Deliberate Microbial Infection Research Reveals Limitations to Current Safety Protections of Healthy Human Subjects

Here we identify approximately 40,000 healthy human volunteers who were intentionally exposed to infectious pathogens in clinical research studies dating from late World War II to the early 2000s. Microbial challenge experiments continue today under contemporary human subject research requirements. In fact, we estimated 4,000 additional volunteers who were experimentally infected between 2010 and the present day. We examine the risks and benefits of these experiments and present areas for improvement in protections of participants with respect to safety. These are the absence of maximum limits to risk and the potential for institutional review boards to include questionable benefits to subjects and society when weighing the risks and benefits of research protocols. The lack of a duty of medical care by physician–investigators to research subjects is likewise of concern. The transparency of microbial challenge experiments and the safety concerns raised in this work may stimulate further dialogue on the risks to participants of human experimentation.     

Distance Learning: Empathy and Culture in Junot Diaz’s “Wildwood”

This essay discusses critical approaches to culture, difference, and empathy in health care education through a reading of Junot Diaz’s “Wildwood” chapter from the 2007 novel The Brief Wondrous Life of Oscar Wao. I begin with an analysis of the way that Diaz’s narrative invites readers to imagine and explore the experiences of others with subtlety and complexity. My reading of “Wildwood” illuminates its double-edged injunction to try to imagine another’s perspective while recognizing the limits to—or even the impossibility of—that exercise. I draw on post-colonial theory and feminist science studies to illuminate a text that is created and interpreted in a post-colonial context—the Dominican diaspora in the United States. The essay offers a model of historical and critical analysis that health care educators can use to frame the concept of empathy in the classroom and the clinic.     

A Multidimensional Scaling Analysis of Perceptions of Academic Dishonesty Among Fifth-Grade Students

A study was conducted to investigate the perceptions of academic dishonesty in fifth-grade students. Two methods were used to gather data: a sorting task, which was used to indirectly assess the students' perceptions, and a rating scale task, which was used to externally validate the results of the sorting task. Results of the multidimensional scaling analysis yielded two dimensions, the first being tests/homework and papers, and the second, more ambiguous appearing to differentiate based on seriousness.     

Spiritual Struggles and Mental Health: Exploring the Moderating Effects of Religious Identity

Although many studies have explored the salutary associations between multiple dimensions of religiousness and psychological well-being, a smaller body of work has focused on the links between spiritual struggles and negative mental health outcomes. Two types of spiritual struggles have received considerable attention in this literature: divine struggles, or troubled relationships with God, and struggles with belief, or religious doubts. Using data from a nationwide online survey of U.S. adults conducted in 2006, our study investigated links between these types of spiritual struggles and four aspects of psychopathology: depressed affect, anxiety, phobic anxiety, and somatization. In particular, we tested the hypothesis that these links vary according to religious identity, such that individuals who identify themselves as highly religious—and therefore are likely to be most invested in their roles as religious persons—experience the strongest negative effects of spiritual struggles, in comparison with persons who identify themselves as moderately religious, or not religious at all. Findings supported this overall hypothesis. The article concludes by noting several study limitations and identifying promising directions for further research.     

Postnatal mental health and mothers’ processing of infant emotion: an eye-tracking study

ABSTRACT

Background

Postnatal mental illnesses are associated with less maternal sensitivity. Differences in how mothers with and without mental illness process infant emotions could explain this. People with mental illness in non-perinatal populations show certain processing patterns when viewing emotional faces, but it is not clear whether these patterns are present in mothers.     

The Differential Effects of Negative Affectivity on Measures of Well-being versus Job Satisfaction and Organizational Commitment

This paper reports an empirical study of the self-reported psychological strain, ill-health, job satisfaction and organizational commitment of 2450 public sector employees located in Western Australia. The framework used to predict these variables is a demands, supports-constraints framework. The key theoretical issue explored is the differential roles of negative affectivity in predicting the outcomes from this framework. Four different pathways are explored which are taken from Moyle ( Journal of Organizational Behaviour , 16 (1995), 647-668). Multiple regression methods are used to control for negative affectivity and other effects such as curvilinear relationships. The results show that negative affectivity has a variety of effects on both health and job attitude variables but the effects are much larger for the health variables. The conclusion recommends that, in studies that rely on all self-report data, the various possible effects of personality variables such as negative affectivity should be explored in preference to ignoring them.     

Cognitive Anxiety and the Decision to Seek Services for Hearing Problems

The purpose of this study was to examine the relationship between a transient state anxiety measure (cognitive anxiety) and the decision to consult for hearing services in older adults. Cognitive anxiety was measured using a content analytic scheme grounded in personal construct psychology. A total of 93 adults with hearing impairment between the ages of 65 and 80 years participated in this study and comprised three groups that occupied different points in the consultation process: a nonconsulting group living in the community, a consulting group seeking evaluation and treatment for hearing impairment, and a group who had received communication consultation and hearing aids. No between-group differences were observed on demographic or objective audiologic measures of hearing impairment. However, as predicted, those who were actively seeking consultation for hearing impairment displayed the highest level of cognitive anxiety, and those who had received consultation and assistance the least, suggesting that difficulties anticipating and interpreting communication situations may play an instigating role in the decision to seek services for hearing impairment.