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891.
The modulation of attacks, genital sniffs, and mounts in male SJL/J mice by ovarian-dependent urogenital substances in the urine voided by estrous females was examined. Urogenital substances were applied onto the external urogenital areas of ovariectomized mice. When compared with urine voided by estrous females, which stimulated genital sniffing, mounting, and reduced aggression, bladder urine was ineffective. Genital sniffing and mounting was stimulated by estradiol-17 beta, vaginal fluids, and preputial extract. Aggression was reduced by estradiol-17 beta, urethral catheterized urine, and vaginal fluids. Preputialectomy reduced, but did not eliminate, urinary stimulation of genital sniffing and mounting. Preputial extract stimulated aggression. Urogenital substances from ovariectomized females were ineffective in reducing attacks and stimulating genital sniffs and mounts. It was concluded that the ovarian-dependent chemosignals in the urine voided by estrous females are contributed by the urethra, vagina, and preputial gland, perhaps in part through the excretion of unconjugated estrogens. 相似文献
892.
Wistar rats of three age groups were tested in an automated tunnel-maze system of variable geometry to investigate whether changes in spontaneous locomotor activity and in learning and memory develop differentially or in a correlated fashion as a function of age. Senescent (30 months) as well as mature-adult (17 months) rats showed an age-correlated decline of locomotor activity as compared to the mature-young (5 months) group. Both working-memory (measured as within-trial arm discrimination performance) and reference-memory (measured as avoidance of "blind alley" visits) were severely affected in the senescent group, whereas the middle-aged animals suffered only from a working-memory deficit. The findings provide evidence that locomotor deficits do not necessarily interfere in the assessment of age-related changes in cognitive performance. Furthermore the results support the hypothesis that working and reference memory have different underlying physiological correlates and that these neuronal systems are differentially affected by the aging process. 相似文献
893.
Serotonergic and opiate interactions in the modulation of drug- and environmental-induced analgesia were assessed in 6-day-old Sprague-Dawley-derived rat pups using tail-flick testing procedures. In these experiments the serotonergic antagonist metergoline was observed to attenuate both the analgesia induced by the opiate agonist morphine and the analgesia induced by isolation from siblings and the dam, an environmental manipulation which has previously been shown to be associated with increases in opiate activity. In contrast, the opiate antagonist naloxone was observed to be ineffective in blocking not only analgesia induced by the serotonergic agonist quipazine, but also analgesia induced by long-term deprivation from the dam and food, a manipulation that has been previously reported to induce increases in serotonergic utilization. These results suggest that in the neonate, as in the adult, the serotonergic modulation of nociception appears to occur "downstream" from the opiate systems serving to regulate nociception following both drug- and environmental-induced alterations in pain sensitivity. Analgesia induced by long-term deprivation from food and the dam appears to be strongly related to increases in serotonergic activity and relatively unaffected by opiate antagonism, whereas analgesia induced by isolation from siblings and the dam may be related to increases in opiate activity, but modulated by serotonergic systems serving to regulate pain responsivity. Thus alterations in the environment, mediated at least in part by alterations in opiate and serotonergic activity, appear to play an important role in influencing the sensitivity of the neonate to pain stimuli. 相似文献
894.
Recent research has indicated strong relations between people's appraisals of their circumstances and their emotional states. The present study examined these relations across a range of unpleasant situations in which subjects experienced complex emotional blends. Subjects recalled unpleasant experiences from their pasts that were associated with particular appraisals and described their appraisals and emotions during these experiences. Situations defined by particular appraisals along the human agency or situational control dimensions were reliably associated with different levels of anger, sadness, and guilt, as predicted. However, predicted differences in emotion were not observed for situations selected for appraisals along the certainty or attention dimensions. Most subjects reported experiencing blends of two or more emotions, and correlation/regression analyses indicated that even in the context of these blends, patterns of appraisal similar to those observed previously (Smith & Ellsworth, 1985, 1987) characterized the experience of the individual emotions. The regressions further indicated that appraisals along some dimensions were more important to the experience of particular emotions than were appraisals along other dimensions. Thesecentral appraisals are compared with the adaptive functions their associated emotions are believed to serve, and the implications of these findings are discussed.This research was supported in part by a Stanford University graduate fellowship and in part by a National Institute of Mental Health training grant to Craig Smith. Part of the writing was done while Phoebe Ellsworth was a fellow at the Center for Advanced Study in the Behavioral Sciences, supported by the John D. and Catherine T. MacArthur Foundation and by the James McKeen Cattell Fund. 相似文献
895.
