Deliberate Microbial Infection Research Reveals Limitations to Current Safety Protections of Healthy Human Subjects

Here we identify approximately 40,000 healthy human volunteers who were intentionally exposed to infectious pathogens in clinical research studies dating from late World War II to the early 2000s. Microbial challenge experiments continue today under contemporary human subject research requirements. In fact, we estimated 4,000 additional volunteers who were experimentally infected between 2010 and the present day. We examine the risks and benefits of these experiments and present areas for improvement in protections of participants with respect to safety. These are the absence of maximum limits to risk and the potential for institutional review boards to include questionable benefits to subjects and society when weighing the risks and benefits of research protocols. The lack of a duty of medical care by physician–investigators to research subjects is likewise of concern. The transparency of microbial challenge experiments and the safety concerns raised in this work may stimulate further dialogue on the risks to participants of human experimentation.     

Brand placement disclosure effects on persuasion: The moderating role of consumer self‐control

The inclusion of branded products in media entertainment has become a popular marketing strategy, because viewers are less likely to recognize the persuasive intent of sponsored content as compared with traditional advertising. To guarantee fair communication and protect consumers against unobtrusive persuasion attempts, European media policy has obligated broadcasters to disclose the presence of brand placement in their television shows. Recent studies demonstrate that disclosures raise viewers' persuasion knowledge; however, the circumstances under which brand placement disclosures may affect brand evaluations and resistance to the persuasive impact of brand placement are still unclear. In two experiments, we uncovered self‐control depletion as an important moderator of disclosure effects on brand evaluations and resistance to brand placement influence. Whereas disclosures increase resistance and decrease persuasion for viewers not depleted of their self‐control, disclosures do not affect resistance and even result in more favorable brand evaluations when viewers' self‐control is depleted by a previous self‐control task. Because a state of self‐control depletion can be perceived as the “couch‐potato” mindset in which people expose themselves to entertaining television content, our findings imply that instead of protecting consumers from hidden persuasion, disclosures may unintentionally increase the persuasive effects of brand placement. We discuss several possible mechanisms that could explain our findings. Copyright © 2016 John Wiley & Sons, Ltd.     

Implementing skill-based treatment within a classroom setting for an adolescent with autism

Research exists to support the efficacy of the Interview-Informed Synthesized Contingency Analysis (IISCA) and skill-based treatment (SBT) to address problem behavior within a clinical setting. However, limited research is available to support their use in a classroom setting and especially as a tool to avoid the display of problem behavior altogether. In the current study, the IISCA, informed by an open-ended interview, was conducted with a single participant in the classroom after a prolonged absence from school due to COVID-19. Results of the IISCA were used to determine the multiple contingencies that were likely to evoke problem behavior upon re-introduction of academic task demands. A skill-based treatment was then developed based on these contingencies, which involved teaching the participant functional communication, delay tolerance, and following academic instruction in relevant contexts. After 25 treatment sessions, the participant had acquired and maintained all of these skills, including the ability to functionally communicate, tolerate removal of preferred items, and follow educational instructions within the typical classroom routine. This study shows the applicability of the IISCA and SBT when implemented within the classroom setting and when used to reintroduce educational instruction to an individual with autism after a prolonged break from school.     

Extinction of Within-event Learning Is Contextually Controlled and Subject to Renewal

Five experiments examined within-event learning in rats by inducing an appetite for one of the elements (salt) of a compound stimulus and assessing preference for the other element (almond). Almond preference was conditional upon (1) the almond flavour having been presented in compound with the salt, and (2) the assessment being conducted when the rats were out of sodium balance (Experiment 1). Presentations of the compound in one environment (A) and of the salt and almond elements in a second environment (B) resulted in greater almond preference when rats were tested in A than in B (Experiment 2). Almond preference was reduced when separate presentations of the compound and almond (Experiment 3) or of the compound and salt (Experiment 4) occurred in the same environments but not when these presentations occurred in different environments. Rats exposed to the compound in A and then extinguished to the elements in either A or B showed a reduced almond preference when tested in the extinction environment, but not when tested in the other environment (Experiment 5). Thus, extinction of within-event learning is context-specific and subject to renewal. The results were interpreted in terms of an associative model whereby separate presentations of the elements result in a symmetrical inhibitory link which is contextually gated (Bouton, 1993).     

Long-term memory of pigeons for stimulus-outcome associations involving multiple stimuli, each seen in a single brief trial

Experiment 1 explored performance of pigeons in two versions of a shortterm recognition memory procedure. In one version responding to entirely novel slides was rewarded, and responding to familiar slides (slides seen once, for 10 sec) was not rewarded; in the other version, responding to familiar slides was rewarded. Performance was initially below chance in both versions of the procedure. This result indicated that in this procedure associations were formed between the slides and the outcome (reward or non-reward) that followed their presentation. The result also suggested that the true capacity of pigeon recognition memory cannot be assessed using these procedures, as performance is inevitably disrupted by the bird's associative memory. The tendency of pigeons to form one-trial associations was exploited in Experiment 2. Phase 1 consisted of 16 two-session cycles: in Session 1 of each cycle, birds were shown 20 novel slides and were rewarded for responding to 10 of those slides; in Session 2, the same slides were shown again, with the same reinforcement contingencies. The birds showed significant overnight retention of the one-trial associations formed in Session 1 of each cycle. Phase 2 showed significant retention over periods of more than 20 days of associations involving 320 slides seen twice only. Phase 3 re-exposed for nine daily sessions one of the sets of 20 slides used in Phases 1 and 2; a high level of discrimination emerged rapidly and 4 (of 8) birds showed, by the end of training, no overlap in response rates to positive and negative slides. Comparative implications of the results are discussed.