Stigma, Culture, and HIV and AIDS in the Western Cape, South Africa: An Application of the PEN-3 Cultural Model for Community-Based Research

HIV- and AIDS-related stigma has been reported to be a major factor contributing to the spread of HIV. In this study, the authors explore the meaning of stigma and its impact on HIV and AIDS in South African families and health care centers. They conducted focus group and key informant interviews among African and Colored populations in Khayelitsha, Gugulethu, and Mitchell's Plain in the Western Cape province. The audio-recorded interviews were transcribed and coded using NVivo. Using the PEN-3 cultural model, the authors analyzed results showing that participants' shared experiences ranged from positive/nonstigmatizing, to existential/unique to the contexts, to negative/stigmatizing. Families and health care centers were found to have both positive nonstigmatizing values and negative stigmatizing characteristics in addressing HIV/AIDS-related stigma. The authors conclude that a culture-centered analysis, relative to identity, is central to understanding the nature and contexts of HIV/AIDS-related stigma in South Africa.     

Target-biting behavior of individually and group-housed mice and rats

The effects of housing conditions (individual or grouped) on the biting of an inanimate target by confined male mice and rats were measured. It was observed that, for both mice and rats, individual housing markedly increased the number of target bites per session. These results indicate that the target-biting paradigm is sensitive to those factors responsible for the increase in fighting behavior following individual housing.     

Stress and cardiac beta adrenoceptors

Most modern theories about stress recognize that although stress is not a disease, it may be the trigger for the majority of diseases when allostatic overload has been generated. During stress, the glucocorticoids and catecholamines play a key role in the regulation of physiological parameters and homeostasis during stress. In the heart, positive chronotropic, inotropic, and lusitropic responses to catecholamines are mediated by various subtypes of adrenergic receptors (beta-ARs), mainly beta1- and beta2-adrenergic receptors. beta-ARs also control cardiomyocyte growth and death, thus contributing to cardiac remodelling. The structural basis of each beta-AR subtype, as well as their signalling pathways, and adaptive responses to stress are discussed. The participation of beta3- and putative beta4-ARs in the control of cardiac function is also discussed, with emphasis on low affinity beta-AR isoforms and the role they play in the response to the catecholamines under stress. The changes in beta-AR signalling under pathogenic conditions as well as under stress are reviewed.     

Relational information processing of novel unrelated actions by infants

Declarative memory in infants is often assessed via deferred imitation. Not much is known about the information processing basis of the memory effect found in these experiments. While in the typical deferred imitation study the order of actions remains the same during demonstration and retrieval, in two experiments with n=30 respective n=25, 10- and 11-month-old infants, the order of novel unrelated actions in demonstration and retrieval was varied (same, reversed, mixed). This allowed a separation of item-specific from item-relational information processing. In both experiments best memory performance was found when the order of target actions remained the same during encoding and recall, demonstrating that infants seem to rely on item-specific as well as item-relational information which has to be ad hoc constructed while encoding.     

Effects of repetition and response deadline on item recognition in young and older adults

In the present study, we examined the joint effects of aging, repetition, and response deadline in a plurality discrimination task. Young and older adults studied lists of unrelated singular and plural nouns, with half presented once (weak items) and half presented five times (strong items). Test lists contained old (same) nouns, plurality-reversed nouns (changed lures), and unstudied nouns (new lures), and the participants were asked to respond old only to same items. In Experiment 1, the participants were tested with both short and long deadlines. In Experiment 2, the tests were unpaced. In both experiments, repetition increased hit rates for young and older adults. Young adults tested with a long deadline or no deadline showed invariant (Experiment 1) or reduced (Experiment 2) false alarms to changed lures when the nouns were studied more often. Young adults tested with a short deadline and older adults tested with both long and short deadlines had increased false alarm rates for strong changed lures; without time pressure to respond, older adults did not have a significant increase in false alarms for changed lures. Implications of these results for theories of cognitive aging are explored.     

C.S. Peirce on Mathematical Practice: Objectivity and the Community of Inquirers

Topoi - What understanding of mathematical objectivity is promoted by Peirce’s pragmatism? Can Peirce’s theory help us to further comprehend the role of intersubjectivity in...     

Genetic counseling for the next 25 years: Models for the future

Currently, two trends pose particular challenges for genetic counseling: (1) spin offs from the Human Genome Project leading to new diagnostic genetic tests far in advance of any cures; and (2) an increasing and diversified client population. These trends will lead to changes in both genetic service delivery systems and the development of alternative models of the genetic counseling process itself. Two models that could be adapted for genetic counseling are: the mutual participation model and the life history narrative model. Technological advances present ethical dilemmas and raise many questions. Already, improved detection of genes for predisposing conditions has entered clinical medicine requiring renewed ethical appraisals of genetic testing. Integration of genetic counseling (and required pre-screening education) into primary care settings involves time constraints and the involvement of health care personnel with less training in genetics. Alternative approaches are beginning to be discussed. Innovative genetic counselors with expanded visions of counseling goals and practices will play an increasingly important role in the future of genetic counseling.