The development of the understanding of affective meaning in music was investigated. Subjects aged 4, 5, 6, and 19 assigned verbal labels to musical segments previously determined by adults to be representative of one of four affects (happy, sad, angry, afraid). Analysis of correct interpretations and errors revealed a pattern of interactions among age, sex, and affect indicating that the ability to verbalize an understanding of affective meaning in music consistent with that of adult subjects is present during the preschool years. Age-related similarities in performance, as well as differences favoring both younger and older subjects, were observed and were discussed in relation to recent research in, and theories of, affective development and communication.The authors thank H. Julia Hannay, Edward Kemery, Shiela MacDonald, and Robert McGrath for their assistance in this research. The conceptual inspiration of Joseph Intrieri is gratefully acknowledged. We also thank Leslie Brody, Robin Hornik, and several anonymous reviewers for their comments on an earlier draft of the paper. Portions of this research were presented at the Southeastern Conference on Human Development, Baltimore, April 1982. 相似文献
896.
Two experiments replicated Ekman and Friesen's finding of an expression that signals contempt across cultures. The subjects, from West Sumatra, Indonesia, were members of a culture that differs in a number of ways from Western cultures. In one experiment the subjects judged photographs of Japanese and American faces, both males and females, which showed many different emotions. There was very high agreement about which expressions signaled contempt in preference to anger, disgust, happiness, sadness, fear, or surprise. In a second experiment the Indonesian subjects judged expressions shown by members of their own culture, and again there was very high agreement about which expression signals contempt.This study was supported by a grant from the National Institute of Mental Health (MH 41100). Paul Ekman's work is also supported by a Research Scientist Award from the National Institute of Mental Health (MH 06092). Karl G. Heider's work was supported by a grant from the National Institute of Mental Health (MH 38221). We are grateful to Maureen O'Sullivan for her many helpful comments on this report. 相似文献
897.
898.
A 47-year-old right-handed man underwent craniotomy for clipping of an aneurism at the trifurcation of the left middle cerebral artery. Subsequently, he suffered a left hemisphere CVA after which his speech and language resembled that of Broca's aphasia with accompanying apraxia of speech. Medical, behavioral, and acoustical data amassed over a period of several months indicated numerous contraindications to traditional diagnoses of Broca's aphasia, apraxia of speech, and dysarthria. Ultimately, it was determined that the patient had a selective impairement of phonation or laryngeal apraxia. This was illustrated dramatically when he was taught to use an electrolarynx which allowed him to bypass his disrupted phonatory system. Speaking with the electrolarynx, the patient communicated normally. Any semblance of Broca's aphasia disappeared. Supralaryngeal articulation was normal; apraxia of speech behaviors were absent. This case report indicates that dissociation of oral and laryngeal gestures due to brain injury is possible. Mechanisms underlying such a dissociation for this case are reviewed. The possibility of discrete center lesions in the frontal motor association area causing different types of apraxia of speech is discussed. 相似文献
899.
900.
The ability of right-brain-damaged (RBD) subjects to correctly insert a word into a well-formed stimulus sentence was tested. Subjects also performed three evaluative tasks designed to establish their degree of general cognitive impairment. The performance of RBD subjects on these tasks was compared to that of left-brain-damaged (LBD) and non-brain-damaged (NBD) subjects. Although RBD subjects outperformed LBD subjects on the language-related evaluative tasks, the RBD group was significantly more impaired on a subset of the insertion task. This subset included items which required reassignment of the syntactic status of elements in the stimulus sentence in order for the insertion to be carried out. The results of this study permit refinement of the common characterization of RBD individuals as rigid in their interpretation of meaning and indicate right-hemisphere involvement in aspects of the grammar previously thought to be inaccessible to it. 相似文献