Characteristics and reversibility of dementia in Normal Pressure Hydrocephalus

Studies of the cognitive outcome after shunt insertion for treatment of Normal Pressure Hydrocephalus have reported widely mixed results. We prospectively studied performance of 60 patients with Normal Pressure Hydrocephalus on a comprehensive battery of neuropsychological tests before and after shunt surgery to determine which cognitive functions improve with shunt insertion. We also administered a subset of cognitive tests before and after temporary controlled drainage of cerebrospinal fluid to determine if change on this brief subset of tests after drainage could predict which patients would show cognitive improvement three to six months after shunt insertion. There was a significant improvement in learning, retention, and delayed recall of verbal memory three to six months after surgery (using paired t-tests). The majority (74%) of patients showed significant improvement (by at least one standard deviation) on at least one of the memory tests. Absence of improvement on verbal memory after temporary drainage of cerebrospinal fluid had a high negative predictive value for improvement on memory tests at 3-6 months after surgery (96%; p=0.0005). Also, the magnitude of improvement from Baseline to Post-Drainage on few specific tests of learning and recall significantly predicted the magnitude of improvement after shunt surgery on the same tests (r2=0.32-0.58; p=0.04-0.001). Results indicate that testing before and after temporary drainage may be useful in predicting which patients are less likely to improve in memory with shunting.     

Associative and repetition priming with the repeated masked prime technique: No priming found

Wentura and Frings (2005) reported evidence of subliminal categorical priming on a lexical decision task, using a new method of visual masking in which the prime string consisted of the prime word flanked by random consonants and random letter masks alternated with the prime string on successive refresh cycles. We investigated associative and repetition priming on lexical decision, using the same method of visual masking. Three experiments failed to show any evidence of associative priming, (1) when the prime string was fixed at 10 characters (three to six flanking letters) and (2) when the number of flanking letters were reduced or absent. In all cases, prime detection was at chance level. Strong associative priming was observed with visible unmasked primes, but the addition of flanking letters restricted priming even though prime detection was still high. With repetition priming, no priming effects were found with the repeated masked technique, and prime detection was poor but just above chance levels. We conclude that with repeated masked primes, there is effective visual masking but that associative priming and repetition priming do not occur with experiment-unique prime-target pairs. Explanations for this apparent discrepancy across priming paradigms are discussed. The priming stimuli and prime-target pairs used in this study may be downloaded as supplemental materials from mc.psychonomicjournals. org/content/supplemental.     

When self-disclosure goes awry: Negative consequences of revealing personal failures for lower self-esteem individuals

Despite the potential benefits of self-disclosure, individuals with lower self-esteem (LSEs) tend to avoid self-revelations. The present study investigated the role of self-esteem in predicting detrimental responses to the disclosure of a personal failure. We employed a novel experimental design where all participants experienced a lab-induced stressor (failure feedback on a competence test) and half were randomly assigned to disclose this information to their dating partner. In contrast to LSEs who concealed the personal failure, LSEs who disclosed the failure reported several negative consequences that may further contribute to relationship-based distress. However, individuals higher in self-esteem (HSEs) benefitted from disclosing the personal failure in comparison to LSEs who disclosed and HSEs who concealed the failure. We discuss the consequences of disclosing personal failures to partners for HSEs and LSEs.     

Acute systemic fibroblast growth factor-2 enhances long-term memory in developing rats

Recent findings have provided much insight into the mechanisms underlying long-term memory formation, and it is now known that long-term memory depends on the activation of a molecular cascade that culminates with structural changes in the brain. However, little is known about the signals that give rise to or regulate these structural changes. In this article we propose that fibroblast growth factor-2 (FGF2), a mitogen for several cell types, may be one of the molecular signals critically involved in the structural changes underlying long-term memory. If FGF2 is part of the signalling cascade involved in long-term memory, then increasing the activation of FGF2 should facilitate memory. In Experiments 1 and 2, we demonstrated that systemic injection of FGF2 (20 ng/g of body weight) facilitated memory for contextual fear in 16, 19, and 22 day old male Sprague Dawley rats. Experiment 3 demonstrated that the observed facilitation of memory was not due to FGF2 increasing rats’ sensitivity to footshock. These results implicate FGF2 as a possible molecular signal in long-term memory, and further, illustrate a novel means of enhancing memory.     

Development of the positive–negative asymmetry effect: in‐group exclusion norm as a mediator of children's evaluations on negative attributes

Two studies were conducted that go beyond previous research by examining when and why children might show intergroup bias in the attribution of positive, but not negative traits (PNAE: the positive–negative asymmetry effect, Mummendey & Otten, 1998, European review of social psychology, Vol. 9). In Study 1 (n = 107) children completed a ‘mixed’ trait attribution task in a dichotomous group context. As predicted there was a developmental trend between 7 and 12 years of age in the PNAE. The 7‐year olds were the only age group not to show the effect. Study 1 also found a quadratic developmental trend in children's national intergroup bias. Study 2 (n = 62) replicated the developmental path of the PNAE found in Study 1 using a wider age range of 6–16 years. This study used a ‘mixed’ list of traits which were not only antonyms and a procedure that made the positive and negative trait dimensions explicitly independent. Significantly, Study 2 found in‐group exclusion norm partially mediated the development of the PNAE. These findings support an account of the positive–negative asymmetry effect based upon normative processes. Copyright © 2006 John Wiley & Sons, Ltd.     

Disciplined Litigation,Vigilant Litigation,and Deformation: Dramatic Organization Change in Jehovah's Witnesses

Jehovah's Witnesses' long‐term development presents an interesting case of evolution in line with the “deformation thesis,” an attempt at explaining dramatic shifts in organizational forms, activities, and even beliefs in controversial religious minorities. Derived from resource mobilization tradition, this thesis assumes that radical transformations result from major defensive resource allocation mandated by negative reactions of societal institutions. This is especially the case with reference to the adoption by Jehovah's Witnesses, a millenarian group, of a “disciplined litigation”strategy in the 1940s, a pattern later to be incorporated in religious activities and beliefs of the organization. Today, disciplined litigation and its successor, “vigilant litigation,” seem legitimate ways to adapt to the prevailing religious climate and structure. As such, it can be conceived as a model for defensive moves taken by “younger” controversial religious minorities and reflects the enormous influence of the law and legal systems in shaping minority religions.