Fibroblast growth factor-2 alters the nature of extinction

These experiments examined the effects of the NMDA-receptor (NMDAr) antagonist MK801 on reacquisition and re-extinction of a conditioned fear that had been previously extinguished before injection of fibroblast growth factor-2 (FGF2) or vehicle. Recent findings have shown that relearning and re-extinction, unlike initial learning and extinction, do not depend on NMDAr activation. Three experiments demonstrated that FGF2 prevents the switch from NMDAr-dependent to NMDAr-independent reacquisition and re-extinction, suggesting that FGF2 may lead to the partial erasure of the original fear memory. These findings add to a growing body of work suggesting that FGF2 may be a novel pharmacological enhancer of exposure therapy for humans with anxiety disorders.     

Pointing with the eyes: the role of gaze in communicating danger

Facial expression and direction of gaze are two important sources of social information, and what message each conveys may ultimately depend on how the respective information interacts in the eye of the perceiver. Direct gaze signals an interaction with the observer but averted gaze amounts to "pointing with the eyes", and in combination with a fearful facial expression may signal the presence of environmental danger. We used fMRI to examine how gaze direction influences brain processing of facial expression of fear. The combination of fearful faces and averted gazes activated areas related to gaze shifting (STS, IPS) and fear-processing (amygdala, hypothalamus, pallidum). Additional modulation of activation was observed in motion detection areas, in premotor areas and in the somatosensory cortex, bilaterally. Our results indicate that the direction of gaze prompts a process whereby the brain combines the meaning of the facial expression with the information provided by gaze direction, and in the process computes the behavioral implications for the observer.     

How to, and how not to, bridge computational cognitive neuroscience and Husserlian phenomenology of time consciousness

A number of recent attempts to bridge Husserlian phenomenology of time consciousness and contemporary tools and results from cognitive science or computational neuroscience are described and critiqued. An alternate proposal is outlined that lacks the weaknesses of existing accounts.     

Continuous Dynamics in Real-Time Cognition

ABSTRACT— Real-time cognition is best described not as a sequence of logical operations performed on discrete symbols but as a continuously changing pattern of neuronal activity. The continuity in these dynamics indicates that, in between describable states of mind, mental activity does not lend itself to the linguistic labels relied on by much of psychology. We discuss eye-tracking and mouse-tracking evidence for this temporal continuity and provide geometric visualizations of mental activity, depicting it as a continuous trajectory through a state space (a multidimensional space in which locations correspond to mental states). When the state of the system travels toward a frequently visited region of that space, the destination may constitute recognition of a particular word or a particular object; but on the way there, the majority of the mental trajectory is in intermediate regions of that space, revealing graded mixtures of mental states.     

The Self-Organization of Explicit Attitudes

ABSTRACT— How do minds produce explicit attitudes over several hundred milliseconds? Speeded evaluative measures have revealed implicit biases beyond cognitive control and subjective awareness, yet mental processing may culminate in an explicit attitude that feels personally endorsed and corroborates voluntary intentions. We argue that self-reported explicit attitudes derive from a continuous, temporally dynamic process, whereby multiple simultaneously conflicting sources of information self-organize into a meaningful mental representation. While our participants reported their explicit (like vs. dislike) attitudes toward White versus Black people by moving a cursor to a "like" or "dislike" response box, we recorded streaming x - and y -coordinates from their hand-movement trajectories. We found that participants' hand-movement paths exhibited greater curvature toward the "dislike" response when they reported positive explicit attitudes toward Black people than when they reported positive explicit attitudes toward White people. Moreover, these trajectories were characterized by movement disorder and competitive velocity profiles that were predicted under the assumption that the deliberate attitudes emerged from continuous interactions between multiple simultaneously conflicting constraints.     

Reducing attention‐maintained behavior through the use of positive punishment,differential reinforcement of low rates,and response marking

A differential reinforcement of low (DRL) rates procedure was implemented as a changing criterion design with positive punishment and response marking to reduce attention‐maintained behavior of screaming, profanity, and disruptive behaviors of three adolescent males. One participant was diagnosed with static encephalopathy and attention deficit hyperactivity disorder (ADHD) and severe mental retardation, the other two were diagnosed with Down syndrome, one with moderate mental retardation, and the other with severe mental retardation. Through response marking, a verbal warning was delivered immediately following the initial occurrence of a target behavior. A special token (positive punishment) was immediately delivered with a verbal cue and placed on a behavior board following the next occurrence of that behavior. Appropriate requests (hand‐raising) for attention was acknowledged and reinforced with verbal praise. The DRL procedure, combined with positive punishment and response marking, was successful in decreasing the frequency of targeted behaviors amongst all participants. Copyright © 2009 John Wiley & Sons, Ltd.     

Acute systemic fibroblast growth factor-2 enhances long-term memory in developing rats

Recent findings have provided much insight into the mechanisms underlying long-term memory formation, and it is now known that long-term memory depends on the activation of a molecular cascade that culminates with structural changes in the brain. However, little is known about the signals that give rise to or regulate these structural changes. In this article we propose that fibroblast growth factor-2 (FGF2), a mitogen for several cell types, may be one of the molecular signals critically involved in the structural changes underlying long-term memory. If FGF2 is part of the signalling cascade involved in long-term memory, then increasing the activation of FGF2 should facilitate memory. In Experiments 1 and 2, we demonstrated that systemic injection of FGF2 (20 ng/g of body weight) facilitated memory for contextual fear in 16, 19, and 22 day old male Sprague Dawley rats. Experiment 3 demonstrated that the observed facilitation of memory was not due to FGF2 increasing rats’ sensitivity to footshock. These results implicate FGF2 as a possible molecular signal in long-term memory, and further, illustrate a novel means of enhancing memory.     

GPS: A Randomized Controlled Trial of Sexual Health Counseling for Gay and Bisexual Men Living With HIV

Gay, bisexual, and other men who have sex with men (GBM) continue to have high rates of HIV and sexually transmitted infections, including syphilis. GBM have therefore been identified by public health agencies as a high-priority population to reach with prevention initiatives. Despite the importance of mental health in preventing HIV and related infections, there is a shortage of credentialed mental health professionals to deliver behavioral Counseling interventions. The current study evaluated the efficacy of GPS, a community-based and peer-delivered sexual health promotion motivational interviewing–based intervention for HIV-positive GBM who engaged in condomless anal sex (CAS) in the past 2 months. GPS prevention counseling demonstrated a 43% relative reduction at 3-month follow-up in CAS with serodiscordant partners and significant reductions in sexual compulsivity. The study demonstrated that community-based counselors can administer an efficacious motivational interviewing program, and suggests a continued benefit of counseling methods to promote the sexual health of higher risk populations.     

Trading relations in the perception of speech by 5-year-old children

Five-year-old children were tested for perceptual trading relations between a temporal cue (silence duration) and a spectral cue (F₁ onset frequency) for the “say-stay” distinction. Identification functions were obtained for two synthetic “say-stay” continua, each containing systematic variations in the amount of silence following the /s/ noise. In one continuum, the vocalic portion had a lower F₁ onset than in the other continuum. Children showed a smaller trading relation than has been found with adults. They did not differ from adults, however, in their perception of an “ay-day” continuum formed by varying F₁ onset frequency only. The results of a discrimination task in which the two acoustic cues were made to “cooperate” or “conflict” phonetically supported the notion of perceptual equivalence of the temporal and spectral cues along a single phonetic dimension. The results indicate that young children, like adults, perceptually integrate multiple cues to a speech contrast in a phonetically relevant manner, but that they may not give the same perceptual weights to the various cues as do adults.