Energetic and motor responses to increasing force requirements

The effects of increasing work (force) requirements on energy expenditure and response topography were examined in 7 rats pressing a beam to earn food. For the 1st 16 days, the force requirement was 5.52 x 10(-2) N (5.625 g). This increased by 4.91 x 10(-2) N (5 g) every 7th session until Ss had experienced 10 upward shifts. Following the 54.57 x 10(-2) N (55.625 g) condition, the original criterion was reinstated. During the augmented phase. Ss maintained stable reinforcement rates across conditions by increasing the peak force of beam pressing. These higher forces, occurring within 20 reinforcements of changing the force criterion, were produced primarily by increases in the rate of change of force (delta F/delta T). Also, while the rate of work performed on the beam increased, the overall energy expenditure fell. In contrast to these rapid adjustments, reinstating the original 5.52 x 10(-2) N (5.625 g) criterion resulted in only gradual alterations in motor performance.     

The enhancement of retention induced by vasopressin in mice may be mediated by an activation of central nicotinic cholinergic mechanisms.

Immediate post-training subcutaneous administration of lysine vasopressin (LVP, 0.003-1.00 microgram/kg) enhanced retention, whereas the vasopressin antagonist AAVP (0.01-0.30 microgram/kg) impaired it, in male Swiss mice tested 48 h after training in an inhibitory avoidance task. Both effects were dose-dependent. Neither LVP nor AAVP affected response latencies in mice not given the footshock on the training trial. The simultaneous administration of AAVP at a dose (0.01 microgram/kg) which had no effect on retention shifted the dose-response curve of LVP to the right. Nicotine (1.0-30.0 micrograms/kg, sc), a central nicotinic cholinergic agonist, also facilitated retention in a dose-related manner without affecting the retention performance of unshocked mice. The effect of nicotine was prevented by the central acting nicotinic cholinergic receptor antagonist mecamylamine (5 mg/kg, sc.). In contrast, neither hexamethonium (5 mg/kg, sc), a peripheral acting nicotinic receptor blocker, nor atropine (0.5 mg/kg, sc) or methylatropine (0.5 mg/kg, sc), two anticholinergic drugs which are known to act on muscarinic cholinergic receptors, prevented the effect of post-training nicotine. The effects of LVP and nicotine were time-dependent, suggesting that both treatments enhanced retention by influencing post-training processes involved in memory storage. Low doses of nicotine (1.50 microgram/kg, sc) or the central anticholinesterase physostigmine (35 micrograms/kg, sc) and LVP (0.003 microgram/kg, sc), which had no effect on retention when administered alone, produced a synergistic interaction when given together following training. The influence of LVP (0.03 microgram/kg, sc) on retention was prevented not only by AAVP (0.01 microgram/kg, sc) but also by mecamylamine (5 mg/kg, sc), whereas the effects of nicotine (10.0 micrograms/kg, sc) were prevented only by mecamylamine. These results suggest that the enhancement of retention induced by vasopressin is probably due to an activation of central nicotinic cholinergic mechanisms which are critical for memory formation.     

Sequencing of behaviors in Aplysia fasciata: integration of feeding, reproduction, and locomotion.

To begin studying the neural basis of higher-order decision-making in Aplysia fasciata, we examined individual bouts of behavior in various conditions of access to food and/or mates. We then determined rules governing transitions between bouts. The data indicate that a single intermediate condition, moving in place, may be centrally related to transitions between behaviors. In all conditions, over 85% of all transitions between behaviors were via moving in place. Moving in place tended to precede and follow other categories of activity (crawling, swimming, immobile), and feeding. Also, moving in place apparently represents a fixed proportion of all bouts of behavior. In each condition, moving in place represented approximately 40% of all bouts, while the number of bouts of other behaviors varied markedly. After a bout of moving in place there was a strong tendency for the animal to return to the behavior performed before moving in place. Additional preferred sequences of behavior were also seen. Courtship tended to precede mating, and crawling preceded swimming.     

Sexual experience effects are blocked both by the protein-synthesis inhibitor, cycloheximide, and by the noncompetitive NMDA antagonist, MK-801.

Three studies were done to determine the effects of a brief 2-h sexual experience on the maintenance of sexual behavior in male rats; the effects on the experience-based maintenance of sexual behavior of gonadal hormones (study 1), a protein-synthesis inhibitor (study 2), and an N-methyl-D-aspartate receptor blocker (study 3) were determined. Naive male rats were provided with a 2-h sexual experience with sexually receptive hormonally "primed" females or they received no experience. In the first study animals under each of these conditions then underwent castration or sham surgery. In the second study animals under each of the experience conditions received either cycloheximide (CYX) or saline (SAL; 1.5 or 3.0 mg/kg CYX or SAL sc, 10 min after the experience). In study 3 experienced and inexperienced animals received either 0.07 or 0.10 mg/kg MK-801 ip (15 min before the experience). In all studies animals were tested for sexual behavior 3, 6, and 9 days after surgery or injection. These studies showed that the most consistent effect of a 2-h sexual experience was to facilitate the initiation of mounting, especially on the first test; they show, further, that most experience effects were reduced or eliminated if animals were castrated between experience and test, if they received a drug (CYX) at the time of the experience that blocks the synthesis of proteins, or if they received an NMDA receptor antagonist prior to the experience.     

