全文获取类型
收费全文 | 440篇 |
免费 | 53篇 |
出版年
2024年 | 4篇 |
2023年 | 12篇 |
2022年 | 6篇 |
2021年 | 12篇 |
2020年 | 23篇 |
2019年 | 13篇 |
2018年 | 31篇 |
2017年 | 41篇 |
2016年 | 18篇 |
2015年 | 15篇 |
2014年 | 14篇 |
2013年 | 47篇 |
2012年 | 38篇 |
2011年 | 32篇 |
2010年 | 14篇 |
2009年 | 6篇 |
2008年 | 16篇 |
2007年 | 19篇 |
2006年 | 12篇 |
2005年 | 7篇 |
2004年 | 8篇 |
2003年 | 12篇 |
2002年 | 9篇 |
2001年 | 7篇 |
2000年 | 3篇 |
1999年 | 9篇 |
1998年 | 4篇 |
1997年 | 5篇 |
1996年 | 4篇 |
1994年 | 1篇 |
1993年 | 5篇 |
1992年 | 7篇 |
1990年 | 4篇 |
1989年 | 6篇 |
1988年 | 3篇 |
1987年 | 6篇 |
1986年 | 3篇 |
1985年 | 3篇 |
1984年 | 4篇 |
1983年 | 2篇 |
1981年 | 1篇 |
1979年 | 1篇 |
1978年 | 1篇 |
1977年 | 1篇 |
1976年 | 1篇 |
1964年 | 1篇 |
1963年 | 1篇 |
1933年 | 1篇 |
排序方式: 共有493条查询结果,搜索用时 15 毫秒
421.
422.
423.
Lima FS Simioni S Bruggimann L Ruffieux C Dudler J Felley C Michetti P Annoni JM Schluep M 《Behavioural neurology》2007,18(2):81-90
Acquired behavioral changes have essentially been described in advanced multiple sclerosis (MS). The present study was designed to determine whether behavioral modifications specifically related to the MS pathological process could be identified in the initial phase of the disease, as compared to control patients with chronic, relapsing and progressive inflammatory disorders not involving the central nervous system (CNS). Eighty-eight early MS patients (Expanded Disability Status Scale score 相似文献
424.
Eighteen examiners, well trained in the Comprehensive System (CS; Exner, 2003), administered the Rorschach to 357 Portuguese children, in the first through fifth grades, attending schools located in Lisbon and the surrounding neighborhood. Coding was done by 5 of the examiners, each one having more than 5 years of experience with the CS. For this study, coding was reviewed by the authors. Five records were randomly selected from each age group to assess intercoder reliability. Janson and Olsson's (2004) iota was used to assess reliability of the main variable categories. Results are high, with iota ranging from 0.87 to 0.98 across the coding categories. CS variables are presented and key data were chosen and reviewed. A discussion of some data and their comparison with corresponding American data are made, permitting some interesting developmental and cross-cultural questions to be addressed. 相似文献
425.
In the centennial year of the birth of Hans Selye, this review compares his classical concepts of stress with a modern approach to mechanisms of CNS arousal. Relations between the two concepts are described. Neuroanatomical, neurophysiological, and functional genomic mechanisms underlying CNS arousal are briefly reviewed. Controls over stress responses and arousal are compared to particular concepts of control system engineering. Understanding these two systems is of crucial importance because their dysregulation is associated with large numbers of disease states. 相似文献
426.
