This study investigated the effect of isoflavone aglycone (IA) on the learning and memory performance of senescence-accelerated mice, and explored its neural protective mechanism. Results showed that SAM-P/8 senescence-accelerated mice treated with IA performed significantly better in the Y-maze cognitive test than the no treatment control (P<0.05). The cortex AchE activity, serum SOD and GSH-Px activities were notably higher (P<0.05). MDA concentration and the β-secretase activity in the hippocampal tissue were both lower (P<0.05). Additionally, the number of hippocampal neurons was increased and cell morphology was significantly improved. Data suggested that IA could indirectly increase concentration of the cholinergic neural transmitter Ach through regulation of AchE, therefore improving the central cholinergic function and enhancing the learning and memory ability. By reducing the β-secretase activity, IA could decrease the formation and deposition of insoluble Adebris, relieve the resulted toxicity and damage to neurons, and thereby effectively protect the nervous system. 相似文献
It is hypothesized that playfulness in adults is positively associated with relationship satisfaction and that specific types of attachment and love are related with this trait. Findings, based on two samples of adults that are currently in a relationship (N?=?161 and 598), show that playfulness is positively associated with relationship satisfaction—albeit low in effect size. Playfulness shares about 17 % overlapping variance with different types of love and attachment; particularly, Seduction, low Market Orientation, Attachment, and Love were predictive for playfulness. While gender differences only played a minor role it was shown that playfulness mediates about 5.7 % of the gender differences in the inclination to Sexuality. Overall, findings are in the expected direction. The discussion highlights the importance of considering multidimensional measures for playfulness and satisfaction and gives future research directions. 相似文献
In this research we examine the effect of adding a food topping to the base food on consumers' calorie estimation and consumption of the augmented food (base food plus topping). We show that consumers underestimate the calorie content of augmented food with an unhealthy base, especially when the topping is healthy. However, consumers are less likely to underestimate the calorie content of augmented food with a healthy base, regardless of whether the topping is healthy or unhealthy. Further, we show that adding a healthy topping to an unhealthy base makes consumers not only underestimate the calorie content but also eat more of the augmented food. 相似文献
This article aims to investigate the training effect of working memory in older adults. A total of 43 older adults ranging in age from 75 to 95 were recruited to participate in the study. A battery of tests regarding central executive function, working memory, and primary mental ability were administered in the pretest phase. A total of 22 of the older participants were randomly selected as the intervention group. Thirteen days after the pretest, the same tests were administered to all of the participants. The results showed that (1) the differences in the pretest and posttest gains in the task-switching tests were not significant between the intervention group and the control group; (2) the performance of the intervention group on the operation working memory span test and the graphical reasoning test showed a significant improvement after the intervention compared with the control group who did not receive the intervention. We can conclude that the working memory of old adults may be improved by an intervention targeting the central executive system. However, this possibility needs further investigation. 相似文献
In previous studies, a physical response-distance effect was found in the two-choice Stroop color-identification task, with the Stroop effect being larger when the two response keys were physically close together than when they were far apart. In the present study, we found a conceptual response-distance effect, with the Stroop effect being larger when the response keys were conceptually close (labeled as “5” and “6”) than when they were conceptually far (labeled as “1” and “9”). Moreover, a response-distance effect due to pure physical distance was not evident; rather, the effect was found only when additional keys were placed between the two far response keys. These results are in agreement with a view that response keys are coded as action goals, with farther conceptual distance and additional keys helping distinguish the action goals. The results are difficult to reconcile with accounts that place emphasis on the physical separation of the effectors or their inanimate extensions. 相似文献
It has become increasingly common for young children to be taken care of by multiple caregivers in China after the socio-economic reforms. Complex migration patterns and high female labour force participation have led to children receiving care from various individuals in different contexts. However, little is known about how childcare arrangements are associated with child health well-being. This study examines various early childhood caregivers and their influences on children’s physical health in China. Using data from the China Health and Nutrition Survey (CHNS 1991–2011) with 3,470 children aged 2 to 6, we first identified different types of childcare arrangements in and outside of the household based on who provides the care, where they provide the care, and the intensity of the care. Then we examined the relationship between various childcare arrangements and health outcomes for children. Overall, household members undertook early childhood care tasks in China, with an increase in grandparents as primary caregivers between 1991 and 2011. The proportion of children receiving formal childcare fluctuated around 20% during this period. The findings suggest that: 1) primary caregiver in the household other than parents is not associated with undesirable physical health outcomes; 2) formal childcare outside the household is associated with higher height and lower BMI scores; 3) primary caregivers in the household, particular grandparents, moderate the association between childcare arrangements outside the household and children’s health outcomes. It yields an implication that early childhood care policies incorporating multiple caregivers would benefit children’s well-being in China.