Oral administration of guanosine impairs inhibitory avoidance performance in rats and mice

Extracellular guanine-based purines, mainly the nucleoside guanosine, have recently been shown to exert neuroprotective effects, which seem to be related to antagonism of the glutamatergic system. In this study, we investigated the effects of acute oral administration of guanosine on inhibitory avoidance task in rats and mice. We also studied its effects on locomotor activity, anxiety-related behaviors and mechanisms of action involving the purinergic system. Guanosine (2.0 and 7.5mg/kg, per os), administered 75min pretraining, dose-dependently impaired retention of the inhibitory avoidance task in rats and mice, an effect not prevented by the adenosine receptor antagonist caffeine. Guanosine presented no effects on locomotor activity and anxiety-related behaviors. This amnesic effect of guanosine may be compatible with inhibition of glutamatergic system and seems to be not mediated by adenosine.     

Sensitivity to stimulus similarity is associated with greater sustained attention ability

Sustained attention is critical for tasks where perceptual information must be continuously processed, like reading or driving; however, the cognitive processes underlying sustained attention remain incompletely characterized. In the experiments that follow, we explore the relationship between sustaining attention and the contents and maintenance of task-relevant features in an attentional template. Specifically, we administered the gradual onset continuous performance task (gradCPT), a sensitive measure of sustained attention, to a large web-based sample (N>20,000) and a smaller laboratory sample for validation and extension. The gradCPT requires participants to respond to most stimuli (city scenes – 90 %) and withhold to rare target images (mountain scenes – 10 %). By using stimulus similarity to probe the representational content of task-relevant features—assuming either exemplar- or category-based feature matching—we predicted that RTs for city stimuli that were more “mountain-like” would be slower and “city-like” mountain stimuli would elicit more erroneous presses. We found that exemplar-based target-nontarget (T-N) similarity predicted both RTs and erroneous button presses, suggesting a stimulus-specific feature matching process was adopted. Importantly, individual differences in the degree of sensitivity to these similarity measures correlated with conventional measures of attentional ability on the gradCPT as well as another CPT that is perceptually less demanding. In other words, individuals with greater sustained attention ability (assessed by two tasks) were more likely to be influenced by stimulus similarity on the gradCPT. These results suggest that sustained attention facilitates the construction and maintenance of an attentional template that is optimal for a given task.     

Validation of the German Version of the Sexual Self-Esteem Inventory for Women and its Application in a Sample of Sexually and Physically Abused Women

Results regarding the association between global self-esteem and sexual behavior suggest the importance of a domain-specific construct—so-called sexual self-esteem (SSE). Prior studies suggested that SSE is malleable and found a negative impact of sexual abuse on SSE. In the present study, the German translation of the Sexual Self-Esteem Inventory-Short Form (SSEI-SF) by Zeanah and Schwarz (1996) was validated via an online survey with 557 women and then investigated in a clinical sample of women suffering from PTSD following sexual and physical abuse compared with healthy controls (n = 130). We examined differences in SSE depending on the type of abuse. Confirmatory factor analysis revealed adequate model fit, with acceptable-to-excellent reliability (α = .78–.94) and sound convergent and discriminant validity. As expected, SSEI-SF scores were significantly lower in the clinical sample than those in the healthy control group. Within the clinical sample, there were no significant differences in SSE between clients who had experienced sexual abuse and those who had experienced physical abuse, but a history of sexual abuse was significantly linked to lower SSE and SSE was related to both sexual behavior and sexual satisfaction. In conclusion, our study supports the validity and applicability of the German version of the SSEI-SF. Results regarding the differences in SSE between survivors of abuse and healthy controls contribute to the further understanding of female sexuality and have implications for treatment.     

Alcohol Counseling in Hospital Trauma: Examining Two Brief Interventions

Hospital trauma centers intervene with patients who incur alcohol‐related injuries. This prospective study, using professional counselors and trainees, investigated brief counseling interventions (BCIs). Participants were randomized to either a conventional BCI examining quantity and frequency of drinks or a personalized BCI exploring overintoxication. No statistically significant difference between risky drinkers randomized to either intervention in a hospital trauma center was observed. Findings indicate that a personalized BCI may be an alternative to a quantitative BCI in reducing risky alcohol consumption.     

Addiction Topics in Counselor Educator Professional Development: A Content Analysis

Counselor educators prepare master's‐level counselors‐in‐training on addiction topics. This content analysis examined the frequency and types of addiction topics for counselor educator continuing education. The results revealed limited attention to addiction topics within professional literature and conference presentations.     

Psychological Treatments for Symptoms of Posttraumatic Stress Disorder in Children,Adolescents, and Young Adults: A Meta-Analysis

Meta-analyses of the treatment of posttraumatic stress disorder (PTSD) in childhood and adolescence are restricted to specific trauma, selected interventions, and methodologically rigorous studies. This large meta-analysis quantifies the effects of psychological treatments for PTSD symptoms in children and adolescents. An extensive literature search yielded a total of 13,040 articles; 135 studies with 150 treatment conditions (N = 9562 participants) met the inclusion criteria (psychological interventions with children and/or adolescents with PTSD symptoms that report quantitative measures of symptom change). The mean effect sizes (ESs) for PTSD symptoms ranged from large to small, depending on the control condition. Cognitive behavioral therapy (CBT) yielded the highest ESs. Age and caretaker involvement were identified as moderators. CBT, especially when conducted in individual treatment with the inclusion of parents, is a highly effective treatment for trauma symptoms. Psychological treatments need to be modified to address younger patients’ specific needs.     

Similar stimulus features control visual classification in orangutans and rhesus monkeys

Many species classify images according to visual attributes. In pigeons, local features may disproportionately control classification, whereas in primates global features may exert greater control. In the absence of explicitly comparative studies, in which different species are tested with the same stimuli under similar conditions, it is not possible to determine how much of the variation in the control of classification is due to species differences and how much is due to differences in the stimuli, training, or testing conditions. We tested rhesus monkeys (Macaca mulatta) and orangutans (Pongo pygmaeus and Pongo abelii) in identical tests in which images were modified to determine which stimulus features controlled classification. Monkeys and orangutans were trained to classify full color images of birds, fish, flowers, and people; they were later given generalization tests in which images were novel, black and white, black and white line drawings, or scrambled. Classification in these primate species was controlled by multiple stimulus attributes, both global and local, and the species behaved similarly.