排序方式: 共有15条查询结果,搜索用时 0 毫秒
11.
Peter D. Patrick Ph.D. Reinaldo B. Oriá Ph.D. Vandana Madhavan M.D. Relana C. Pinkerton Ph.D. Breyette Lorntz Ph.D. Aldo A. M. Lima M.D. Ph.D. 《Child neuropsychology》2013,19(3):233-244
The effects of heavy burdens of diarrhea in the first 2 years of life on specific executive control function like verbal fluency are not well understood. In previous studies, we have shown associations of early childhood diarrhea (ECD) with nonverbal intelligence and school functioning. Therefore, we postulated that ECD might affect early neuropsychological development leading to long-term deficits in normal cognitive development. Based on our extensive 14-year prospective cohort studies of early childhood diarrheal illnesses in a Brazilian shantytown community, we examined ECD correlations between specific impairments of higher mental function and executive skills in shantytown children 5–10 years later (now at 6–12) years of age. Specifically we examined whether heavy diarrheal illnesses correlate with reduced performance on selected tests of executive function. Our study, for the first time, suggests a disproportional impairment in semantic but not phonetic fluency in a subset of children with heavy burdens of diarrhea in their first 2 years of life even when controlling for maternal education, breastfeeding, and child schooling. Similar semantic decrements have been associated with impaired recovery from brain injury. These exploratory studies suggest the importance of verbal fluency tests to assess executive functioning in children challenged by poor nutrition and diarrhea in early life. In addition, our unique findings show the potential influences of early childhood diarrhea on language development that is so critical to productive adulthood and potentially set a foundation for new neuropsychological approaches, which assess early burdens of enteric illnesses on childhood development. 相似文献
12.
For the past 10 years, qualitative research methodology has become more visible in counseling studies. Results from a content analysis of articles published between 1997 and 2002 in 4 professional journals in the field (Counseling and Values, Journal of Counseling & Development, Professional School Counseling, and The Counseling Psychologist) reveal that qualitative research represents 1/6 of all the articles published. Research trends in target publications are identified and suggestions for the development of the field regarding qualitative research are presented. 相似文献
13.
Martina Blank Laura D. Guerim Reinaldo F. Cordeiro Monica R.M. Vianna 《Neurobiology of learning and memory》2009,92(4):529-534
The behavioral tasks aiming to evaluate learning and memory mechanisms currently available to zebrafish (Danio rerio) involve long training sessions frequently along multiple days and are based on shuttle box or active-avoidance protocols, preventing a detailed analysis of cellular and molecular time-dependent processes involved in memory acquisition and consolidation. In order to explore zebrafish’s potential contribution to the characterization of the molecular machinery underlying learning and memory rapidly acquired and reliable paradigms are necessary. In this study we present a rapid and effective learning protocol in a single-trial inhibitory avoidance in zebrafish. In a simple apparatus, adult animals learned to refrain from swimming from a white into a dark compartment in order to avoid an electric shock during a single-trial training session that lasted less than 2 min. The resulting memory is robust, long-lasting and sensitive to NMDA-receptor antagonist MK-801 given in the tank water immediately after training. Experiments aiming to further characterize the events underlying memory formation, retrieval or extinction or those looking for cognitive profiling of mutants, neurotoxicological studies and disease models may benefit from this task, and together with complementary strategies available for zebrafish may significantly improve our current knowledge on learning and memory mechanisms. 相似文献
14.
15.