Ipsilesional Arm Motor Sequence Performance After Right and Left Hemisphere Damage

Aiming movements are part of daily activities but the brain hemispheres’ role in targeted aiming sequential movements is not fully clear. Start and execution of discrete and sequential tasks toward targets were analyzed in 10 individuals with left-hemisphere damage, 10 right-hemisphere–damaged, and 10 healthy ones. Arm movements were performed over a digitizing tablet, following stimuli on a monitor, from initial position toward right and left-positioned targets. Poststroke individuals used their ipsilesional arm and healthy individuals, both arms. Right-hemisphere–damaged individuals showed higher reaction time and left-hemisphere–damaged individuals, lower smoothness. Due to spatial demand of tasks, the right hemisphere played a major role in movement planning, while the left, in movement execution.     

Tower of London test: a comparison between conventional statistic approach and modelling based on artificial neural network in differentiating fronto-temporal dementia from Alzheimer's disease

The early differentiation of Alzheimer's disease (AD) from frontotemporal dementia (FTD) may be difficult. The Tower of London (ToL), thought to assess executive functions such as planning and visuo-spatial working memory, could help in this purpose. Twentytwo Dementia Centers consecutively recruited patients with early FTD or AD. ToL performances of these groups were analyzed using both the conventional statistical approaches and the Artificial Neural Networks (ANNs) modelling. Ninety-four non aphasic FTD and 160 AD patients were recruited. ToL Accuracy Score (AS) significantly (p < 0.05) differentiated FTD from AD patients. However, the discriminant validity of AS checked by ROC curve analysis, yielded no significant results in terms of sensitivity and specificity (AUC 0.63). The performances of the 12 Success Subscores (SS) together with age, gender and schooling years were entered into advanced ANNs developed by Semeion Institute. The best ANNs were selected and submitted to ROC curves. The non-linear model was able to discriminate FTD from AD with an average AUC for 7 independent trials of 0.82. The use of hidden information contained in the different items of ToL and the non linear processing of the data through ANNs allows a high discrimination between FTD and AD in individual patients.     

The Impact of Culture on the Individual Subjective Well-Being of the Italian Population: An Exploratory Study

The aim of this study is to explore the relationship between cultural access and individual psychological well-being, in order to provide a possible estimation of the impact of cultural participation upon subjective perceptions of well being. Our exploratory research was based on a cross-sectional survey undertook on a medium-large sample (n = 1500) of Italian residents in fall 2008. We refer to the Psychological General Well-Being Index–PGWBI, a tool that has been validated through 30 years of research, as an index of measurement. Moreover, we have administered to the sample an additional questionnaire inquiring about access to 15 distinct culturally related activities. Data are processed by means of a specific methodology based on ANN and Called TWIST. TWIST has been developed by the Semeion Research Center, Rome. Our analysis suggests that culture has a relevant role as a determinant of individual psychological well-being, in that a selected subset of cultural variables turn out to perform among the best predictors of individual PGWB levels. Our results also allow some preliminary considerations about innovative, well-being focused public health policies leveraging upon the human and social developmental role of culture.     

A systematic review of motivational interviewing within musculoskeletal health

Motivational interviewing (MI) has been investigated within a range of healthcare environments though to date no studies have systematically assessed its application and effectiveness within musculoskeletal health. The aim of this study is to identify interventions that have utilised MI to create change within musculoskeletal healthcare, evaluate quality and effectiveness, as well as identify the level of training received by those utilising the approach. The search strategy identified both published and unpublished or grey literature through electronic resources, reference list and content searches. Five studies were identified for quality assessment. Due to variations in delivery modality, musculoskeletal condition and type of MI application it was not possible to provide direct comparative interpretations for these factors. A data synthesis was used to provide a summary of study characteristics, a narrative overview and conduct a quality assessment as well as considering authors comments on study limitations. The results of the quality assessment highlighted a number of methodological issues which supported and expanded upon those expressed by the studies authors. None of the studies contained children or young people and in terms of training there were variations in training provider, duration and competency, as well as variation in the fidelity of MI. The findings have highlighted the need for well designed randomised controlled trials that are suitability powered to measure the effectiveness of MI within musculoskeletal health. Future studies may consider the application of MI within musculoskeletal conditions in terms of self-management and its application to creating lifestyle changes (e.g., diet, exercise) for adults, as well as children and young people. Research currently being conducted may expand upon the evidence, feasibility and validity of MI within areas such as fibromyalgia, osteoporosis, arthritis, understanding of knee replacement and rehabilitation.     

Undone Science and Counter-Expertise: Fighting for Justice in an Argentine Community Contaminated by Pesticides

ABSTRACT

STS and social movement scholars have shown the importance of ‘getting undone science done’ to advance the goals of social movements fighting environmental health injustice. The production and mobilization of counter-expertise, meaning the reliance on expertise, broadly construed, to contest regulatory decisions based on scientific knowledge, must be further analyzed by differentiating among types of expertise and strategies to mobilize them. In social mobilization against the unrestricted use of pesticides in Argentina, the affected community in Ituzaingó Anexo developed three types of expertise. The community first drew upon its own local knowledge of cases of illness and, as lay people, produced the first epidemiological map of this area. Then, they enrolled scientists and NGOs as allies to jointly learn about pesticide contamination as an explanation for illness. The enlisted scientists produced new knowledge by conducting environmental and epidemiological studies. Finally, sympathetic public health authorities, legal experts, and a district attorney designed a successful legal strategy to stop fumigations in that area and enforce local regulations. The case confirms the importance of producing undone science, and shows that its effectiveness can be explained by intertwined strategies deployed by a triad of lay/local, scientific, and legal experts to overcome the expertise barrier.