The neurophysiological validation of the hyperpolarization theory of internal inhibition

The experiments in conscious non-immobilized rabbits showed that cessation of the reactions without reinforcement (elaboration of the internal inhibition) is accompanied by an enhanced phasic state, by alternation of activation and inhibition of neuron firing, and by the corresponding slow potential oscillation (SPO). These changes can be either localized, predominantly in the structures of conditioned stimulus, or, under enhancement of the inhibitory state, generalized in the brain structures. On the basis of our experience and published data, it is concluded that the above event results from relative enhancement of the inhibitory hyperpolarizing processes due to increase in reactivity of the inhibitory systems to stimulus, which acquires inhibitory properties during learning. Changes in the excitability and reactivity of neuron populations appearing during enhancement of the hyperpolarizing inhibition, and differing in the various brain structures, play an active role in the execution of the main function of the internal inhibition: limitation of excitation transmission to the effectors. An inhibitory mediator gamma aminobutyric acid (GABA) is of great importance in inhibiting the excitation in response to the stimulus which lost its biological significance. These experimental data and their interpretation in the light of published data give the basis for the development of the hyperpolarization theory of internal inhibition.     

Extending neuropsychological assessments into the primary mental ability space

A battery of 17 neuropsychological tests (including the CERAD battery) and 17 psychometric ability tests were administered to a sample of 499 participants of the Seattle Longitudinal study who had been given the psychometric ability tests seven and 14 years earlier. The neuropsychological tests were projected into a 5-factor psychometric ability space by means of extension analysis. The concurrent regressions of the neuropsychology tests on the psychometric ability tests were then used to estimate neuropsychology test scores from the psychometric ability tests administered in 1984, 1991 and 1998. Neuropsychologists then rated the study participants as either normal, suspect or cognitively impaired in 1998. Changes in estimated test scores were computed over seven and fourteen years. Significant odds ratios between normal and cognitively impaired groups were found for all neuropsychological tests over the proximal period and for most tests over the 14-year period. Similar findings occurred for the odds ratios between the normal and suspect groups for the most proximal 7-year changes.     

Structural brain variation,age, and response time

Response time (RT) generally slows with aging, but the contribution of structural brain changes to this slowing is unknown. We used voxel-based morphometry (VBM) to determine gray matter (GM) and white matter (WM) brain volumes in 9 middle-aged adults (38–58 years old) and 9 seniors (66–82 years old). We correlated brain volumes with RT assessed in both a simple visual stimulus-response task and a visual continuous recognition memory task. No GM correlations with simple RT were significant; there was one WM correlation in the right fusiform gyrus. In the memory task, faster RT was correlated (p<.05, corrected) with less GM in the globus pallidus, the parahippocampus, and the thalamus for both groups. Several Brodmann areas (BA) differed between the groups such that in each area, less GM was correlated with slower RTs in the middle-aged group but with faster RTs in the senior group (BAs 19, 37, 46, 9, 8, 6, 13, 10, 41, and 7). The results suggest that individual differences in specific brain structure volumes should be considered as potential moderating factors in cognitive brain imaging studies.     

An automated version of the operation span task

We present an easy-to-administer and automated version of a popular working memory (WM) capacity task (operation span; Ospan) that is mouse driven, scores itself, and requires little intervention on the part of the experimenter. It is shown that this version of Ospan correlates well with other measures of WM capacity and has both good internal consistency (alpha=.78) and test-retest reliability (.83). In addition, the automated version of Ospan (Aospan) was shown to load on the same factor as two other WM measures. This WM capacity factor correlated with a factor composed of fluid abilities measures. The utility of the Aospan was further demonstrated by analyzing response times (RTs) that indicated that RT measures obtained in the task accounted for additional variance in predicting fluid abilities. Our results suggest that Aospan is a reliable and valid indicator of WM capacity that can be applied to a wide array of research domains.     

Validity of test score interpretations for three self-concept measures based on differing theoretical models

Three theoretical models have been proposed to represent self-concept: (a) unidimensional; (b) multidimensional; (c) multidimensional hierarchical. Inventories have been developed under each of the three competing theoretical models; which model best represents self-concept is unclear. Typically, self-concept construct validation has utilized various approaches including correlational, multitrait-multimethod, and factor analytic methods. Another method, however, for assessing validity would be to determine the consequences of score interpretations using different measures specific to each of the theoretical models. This paper examined Messick's notion (1989) of the validity of test-score interpretations as applied to three of the most widely used measures derived under each of the three different theoretical models of self-concept. Results suggest that overall multidimensional measures are more consistent in classifying individual's self-concept than unidimensional measures.