Exceptional calendar calculation ability after early left hemispherectomy

An 18-year-old male subject who had had his left hemisphere removed at age eight was better than chance at calculating the day of the week upon which dates in the past and future fell. He was able to describe his method of calculation, which relied upon both visual memory and serial calculations. The use of a serial calculation method was supported by evidence that both response time and accuracy were related to the distance in years from the current year. The use of both visual and verbal "working" memory was supported by interference effects from calendar calculations and delayed visual and verbal memory tasks. The case is discussed in terms of theories regarding similar calculation skills in idiot savants.     

Scopolamine intoxication as a model of transient global amnesia

In Colombia (South America) during recent decades the administration of scopolamine, extracted from plants belonging to the Datura or Brugmansia genus, has become an important neurologic and toxicologic phenomenon. These extracts have been popularly known as "Burundanga." Chemical characteristics and clinical features of scopolamine intoxication are described. Anterograde amnesia and submissive behavior found in patients intoxicated with scopolamine are analyzed. Burundanga intoxication is related to other toxic phenomena found in different countries and similitudes with transient global amnesia are emphasized.     

Strategies for Counseling Infertile Couples

Approximately one in six couples experience problems with their fertility in terms of conceiving and/or carrying a viable pregnancy to term. The infertile couple's need for counseling and support has been emphasized consistently in the literature. This article presents specific intervention strategies that may serve to reinforce the infertility experience as an opportunity for personal and marital growth.     

Successful Resolutions to the Career-Versus-Family Conflict

One hundred and twenty husbands and wives (60 couples) were individually assessed on how conflicted (or resolved) they were about the career-versus-family conflict in their lives. Their written resolutions were also content-analyzed to extract specific themes and conflict-resolution strategies. Data on participants' self-esteem, conflict-related anxiety, life satisfaction, and demographic variables were also collected. Results of t tests, chi-squares, Pearson correlations, and a stepwise multiple regression analysis indicated that high self-esteem and life satisfaction best predicted being resolved about the conflict. The only theme that discriminated between the most and least resolved spouses was “my family comes first” (held by the most resolved). Wives were more rationally resolved about the conflict than their husbands.     

Adult age differences in letter-level and word-level processing

Older and young adults' letter detection and lexical decision performance were examined as word frequency varied to determine whether there were age differences in word recognition. Allen and Madden (1989) found that older adults' pattern of reaction time (RT) across word frequency categories was different from young adults' pattern for a letter detection task. In this study, for both letter detection and lexical decision tasks, older adults exhibited a monotonically decreasing RT function as word frequency increased. However, young adults exhibited a nonmonotonic RT function across word frequency for the letter detection task but a monotonically decreasing RT function as word frequency increased for the lexical decision task. An expanded parallel input serial analysis model of word processing was hypothesized.     

Multiculturalism and Rehabilitation Counselor Training: Recommendations for Providing Culturally Appropriate Counseling Services to American Indians With Disabilities

American Indians exhibit health-related problems at younger ages, as compared with the general population. They also have a disproportionate number of deaths related to alcoholism, accidents, homicides, pneumonia, influenza, diabetes mellitus, and tuberculosis as compared with the general population. In terms of mental health, depression and adjustment reactions are common problems, with the suicide rate among American Indian adults being more than twice as high as that for the general population. This article delineates specific steps necessary to successfully recruit and retain American Indians in counselor training programs, proposes a curriculum for training counselors to effectively provide services to American Indians with disabilities, and discusses the responsibility of counselor educators to concern themselves with the “job placement” of their graduates. En comparación con la población engeneral, los indios americanos tienen problemas de salud a edades más jovenes y tienen un número de mortandad deproporcionada debida al alcoholismo, acidentes, homicidios, neumonía, gripe, diabetes mellitus, y tuberculosis. En terminos de salud mental, reaciones a depresión y adaptación son problemas comunes, con la media de suicidios superior al doble de la cifra para la población general. Este artículo delinea medidas específicas que son necesarias para atraer y retener indios americanos en programas de entrenamiento de consejería, propone un programa para entrenar consejeros para el suministro eficaz de servicios a indios americanos incapacitados, y discute la responsabilidad de los educadores de consejeros para implicarlos en la búsqueda de un empleo para sus graduados.