Acute systemic fibroblast growth factor-2 enhances long-term memory in developing rats

Recent findings have provided much insight into the mechanisms underlying long-term memory formation, and it is now known that long-term memory depends on the activation of a molecular cascade that culminates with structural changes in the brain. However, little is known about the signals that give rise to or regulate these structural changes. In this article we propose that fibroblast growth factor-2 (FGF2), a mitogen for several cell types, may be one of the molecular signals critically involved in the structural changes underlying long-term memory. If FGF2 is part of the signalling cascade involved in long-term memory, then increasing the activation of FGF2 should facilitate memory. In Experiments 1 and 2, we demonstrated that systemic injection of FGF2 (20 ng/g of body weight) facilitated memory for contextual fear in 16, 19, and 22 day old male Sprague Dawley rats. Experiment 3 demonstrated that the observed facilitation of memory was not due to FGF2 increasing rats’ sensitivity to footshock. These results implicate FGF2 as a possible molecular signal in long-term memory, and further, illustrate a novel means of enhancing memory.     

Disciplined Litigation,Vigilant Litigation,and Deformation: Dramatic Organization Change in Jehovah's Witnesses

Jehovah's Witnesses' long‐term development presents an interesting case of evolution in line with the “deformation thesis,” an attempt at explaining dramatic shifts in organizational forms, activities, and even beliefs in controversial religious minorities. Derived from resource mobilization tradition, this thesis assumes that radical transformations result from major defensive resource allocation mandated by negative reactions of societal institutions. This is especially the case with reference to the adoption by Jehovah's Witnesses, a millenarian group, of a “disciplined litigation”strategy in the 1940s, a pattern later to be incorporated in religious activities and beliefs of the organization. Today, disciplined litigation and its successor, “vigilant litigation,” seem legitimate ways to adapt to the prevailing religious climate and structure. As such, it can be conceived as a model for defensive moves taken by “younger” controversial religious minorities and reflects the enormous influence of the law and legal systems in shaping minority religions.     

II—Thomas E. Uebel

ABSTRACT This response considers the question whether empiricists are condemned to silence about the epistemic agency their theories attribute or presuppose. It is argued that, unlike Reichenbach or Carnap, Neurath allowed for and indeed provided specifications of the role of epistemic agency in scientific inquiry. If this is correct, it underscores once more the need to distinguish between the various strands of logical positivism which show different strengths and weaknesses.     

Role of health locus of control beliefs and expectations of treatment efficacy in adjustment to cancer

We examined the effects of health locus of control beliefs (self-, doctor, and chance control) and expectations of treatment efficacy on short-term psychological adjustment in a sample of newly diagnosed cancer patients. The role of these beliefs and expectations in moderating the relation between (perceived and actual) disease severity and depression was also examined. The data were collected within one week of diagnosis. The relation between perceptions of disease severity and depression was weaker for those who believed that they could personally control their health and for those who held positive expectations about the effects of complying with medical treatment. Similar patterns were found when disease severity was defined in terms of prognosis for survival. Strong negative correlations between self-control/treatment expectations and depression were found for those who perceived that their illness was very severe. The results for chance and doctor control were less consistent. The stability of health control beliefs and treatment expectations over the course of a serious long-term illness is discussed.     

Rhesus monkeys (Macaca mulatta), video tasks, and implications for stimulus-response spatial contiguity

Recent reports (Iwai, Yaginuma, & Mishkin, 1986; Yaginuma & Iwai, 1986) have supported the earlier conclusion by Meyer, Treichler, and Meyer (1965) and by Stollnitz (1965) that the efficiency of primate learning is compromised to the degree that there is spatial discontiguity between discriminanda and the locus of response. The research reported in this article calls for a reconsideration of this conclusion. Two rhesus monkeys (Macaca mulatta) easily mastered precise control of a joystick to respond to a variety of computer-generated targets despite the fact that the joystick was located 9 to 18 cm from the video screen. We hold that stimulus-response contiguity is a significant parameter of learning only to the degree that the monkey visually attends to the directional movements of its hand in order to displace discriminanda as in the Wisconsin General Test Apparatus. If, instead, attention is focused on the effects of the hand's movement rather than on the hand itself, stimulus-response contiguity is no longer a primary parameter of learning. The implications of this work for mirror-guided studies are discussed.     

Aggression as One Response to Conflict1

This paper presents two studies that explore the link between self-reported conflict management strategies and aggression. It was predicted that conflict strategies involving concern for the needs of the other would be inconsistent with aggressive behavior. On the other hand, conflict strategies that involve coercion and domination were predicted to be positively related to aggressive behavior. Studies using self-report and behavioral measures of aggression provide support for these predictions.     

Parental and family predictors of behavior problems in inner-city black children

Studied contributions of maternal psychological distress, family stress load, maternal and family risk factors, and family coping strategies in predicting behavior problems in 441 inner-city black primary-grade children. Results indicated maternal psychological distress and high family stress load were associated with high child behavior problems. Family coping strategies offered no protection against risk, while coping with life difficulties by reframing them was detrimental to child behavioral adjustment. Active help-seeking strategies (i.e., family mobilization, acquiring social supports) served to moderate the effects of maternal psychological distress and family risk attributes for boys, but exacerbated the effects of dysfunctional maternal social and psychiatric histories for girls. Implications for understanding vulnerability and resilience in inner-city black children and recommendations for future research are discussed.