Tolerance to drug-induced (poly I:C) natural killer cell activation: congruence with a Pavlovian conditioning model

Two experiments were conducted to assess the role of conditioning factors on the tolerance of drug-induced natural killer (NK) cell activity. A protocol in which mice were given four weekly injections of the immunostimulatory synthetic polynucleotide (poly I:C) paired with a complex environmental stimulus produced a reliable tolerance effect. The sensitivity of the observed tolerance to known decremental conditioning procedures--extinction (Experiment 1) and preexposure to the conditioning stimulus (latent inhibition, Experiment 2)--was investigated. The results indicated that posttreatment exposure to drug-signaling cues (i.e., extinction) significantly reversed tolerance such that NK cell activity was at a level comparable to that for controls receiving the drug for the first time (Experiment 1). In a similar fashion, pretreatment exposure to the drug-signaling cues (CS preexposure) inhibited the development of tolerance (Experiment 2). These results provide initial evidence that nonpharmacological manipulations of drug-signaling environmental cues can affect tolerance to the immunostimulatory effect of poly I:C, as would be expected with a conditioning analysis of such tolerance.     

The relations between emotional understanding,intellectual functioning,and disruptive behavior problems in elementary-school-aged children

This study examined individual differences in children's emotional understanding and behavioral adjustment. Participants included 220 first- and secondgrade children (75% regular education, 25% special education) who were individually interviewed using the Kusche Affective Interview—Revised. Dependent measures of emotional understanding and experience included the ability to provide personal examples of 10 different emotions and the cues used for recognition of five emotions in oneself and other persons. Children were also administered the WISC-R Vocabulary, Block Design, and Coding subtests. One parent independently completed an Achenbach Child Behavior Checklist for each child. Results indicated that children who were rated as higher in behavior problems showed deficits in emotional understanding. Intellectual functioning was negatively associated with behavior problems and attenuated the effects of behavior problems on emotional understanding. Implications of the current findings for prevention and treatment programs for children with behavior problems are discussed.This research was supported by Grant PHS RO1 MH42131 from the Prevention Branch, National Institute of Mental Health. The authors thank Lisa Anderson and Dawn Kresevich for their invaluable help with data collection; Bob Beilke for his assistance in the development of the KAI-R coding system; and the dedicated coders of the KAI-R for their careful work.     

A Two-Year Longitudinal Study of Neuropsychological and Cognitive Performance in Relation to Behavioral Problems and Competencies in Elementary School Children

Despite interest in early neuropsychological status as a possible contributor to children's behavioral development, prospective longitudinal investigations of neuropsychological measures in relation to later behavioral outcomes in childhood are few. A 2-year longitudinal study in a nonselected childhood sample is reported. The study tested the influence of early neuropsychological performance (verbal fluency, mental inhibitory control, and visual spatial ability) on later childhood behavioral problems and social competency. Regular education children (n = 235) were assessed at three time points 1 year apart. To control for autocorrelation of outcome measures, Time 1 behavior was partialed while testing the effects of Time 1 neuropsychological scores on Time 3 outcome. To control for autocorrelation of neuropsychological scores, Time 2 scores were partialed while testing the predictive effect of Time 1 scores on Time 3 outcome. Both sets of regression models suggested modest but statistically significant effects for inhibitory control and verbal fluency, but not IQ, reading, or visual spatial ability, on behavioral outcome. Study results are consistent with a modest causal effect of selected neuropsychological skills on later behavioral adjustment. The findings support theories that implicate subtle neuropsychological dysfunction in the development of behavioral problems in childhood.     

Finding everland: Flight fantasies and the desire to transcend mortality

Fantasies and dreams of flight are ubiquitous across cultures and throughout history and often linked to immortality. A perspective derived from terror management theory holds that flight fantasies are appealing because they suggest transcendence of the limitations of creatureliness and mortality. Five studies established the link between mortality concerns and flight fantasy. In Study 1, participants showed greater desire to fly after contemplating death compared to a control topic. In Study 2, participants showed greater desire to fly, but not to engage in other supernatural acts, after contemplating death compared to a control topic. In Studies 3 and 4, participants who engaged in flight fantasy did not subsequently demonstrate defensive reactions to a death reminder observed in nonflight conditions. Study 5 showed that flight fantasy, but not other pleasurable or empowering fantasies, decreased death thought accessibility after mortality salience, and this effect was uniquely mediated by a feeling of freedom from bodily limits.     

Heightened interpersonal security diminishes the monetary value of possessions

People may value their possessions, in part, because ownership of goods promotes feelings of security. If so, increasing their sense of security should reduce the value they place on possessions. In two studies we tested this prediction. In Study 1, participants who were assigned randomly to write about an instance of receiving social support placed less monetary value on a blanket they owned relative to participants who were assigned randomly to write about a pleasant restaurant experience. In Study 2, participants who were unobtrusively primed with security-related words placed less monetary value on a pen they just received relative to participants who were primed with positive or neutral words. Results suggest that enhancing interpersonal security reduces valuing possessions.     

The moderating role of executive functioning in older adults' responses to a reminder of mortality

In previous research, older adults responded to mortality salience (MS) with increased tolerance, whereas younger persons responded with increased punitiveness. One possible explanation for this is that many older adults adapt to challenges of later life, such as the prospect of mortality, by becoming more flexible. Recent studies suggest that positively oriented adaptation is more likely for older adults with high levels of executive functioning. Thus, we hypothesized that the better an older adult's executive functioning, the more likely MS would result in increased tolerance. Older and younger adults were randomly assigned to MS or control conditions, and then evaluated moral transgressors. As in previous research, younger adults were more punitive after reminders of mortality; executive functioning did not affect their responses. Among older adults, high functioning individuals responded to MS with increased tolerance rather than intolerance, whereas those low in functioning became more punitive.     

The measurement of executive function at age 5: psychometric properties and relationship to academic achievement

This study examined the psychometric properties and criterion validity of a newly developed battery of executive function (EF) tasks for use in early childhood. The battery was included in the Family Life Project (FLP), a prospective longitudinal study of families who were oversampled from low-income and African American families at the birth of a new child (N = 1,292). Ninety-nine percent (N = 1,036) of children who participated in the age 5 home visit completed 1 or more (M = 5.8, Mdn = 6) of the 6 EF tasks. Results indicated that tasks worked equally well for children residing in low-income and not low-income homes, that task scores were most informative about the ability level of children in the low-average range, that performance on EF tasks was best characterized by a single factor, and that individual differences on the EF battery were strongly related to a latent variable measuring overall academic achievement, as well as to individual standardized tests that measured phonological awareness, letter-word identification, and early math skills.