Differential indications for desipramine--results of a controlled multiclinical study]

The antidepressants desipramine and imipramine were compared within the framework of a multiclinical study performed under the conditions of a controlled clinical experiment. There has been found a time-different remission of affective symptoms, which was not detectable for the inhibition of drive. The tachythymoleptic action of desipramine is discussed with reference to these results. Evaluation of the possibility of controlling affects shows different ranges of activity of desipramine and imipramine, with desipramine influencing especially negative psychoenergetic symptoms in the area of drives and emotions and imipramine, restrictive symptoms in addition to differential phenomena of the psychomotor expression.     

The subjective vertical under ‘dry’ and ‘wet’ conditions at clockwise and counterclockwise changed positions and the effect of a parallel-lined background field

Summary The dependence of the subjective vertical (SV, the angle between a subjective vertical line and body median plane) on the gravity vertical (body tilt position, angle ) and on the optical vertical (i.e., a field of parallel lines seen as background to the line to be adjusted) was investigated. The SV was measured under dry and wet conditions at different degrees of body tilt attained in either clockwise (CW) or counterclockwise (CCW) progression.The measured difference in between field-of-lines left and right of the line is smallest at the upright position (=O°) and largest at =150°/165°. All body positions show a -difference between CW and CCW attainment (hysteresis), this too being least at upright and greatest at inverted body positions.These results, and changes of with test time, are discussed relative to the hypothesis that efficiency of the statolith organs decreases with body tilt increase, favouring increase of interference of somatoreceptors and the optical reference.     

The influence of verbal specifications on ratings of relative properties of pictures

Summary Sixty subjects were shown pictures each containing two objects (A and B). The objects were unobtrusive with respect to relative properties such as long — short, big — small, etc. The pictures were preceded by sentences referring either to objects A and B or only to object A. Object A was dimensionally specified: The same object was called, e.g., long for one and short for a different subject. Ratings during a later test (without presentation of the pictures) revealed that not only were objects A remembered according to the verbal specification provided during the presentation but ratings of objects B also changed in line with the specification of A. This was true even when object B had not been mentioned verbally during the presentation. In this way, verbal specifications had an effect beyond the referential bond. It is concluded that models based on the assumption that the semantic interpretation of an event depends on the application of syntactic rules — rules indicating, e.g., to which object an adjective refers — lack an important clue.     

The treatment of epilepsies with Convulsofin

The testing of Convulsofin carried out in 220 patients at 14 clinics over a period of six months confirms the international experience gained with valproic acid and sodium valproinate. The main field of application of Convulsofin according to the experience gained will again be the treatment of fits in generalised primary epilepsy for which it permits to carry out a monotherapy to a remarkable extent. The favourable effect of the preparation in photosensitivity could be confirmed. Also in generalised secondary epilepsy and in fits of partial epilepsy. Convulsofin is partly effective, so that it can recommended as a co-medication in the treatment of therapy-resistant forms of these epilepsies which are difficult to treat. Decrease in thrombocytes, transient increase in serum transaminases, gastrointestinal disorders, loss of hair and undesired increases in body-weight were the more frequently occurring side-effects.     

Some theory and results for metrics for bounded response scales

In an earlier note, a new metric for bounded response scales (MBR) was introduced which resembles the city-block metric but is bounded above. It was suggested the MBR may be more appropriate than minkowski metrics for data obtained with bounded response scales. In this article, some formal properties of the MBR are investigated and it is shown that it is indeed a metric. Empirical predictions are then derived from the MBR and contrasted with those of a “monotonicity hypothesis,” which holds that dissimilarity judgements tend to be biased towards overestimation of larger distances, and with the predictions of the minkowski metrics, which imply additivity of collinear segments. Some empirical results are presented which contradict the monotonicity hypothesis and the minkowski metrics, and favor the MBR. Finally, the logic used to motivate the MBR is invoked to define a subadditive concatenation for bounded norms in the one-dimensional case, which may be useful in psychophysical work where the upper bounds are often real, rather than due to the response scale. This concatenation predicts understimation for doubling and overestimation for halving and middling tasks.     

Glutamate as a transmitter in the CNS and its presumed significance in the pathogenesis of cerebral seizure forms--recent aspects

Glutamate is believed to be quantitatively the most outstanding of the excitatory transmitters in the CNS. Certain conformationally related analogues, e. g. kainate, N-methyl-D-aspartate, ibotenate, and homocysteate, act as glutamate agonists. The local or systemic administration of these "excitotoxic" compounds induces epileptiform activity pointing out new and deeper insights into the epileptic process. Additionally, the glutamate transmitter hypothesis is expected to give a chance of a causal comprehension for choreatic processes as well as for the mode of action of anticonvulsant and antispastic agents.     

The sociodynamogram--a contribution to the objectivization of group process

Two simple sociometric techniques for practical use are described which are derived from the data given in the sociogram. Compared with the conventional sociogram, the group rank score we use everyday therapy has the advantage that it can be published. It permits members of the group to better identify the social situations which cause specific psychic impulses. The sociogram is reserved for the therapist. In our opinion the sociodynamogram has certain advantages over both methods because it provides an insight into spheres which are inaccessible in the sociogram and group rank score.     

Determinants of pride and shame: outcome, expected success and attribution

In two experiments we investigated the relationship between subjective probability of success and pride and shame. According to Atkinson (1957), pride (the incentive of success) is an inverse linear function of the probability of success, shame (the incentive of failure) being a negative linear function. Attribution theory predicts an inverse U-shaped relationship between subjective probability of success and pride and shame. The results presented here are at variance with both theories: Pride and shame do not vary with subjective probability of success. However, pride and shame are systematically correlated with internal attributions of action outcome.