Education and testing strategy for large-scale cystic fibrosis carrier screening

Population-based screening for cystic fibrosis carrier mutations presents a number of challenges for genetic counselors, owing primarily to the inability of current DNA testing technology to identify all possible mutations and the difficulty involved in conveying the concept of residual risk to those patients who test negative. To address these issues, we are conducting a pilot study, as part of a consortium established by the National Center for Human Genome Research, to explore the efficacy, acceptance, and psychosocial impact of various approaches to carrier screening in an ethnically diverse Southern California population. This article reports the patient instructional and screening strategies we developed in the initial phase of the project in order to optimize our chances of answering these questions and delivering this service on a large scale.     

Applications of a computer algebra system for teaching bivariate relationships in statistics courses

Maple, a computer algebra system, is used in undergraduate psychology courses to promote students’ conceptual learning of basic principles associated with bivariate relationships. Maple’s symbolic computation, graphic displays, and animation capabilities are used along with other classroom activities to study concepts related to (1) correlation coefficients, scatterplots, and regression lines, (2) factors that affect the magnitude of sample correlations, (3) inferential tests, and (4) prediction error. For each of the 15 Maple procedures, students select population correlation values and examine the effects of different values on computer-generated graphical representations of scatterplots, regression lines, and sample correlations. The procedures are described and examples of exercises to support their use are provided.     

Perceived ethicality of guided imagery in rape research

In our first study, undergraduate students (30 men, 30 women) evaluated the ethical acceptability of two previously published studies that used guided imagery in rape situations. In one, women imagined themselves as rape victims; in the other, men imagined themselves as rapists. Most students rated the research acceptable, but there was a significant interaction (p less than .05): Women found the study of women as victim less ethical, and men found the study of men as rapist less ethical. In our second study, 30 noncollege women evaluated the research on women as rape victims. After reading the scenario, none of these women said they would have agreed to participate or thought the research was ethically acceptable. We discuss issues of informed consent, demands of the research situation, and potential benefits and risks.     

Social Density,Interpersonal Relationships,and Residential Crowding Stress1

Research has suggested that tripled rooms may be characterized by a coalition of two roommate(s) and a third, left-out rommate (i.e., the isolate) who is more vulnerable to crowding and control-related problems. The present study sought (1) to confirm the existence of two person coalitions in tripled rooms and (2) to further explore the mediating effects of interpersonal relationships on crowding stress and related problems. Thirty intact groups of roommates from doubled rooms (n= 60) and 39 intact groups of roommates from tripled rooms (n= 117) completed a set of surveys concerned with residential experiences. Results suggested that crowding stress previously associated with tripled residential settings may be mediated by interpersonal relationships; tripled residents who had negative interpersonal relationships with their roommates reported being more bothered by crowding, at both the beginning and end of the semester, than doubled residents who expressed negativity towards their roommate. Satisfaction with privacy was also influenced not only by the number of people with whom a resident shared a room, but also by the nature of the resident's interpersonal relationships with his/her roommate(s). Data also suggest that control-related problems may be a direct outcome of poor interpersonal relationships among inhabitants. Results also indicated that only a small percentage of tripled rooms were characterized by reciprocal, two person coalitions.     

Mediation of Social Density by Coalition Formation1

Past research has indicated that three-person groups are more likely to produce isolates than two-person groups, with isolates experiencing the greatest difficulties, least confidence, and most intense crowding stress. The present study extended these findings by examining the role of coalition formation as a mediator of social density in three- and four-person groups using a survey technique. As expected, coalition formation between two roommates, resulting in one or more isolates, was more likely to occur in three-person than four-person groups. Consistent with previous research, isolates in both three- and four-person groups reported more crowding, more somatic complaints, dissatisfaction with room and roommates, difficulty in maintaining control, and less confidence in their ability to regulate social interaction than nonisolates. Tripled isolates, however, consistently reported more significant feelings of not being understood by roommates and loneliness, as well as greater exclusion from group decisions, more extreme difficulties in maintaining control and regulating social interaction, and more intense crowding stress. Counterintuitively, with an increase in group size from three to four, reported crowding stress did not increase. Implications for group dynamic processes in ameliorating some of the problems associated with crowding stress are discussed.     

Tests that discriminate between dyslexic and other learning-disabled boys

Dyslexic and nondyslexic boys within a single community's learning-disabled class were given a set of tests; performance on each of these tests has been reported to be significantly impaired in other dyslexic children compared to learning-disabled and normal groups. Linear discriminant function analysis revealed that error types rather than levels of performance best separated the carefully matched learning-disabled groups. Slow naming and high percentage of “dysphasic” errors characterized dyslexic boys. Visual temporal-spatial matching and “configuration-deficient” perceptual errors characterized the adequate readers who have other learning disabilities.     

Sex of subject and gender identity as factors in humor appreciation

Appreciation of cartoon humor was examined in male and female college students who had been categorized into one of four gender identity groups (masculine, feminine, androgynous, undifferentiated) on the basis of Bem's Sex Role Inventory. Results indicated that males preferred sexual humor more than absurd humor, while females showed the reverse pattern. Furthermore, gender identity was related to humor appreciation only for females. While feminine females preferred absurd humor more than sexual humor, masculine and androgynous females were more appreciative of sexual humor. Finally, masculine, feminine, and undifferentiated males, as well as masculine and androgynous females, showed greater appreciation of sexual humor which portrayed females, as opposed to males, as the sex object or brunt of the joke.     

How “Regular” Is Sentence Comprehension in Broca's Aphasia? It Depends on How You Select the Patients

Grodzinsky, Piñango, Zurif, and Drai (1999) argue that a statistical analysis of pooled sentence comprehension data from published studies of Broca's aphasic patients supports the dominance of a differential pattern of performance on active and passive voice structures. They argue that these results counter a previous study in which individual patient data from published studies were analyzed. However, Grodzinsky et al. have not carried out a true test of their hypothesis, but have biased the outcome by selecting samples for analysis that support their claims.