Tower of London test: a comparison between conventional statistic approach and modelling based on artificial neural network in differentiating fronto-temporal dementia from Alzheimer's disease

The early differentiation of Alzheimer's disease (AD) from frontotemporal dementia (FTD) may be difficult. The Tower of London (ToL), thought to assess executive functions such as planning and visuo-spatial working memory, could help in this purpose. Twentytwo Dementia Centers consecutively recruited patients with early FTD or AD. ToL performances of these groups were analyzed using both the conventional statistical approaches and the Artificial Neural Networks (ANNs) modelling. Ninety-four non aphasic FTD and 160 AD patients were recruited. ToL Accuracy Score (AS) significantly (p < 0.05) differentiated FTD from AD patients. However, the discriminant validity of AS checked by ROC curve analysis, yielded no significant results in terms of sensitivity and specificity (AUC 0.63). The performances of the 12 Success Subscores (SS) together with age, gender and schooling years were entered into advanced ANNs developed by Semeion Institute. The best ANNs were selected and submitted to ROC curves. The non-linear model was able to discriminate FTD from AD with an average AUC for 7 independent trials of 0.82. The use of hidden information contained in the different items of ToL and the non linear processing of the data through ANNs allows a high discrimination between FTD and AD in individual patients.     

2010 Working Bibliography of Teaching and Learning Publications and Presentations related to the Work of the Wabash Center by Wabash Center Participants and Grant Recipients

This bibliography lists articles and books on teaching produced by workshop participants and grant recipients of the Wabash Center. It updates a similar list produced in 2007 and published in volume 10 number 3 of this journal.     

Doing Good, Feeling Good, and Having More: Resources Mediate the Health Benefits of Altruism Differently for Males and Females with Lumbar Spine Disorders

We evaluated whether resources mediate and/or moderate the relationship between altruism and health outcomes in adults with lumbar spine disorders. Hierarchical regression modeling on 243 persons with lumbar spine disorders evaluated gender differences and whether physical, emotional, and economic resources mediated or moderated the relationship between altruism (Schwartz Altruism) and health (Rand-36, PROMIS Pain Impact). Men and women had similar altruism subscale scores, but there were gender differences in the altruism-health relationships. Both men and women had better mental health with higher levels of Community Connection, after adjusting for Community Pressure, and this effect was mediated by emotional resources. Women evidenced better physical health and less pain impact when they endorsed higher levels of Community Connection and/or General Helping aspects of altruism. Physical and economic resources partially but did not fully mediate women??s altruism-physical health link. The altruism-pain impact link was not significant after adjusting for covariates. Men and women report similar levels of altruism but enjoy different benefits. Emotional resources explained the altruism-mental health link in both genders, but women experienced a physical health benefit of altruism that was not mediated by resources. Future research should test causal relationships.     

The juncture of law and morality in prohibitions against torture

Conclusion The right to be secure from torture, a right that encompasses moral as well as legal strictures against the practice, is supported by increasingly stringent human rights instruments. In this essay, I have discussed the principal instruments and their place in the anti-torture field considered broadly. The phenomenon of these international instruments foreshadows an ever-widening range of legal initiatives against torture, and is emblematic of the increasing importance attached to respect for human life and human dignity. The diversity of international treaties providing against torture such as, for example, The Convention on the Prevention and Punishment of the Crime of Genocide (1948), The Supplementary Convention on the Abolition of Slavery (1956), The International Convention on the Elimination of All Forms of Racial Discrimination (1965), and The International Convention on the Suppression and Punishment of the Crime of Apartheid (1973), indicates the interconnectedness of a wide range of human rights issues.The boundaries that have been drawn around the violation constituted by torture are clearer at present than are those bounding many other rights. Rights commonly categorized as of an economic nature - the right to food and to development, for example - are undergoing processes of definition and implementation. One challenge of this paper is to generate procedures presently attached to such specific human rights violations as torture to rights with less clear parameters. In this way, the growing effectiveness of procedures against torture can serve in the long term to strengthen the bases of international human rights law while in the short term helping to expand the armory of procedures for the protection of less clearly-defined, rights. International human rights law offers a practical tool towards eliminating torture from states' instruments for governing and provides a model for the development of procedures in other categories of rights, while bringing universally declared moral aspirations and legal authority into closer alignment.     

Family processes,resourcefulness, coping,and stress: A prospective study

A review of the family therapy literature indicates that few studies have investigated the complex relationship among family processes, coping, and stress in understanding how people manage stressful events and conditions. The purpose of the present study was to utilize a prospective research design to systemically explore the impact of family processes on an individual's ability to use effective coping responses when faced with a stressful situation. The results did indicate that individuals experienced greater strain at Time 1 (awaiting exam). However, no differences were found between family process variables and an individual's coping responses between Time 1 and Time 2 (awaiting results). Suggestions for further research on intergenerational family systems theory and implications for family therapy practice are provided.     

Client gender and sex-typed nonverbal behavior: Impact on impression formation

The influence of sex-typed nonverbal behavior of male and female clients on college students' perceptions was investigated. In a 2 × 2 × 2 factorial design, 156 male and female college students were exposed to a videotaped interview during which either a male or female client displayed either masculine or feminine sex-typed nonverbal behaviors. Subjects rated the perceived characteristics, prognosis for improvement, and problems of the client. Hypothesized main effects for client gender and sex-typed nonverbal behavior did not obtain. However, the hypothesized client gender by sex-typed nonverbal behavior interaction was found. This result was due primarily to a pervasive tendency to stigmatize the female clients displaying masculine sex-typed behaviors, in comparison to male clients displaying these same behaviors. Possible explanations and implications for these observed effects were discussed.     

Threat,Knowledge, and Support for a Collective Response to Urban Flooding1

The most realistic solution to recurring urban flooding in most American cities is some form of land use planning (zoning), i.e., an integrated, collective response to this type of threat to the community. Yet there is frequently little public support for such action. The present study surveyed persons living in and around a notorious urban floodplain to assess support for such land use planning as a function of (a) threat, i.e., the motivational effect of proximity to the floodplain, ownership of property at risk, personal flooding history, perceived likelihood of one's home being flooded in the next 5 years, and the presence of small children in the home; and (b) amount of knowledge about variables affecting flooding, i.e., the cognitive element. Although proximity was related strongly to expressions of concern, none of the measures of threat was related to support for land use planning. Knowledge of the variables involved, however, was positively related to support for a planning solution. The findings are discussed in terms of theoretical implications of the cognitive element in collective responses to environmental hazards.     

The selective impairment of phonological processing: A case study

A case study is reported of an aphasic patient with fluent speech and markedly superior comprehension of written vs. spoken words. Results of extensive testing supported the hypothesis that the patient suffers from a phonological processing deficit that affects performance in all tasks that require the generation of a phonological code. This selective deficit is interpreted as the underlying cause of diverse symptoms such as asyntactic comprehension of written sentences, the commission of spelling errors in writing, and the production of literal paraphasias and neologisms in spontaneous speech. Alternative possibilities for the classification of this patient are discussed.