rather than disrupts and may be a useful tool for evaluating magnitude of emotional load.     

Connecting Experience and Economy—Aspects of Disguised Positioning

The focus of this article is the use of experience made within the literature of the “new” economical discipline of experience economy. By combining a methodological individualism with a causal and dehumanising picture of the process of experience, this discipline conceives economic interactions as acts of autonomy. These acts, it is claimed, are part of economical instrumental reason restructuring itself by using experiences as tools in convincing consumers that they are free to pursue their respective paths of lives. Described through the use of positioning theory, however, this turns out to be a result of an effort of equipping consumers with a new economic norm of forced positioning disguised as deliberate self-positioning.     

Perception of lightness and illumination in a world of one reflectance

Observers looked into a miniature room in which everything was painted matte white, or--in another room--matte black. They made both reflectance and illumination judgments for eight test spots. The test spots (which varied in luminance) were perceived as approximately equal in reflectance--not different, as conventional contrast theories would seem to require. The illumination matches made to the same points, however, closely paralleled the pattern of actual illumination levels, and this result is discussed as evidence that edges are classified as changes in either reflectance or illumination. The white room was correctly perceived as white, and the black room was perceived as middle gray; similar results were obtained even when the luminances in the black room were higher (owing to higher illumination) than the corresponding luminances in the white room. An explanation in terms of differences in gradient patterns is presented and supported with luminance profiles.     

Retrospective and Prospective Cognitions in Anxiety and Depression

A study is reported that examined memory for past experiences and anticipation of future experiences within panic disorder patients (N = 17), depressed patients (N = 16), and controls (N = 17). Anticipation and recall of positive and negative experiences were examined by administering an adapted verbal fluency paradigm. Participants were asked to generate future and past, positive and negative experiences in response to various time-frame cues. Anxiety was associated with generating more negative experiences but not fewer positive experiences; depression was associated with generating fewer positive experiences but not more negative experiences. The patterns for recall of past experiences and anticipation of future experiences were very similar.     

Fatigue and Quality of Life Following Radiotherapy for Breast Cancer: A Comparative Study

Clinical reports suggest that fatigue is a common and disruptive long-term side effect of radiotherapy; however, there has been little systematic attention given to this phenomenon. The primary aim of this study was to assess fatigue its impact on quality of life in women who had completed radiotherapy for breast cancer. A key feature of this study was the inclusion of a comparison group of women of similar age with no history of cancer. The results indicated that the fatigue experienced by women after radiotherapy for breast cancer was not significantly different in intensity, duration, or disruptiveness from fatigue experienced by healthy women. In addition, radiotherapy recipients reported a quality of life similar to that of the healthy women. For both groups of women greater fatigue was related to a poorer quality of life. These findings suggest that following radiotherapy for breast cancer, women can expect to experience fatigue which is not worse than what they might normally experience. This information may be a useful part of psychoeducational interventions designed for women scheduled to begin radiotherapy for breast cancer.     

Approximate entropy and point correlation dimension of heart rate variability in healthy subjects

The contribution of nonlinear dynamics to heart rate variability in healthy humans was examined using surrogate data analysis. Several measures of heart rate variability were used and compared. Heart rates were recorded for three hours and original data sets of 8192 R-R intervals created. For each original data set (n=34), three surrogate data sets were made by shuffling the order of the R-R intervals while retaining their linear correlations. The difference in heart rate variability between the original and surrogate data sets reflects the amount of nonlinear structure in the original data set. Heart rate variability was analyzed by two different nonlinear methods, point correlation dimension and approximate entropy. Nonlinearity, though under 10 percent, could be detected with both types of heart rate variability measures. More importantly, not only were the correlations between these measures and the standard deviation of the R-R intervals weak, the correlation among the nonlinear measures themselves was also weak (generally less than 0.6). This suggests that in addition to standard linear measures of heart rate variability, the use of multiple nonlinear measures of heart rate variability might be useful in monitoring heart rate dynamics.     

Does retrieval intentionality really matter? Similarities and differences between involuntary memories and directly and generatively retrieved voluntary memories

Theories of autobiographical memory distinguish between involuntary and voluntary retrieval as a consequence of conscious intention (i.e., wanting to remember). Another distinction can be made between direct and generative retrieval, which reflects the effort involved (i.e., trying to remember). However, it is unclear how intention and effort interacts. For example, involuntary memories and directly retrieved memories have been used interchangeably in the literature to refer to the same phenomenon of effortless, non‐strategic retrieval. More recent theoretical advances suggest that they are separate types of retrieval, one unintentional (involuntary), another intentional and effortless (direct voluntary retrieval), and a third intentional and effortful (generative voluntary retrieval). Whether this also entails differing phenomenological characteristics, such as vividness, rehearsal, or emotional valence, has not been previously investigated. In the current study, participants reported memories in an experimental paradigm designed to elicit voluntary and involuntary memories and rated them on a number of characteristics. If intention affects the retrieval process, then we should expect differences between the characteristics of involuntary and directly retrieved memories. The results imply that retrieval intention seems to differentiate how a memory appears in a person's mind. Furthermore, we argue that these differences in part could result from differences in encoding and consolidation.