Re-emergence of extinguished auditory-cued conditioned fear following a sub-conditioning procedure: effects of hippocampal and prefrontal tetanic stimulations

Post-extinction exposure of rats to a sub-conditioning procedure can evoke conditioned fear, which may correspond to fear return and/or fear learning potentiation. The aim of the present study was to clarify this issue and examine the effects of tetanic stimulation of the hippocampus (HPC) and medial prefrontal cortex (mPFC), two brain regions implicated in post-extinction modulation of conditioned fear. Rats were initially submitted to five tone-shock pairings with either a 0.7-mA or 0.1-mA shock. Tone-evoked freezing was observed only with the higher shock intensity, indicating that the 0.1-mA shock corresponded to a sub-conditioning procedure. All conditioned rats underwent fear extinction with 20 tone-alone trials. When retrained with the sub-conditioning procedure, they displayed again tone-evoked freezing, except when the initial tone was unpaired or a new tone was paired with the 0.1-mA shock, demonstrating fear return rather than fear learning potentiation. We also found that HPC and mPFC tetanic stimulations, applied 24h after the sub-conditioning procedure, similarly reduced this fear return. However, mPFC inactivation abolished temporary HPC tetanus effect, whereas HPC inactivation did not interfere with mPFC tetanus effect. These data confirm our previous findings and reveal the nature of HPC-mPFC interactions in post-extinction modulation of conditioned fear.     

班级环境与青少年抑郁的关系：核心自我评价的中介与调节作用

通过整群抽样的方法抽取了1404名中学生,对其施测核心自我评价量表,我的班级问卷和抑郁问卷,应用无约束结构方程模型技术和结构方程中介效应检验技术,分别考察了核心自我评价在班级环境与抑郁关系间的调节与中介作用。结果表明：（1）核心自我评价对班级环境中的师生关系、同学关系、竞争三者和抑郁之间的关系起着调节作用,但结构模型的拟合指数不佳;（2）核心自我评价在班级环境与青少年抑郁间起着中介作用,其中核心自我评价在竞争与抑郁间关系起着完全中介作用。     

Surprise-induced blindness: a stimulus-driven attentional limit to conscious perception

The cost of attending to a visual event can be the failure to consciously detect other events. This processing limitation is well illustrated by the attentional blink paradigm, in which searching for and attending to a target presented in a rapid serial visual presentation stream of distractors can impair one's ability to detect a second target presented soon thereafter. The attentional blink critically depends on 'top-down' attentional settings, for it does not occur if participants are asked to ignore the first target. Here we show that 'bottom-up' attention can also lead to a profound but ephemeral deficit in conscious perception: Presentation of a novel, unexpected, and task-irrelevant stimulus virtually abolishes conscious detection of a target presented within half a second after the 'Surprise' stimulus, but only for its earliest occurrences (generally 1 to 2 presentations). This powerful but short-lived deficit contrasts with a milder but more enduring form of attentional capture that accompanies singleton presentations in rapid serial visual presentations. We conclude that the capture of stimulus-driven attention alone can limit explicit perception.     

TOWARD A MENTALISTIC ACCOUNT OF EARLY PSYCHOLOGICAL REASONING

Recent investigations of early psychological understanding have revealed three key findings. First, young infants attribute goals and dispositions to any entity they perceive as an agent, whether human or non-human. Second, when interpreting an agent's actions in a scene, young infants take into account the agent's representation of the scene, even if this representation is less complete than their own. Third, at least by the second year of life, infants recognize that agents can hold false beliefs about a scene. Together, these findings support a system-based, mentalistic account of early psychological reasoning.     

脱域与重构:反思现代性的中国问题与哲学视域

在新全球化时代,中国的反思现代性出现了本土化的"脱域"与"重构"两大特征。所谓本土的"脱域",就是中国的现代性正处在一种"时空倒错"的格局中,原本在西方依次出场的前现代、现代与后现代,在新全球化语境中于中国共时出场或错序出场;所谓"重构",即与全球一系列后现代特征对接的中国现代化既不是经典现代性,也不是后现代,也不是西欧"新现代"或"反思的现代性"的跨界平移,而是立足中国本土的"新现代性",从而形成了具有本土风格的中国问题,需要我们以中国立场、全球视域来观察中国问题,建立中国新现代性理论。     

三教同源——在武夷山"道、儒、释三教论坛"上的讲话

各位朋友:中华民族道、儒、释三大文化体系,对人类社会发展进步都起到了一定的作用,但唯独道文化早,迄今已有五千多年的历史。道文化胚胎于黄帝,集成于老子。老子降生于春秋时代,也就     

Protocoles contre la douleur : la loi nous aide-t-elle ?

At heart of all health professionals’concerns lays the battle against pain. The creation of protocols in the midst of health institutions contributes largely to this battle. Nevertheless, the question arises whether the law ensures the protection of all attendants during the implementation of these protocols.     

A sense of awe: On the differences between Confucian thought and Christianity

The fundamental importance of reverence is recognized by all major world cultures. Confucianism’s account of “The three things of which the sage is in awe” is seen in Chinese culture through the value placed on reverence. “The three things of which the sage is in awe” both manifests itself as an approach to value and is also an expression of practical ethical guidance. The essential aspect of reverence is a sincere and ethical outlook; accordingly it is a part of virtue ethics. In this kind of virtue ethics, ethical practice accords with self-conscious conduct that is guided by a sense of reverence, and this forms the guiding thought of Confucianism. From a comparative cultural perspective, the Confucian sense of reverence founded upon ethical self-awareness and Christian sense of reverence founded on divine worship are different. However, both take reverence to be the root of culture, thus proving that reverence is an element that none of the world’s major cultures can be without. In the early modern period, a sense of reverence was seen something enchanted and harmful to the rational progress of civilization. However, the contemporary reenchantment movements in some ways call up a return to such reverence.