Da Cunha C Wietzikoski S Wietzikoski EC Silva MH Chandler J Ferro MM Andreatini R Canteras NS 《Neurobiology of learning and memory》2007,87(4):451-463
The bilateral intranigral infusion of 1 micromol 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) in adult male Wistar rats caused a specific and partial loss of substantia nigra pars compacta (SNc) dopamine neurons, a partial depletion of striatal dopamine, and a deficit to learn the intra-maze cued version of the Morris water maze. Pre-training the SNc rats in the spatial version of the water maze or simply maintaining the animals on the water maze platform reversed this deficit. This improvement was even observed when the order of the extra-maze cues presented to the rats during pre-training of the spatial version was changed during training of the intra-maze cued version. However, this deficit was not reversed either by maintaining the animals on the platform if the spatial cues were surrounded and covered with a curtain or by swimming sessions in the maze without the escape platform and the curtain. These findings suggest that none of the following elements alone, learned during the spatial task pre-training, could help SNc rats learn the intra-maze cued task: improvement of swimming skills or knowledge of the existence of the escape platform; distance between the platform and the border of the pool; location of a particular extra-maze cue; relations among extra-maze cues. However, the simultaneous presence of the escape platform and extra-maze cues (irrespective of their relational configuration) during the pre-training sessions proved to be necessary for this improving effect to occur. 相似文献
427.
Although the changes in kinematics of infant reaching have been studied, few researchers have investigated the improvement of reaching regarding objects of distinct physical properties. The aim of this longitudinal study was to verify the impact of object size and rigidity on the development of reaching in 4-6-month-old infants. Four infants were observed with a motion capture system during trials with four objects of distinct sizes and rigidity. A total of 188 reaches were analyzed by using the 3D movement reconstruction. Our results showed that reaching frequency, mean velocity, and straightness index increased with age. The number of movement units decreased with age and increased for small objects. Rigidity was not shown to affect reaching trajectories. These findings suggest that infants are capable of perceiving the more relevant object properties, thus using their available motor capabilities to modify the essential variables so that they can reach the target more accurately. 相似文献
428.
Trace eyeblink conditioning requires the hippocampus but not autophosphorylation of alphaCaMKII in mice 下载免费PDF全文
Ohno M Tseng W Silva AJ Disterhoft JF 《Learning & memory (Cold Spring Harbor, N.Y.)》2005,12(3):211-215
Little is known about signaling mechanisms underlying temporal associative learning. Here, we show that mice with a targeted point mutation that prevents autophosphorylation of alphaCaMKII (alphaCaMKII(T286A)) learn trace eyeblink conditioning normally. This forms a sharp contrast to the severely impaired spatial learning in the water maze and contextual fear conditioning observed in alphaCaMKII(T286A) mutants. Importantly, hippocampal lesions impaired trace eyeblink conditioning in alphaCaMKII(T286A) mice, suggesting a potential role of hippocampal alphaCaMKII-independent mechanisms. These results indicate that hippocampal signaling mechanisms that underlie temporal associative learning as assessed by trace eyeblink conditioning may differ from those of spatial and contextual learning. 相似文献
429.
Activation of MAPK is necessary for long-term memory consolidation following food-reward conditioning 下载免费PDF全文
Ribeiro MJ Schofield MG Kemenes I O'Shea M Kemenes G Benjamin PR 《Learning & memory (Cold Spring Harbor, N.Y.)》2005,12(5):538-545
Although an important role for the mitogen-activated protein kinase (MAPK) has been established for memory consolidation in a variety of learning paradigms, it is not known if this pathway is also involved in appetitive classical conditioning. We address this question by using a single-trial food-reward conditioning paradigm in the freshwater snail Lymnaea stagnalis. This learning paradigm induces protein synthesis-dependent long-term memory formation. Inhibition of MAPK phosphorylation blocked long-term memory consolidation without affecting the sensory and motor abilities of the snails. Thirty minutes after conditioning, levels of MAPK phosphorylation were increased in extracts from the buccal and cerebral ganglia. These ganglia are involved in the generation, modulation, and plasticity of the feeding behavior. We also detected an increase in levels of MAPK phosphorylation in the peripheral tissue around the mouth of the snails where chemoreceptors are located. Although an increase in MAPK phosphorylation was shown to be essential for food-reward conditioning, it was also detected in snails that were exposed to the conditioned stimulus (CS) or the unconditioned stimulus (US) alone, suggesting that phosphorylation of MAPK is necessary but not sufficient for learning to occur. 相似文献
430.