Neurobiological Markers of Illness Onset in Psychosis and Schizophrenia: The Search for a Moving Target

In this review, we describe neuropsychological and brain imaging findings in the early stages of psychosis and schizophrenia. We focus on recent clinical high-risk studies and consider whether the evidence supports these as ‘endophenotypes’ of a vulnerability to the illness or as ‘biomarkers’ of illness onset and transition. The findings suggest that there are a number of processes at psychosis onset that may represent biomarkers of incipient illness. These neurobiological indices particularly implicate the integrity of frontal and temporal cortices, which may or may not be related to the genetics of psychosis (i.e. potential ‘endophenotypes’). However, these brain regions are dynamically changing during normal maturation, meaning that any putative neurobiological markers identified at the earliest stages of illness may be relatively unstable. We suggest that, while such measures may be readily identified as potential neurobiological markers of established illness, they are inconsistent at (or around) the time of illness onset when assessed cross-sectionally. Instead, identification of more valid risk markers may require longitudinal assessment to ascertain normal or abnormal trajectories of neurodevelopment. Accordingly, we assert that the current conceptualisations of potential biomarkers and/or ‘endophenotypes’ for schizophrenia may need to be reconsidered in the context of normal and abnormal brain maturational processes at the time of onset of psychotic disorders.     

集权的道德哲学反思

集权是以功利目的论为理论根基,以"例外特质"为道德心理基础,以独断的道德相对论和独断的道德一元论的不良混合为道德特征,以暴力和强制为后盾的不道德的特殊权利.集权践踏人权、违背人性,不配享有权利之名,因而是必须祛除的对象.     

Both exogenous and endogenous target salience manipulations support resource depletion accounts of the attentional blink: A reply to Olivers, Spalek, Kawahara, and Di Lollo (2009)

Input control theories of the attentional blink (AB) suggest that this deficit results from impaired attentional selection caused by the post-Target 1 (T1) distractor (Di Lollo, Kawahara, Ghorashi, & Enns, 2005; Olivers, van der Stigchel, & Hulleman, 2007). Accordingly, these theories predict that there should be no AB when no distractors intervene between the targets. Contrary to these hypotheses, Dux, Asplund, and Marois (2008) observed an AB (T3 deficit) when three targets, from the same attentional set, were presented successively in a rapid stream of distractors, if subjects increased the resources they devoted to T1 processing. This result is consistent with resource depletion accounts of the AB. However, Olivers, Spalek, Kawahara, and Di Lollo (2009) argue that Dux et al.’s results can be better explained by the relationship between T1 and T2, and by target discriminability effects, rather than by the relationship between T1 and T3. Here, we find that manipulating the resources subjects devote to T1, either exogenously (target perceptual salience) or endogenously (target task relevance), affects T3 performance, even when T2 and target discriminability differences are controlled for. These results support Dux et al.’s conclusion that T1 resource depletion underlies the AB.     

How representationalism can account for the phenomenal significance of illumination

In this paper, I defend a representationalist account of the phenomenal character of color experiences. Representationalism, the thesis that phenomenal character supervenes on a certain kind of representational content, so-called phenomenal content, has been developed primarily in two different ways, as Russellian and Fregean representationalism. While the proponents of Russellian and Fregean representationalism differ with respect to what they take the contents of color experiences to be, they typically agree that colors are exhaustively characterized by the three dimensions of the color solid: hue, saturation, and lightness. I argue that a viable version of representationalism needs to renounce this restriction to three dimensions and consider illumination to be a genuine phenomenal dimension of color. My argument for this thesis falls into two parts. I first consider the phenomenon of color constancy in order to show that neither Russellian nor Fregean representationalism can do justice to the phenomenal significance of local illumination. I subsequently formulate a version of representationalism that accounts for illumination by taking it as a phenomenal dimension of color.     

句子语境中汉语词汇歧义消解的ERP研究

采用ERP方法,考察了汉语词汇歧义消解中句子语境作用的时间进程及大脑活动。目标词与句子语境存在一致、不一致、无关控制等3种关系。结果显示:(1)一致与不一致条件下N400的平均波幅均显著低于无关控制条件;(2)SOA为200毫秒时产生的N400平均波幅的幅度显著高于SOA为1000毫秒的条件;(3)N400的平均波幅及潜伏期均表现出左半球显著高于右半球的特点。实验结果支持词汇歧义消解的模块化观点,体现了大脑两半球语言功能的不对称性。     

Self‐ambivalence and reactions to success versus failure

People differ in the extent to which their self‐evaluations fluctuate in response to positive and negative events. This research tests whether self‐ambivalence predicts this self‐evaluative reactivity. Participants first completed measures of self‐ambivalence and baseline self‐esteem. Next, they were induced a success or failure experience in a cognitive task and finally rated their cognitive self‐evaluations (task‐specific ability, state self‐esteem) and affective reactions (self‐feelings, mood). Self‐ambivalence was associated with stronger effects of the success/failure manipulation on cognitive self‐evaluations but not on affective reactions, with baseline self‐esteem controlled. Possible underlying mechanisms are discussed. Copyright © 2006 John Wiley & Sons, Ltd.     

Being Admired or Being Liked: Classroom Social Status and Depressive Problems in Early Adolescent Girls and Boys

This study investigates associations between depressive problems and classroom social status in a large population cohort of Dutch early adolescents (N = 1046, age 13.52 +/- 0.51, 52.4% girls). Depressive problems were assessed by parent and self-reports and classroom status by peer nominations. We assessed peer status with respect to both achievement-related (being a good learner, being good at sports, being good-looking) and affection-related (being liked, being disliked, being best friend) areas. In boys, depressive problems were most strongly associated with not being good at sports, while in girls the association was strongest for not being liked. The risk of a low status in one area could largely be compensated by a high status in another area.     

领导-部属交换（LMX）的回顾与展望

领导-部属交换理论从领导和部属的对偶关系中考察领导行为及其对下属的绩效、组织承诺等结果变量的影响。文章回顾了领导-部属交换的文献,对于它的概念、理论基础、结构、测量工具等进行了综合介绍,对不同测量工具的各自的特点以及它们之间的关系做了分析,接着总结了影响领导-部属关系的影响因素和结果变量以及与变革型领导的关系,最后提出未来研究应该加强从领导部属交换的发展阶段以及从部属或领导的角度来分析领导-部属交换理论     

M(u)ler-Lyer错觉作用机制的眼动研究

使用美国应用科学实验室生产的504型眼动仪,以错觉量和眼动特征为指标,考察了Muller-Lyer(ML)错觉的产生及其作用过程.结果表明:(1)在ML错觉中,较长箭杆促进长度的准确判断,较长箭翼干扰长度的准确判断.减弱ML图形的总长度线索有助于降低错觉量;(3)箭杆与箭翼的交互作用对注视时间产生显著影响;(3)被试通过整合两条矛盾的线索进行长度判断,实验结果支持矛盾线索理论.     

The influence of height and key on the perceptual similarity of transposed melodies

In two experiments, the perceptual similarity between a strong tonal melody and various transpositions was investigated using a paradigm in which listeners compared the perceptual similarity of a melody and its transposition with that of the same melody and another transposition. The paradigm has the advantage that it provides a direct judgment regarding the similarity of transposed melodies. The experimental results indicate that the perceptual similarity of a strong tonal melody and its transposition is mainly determined by two factors: (1) the distance on the height dimension between the original melody and its transposition (pitch distance), and (2) the distance between keys as inferred from the circle of fifths (key distance). The major part of the variance is explained by the factor pitch distance, whereas key distance explains only a small part.