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OBJECTIVE: To examine dysregulation in biological measures associated with histories of abuse in women and whether women with premenstrual dysphoric disorder (PMDD) differ in their dysregulation. DESIGN: Twenty-five women meeting prospective criteria for PMDD and 42 non-PMDD controls underwent structured interview to determine abuse histories and lifetime Axis I diagnoses, excluding those with current Axis I disorders or using medications. MAJOR OUTCOME MEASURES: Plasma cortisol and norepinephrine (NE), heart rate (HR), blood pressure (BP), and vascular resistance index (VRI) were assessed at rest and in response to mental stress. RESULTS: A greater proportion of PMDD women had prior abuse compared with non-PMDD women. Regardless of PMDD status, all abused women had lower plasma NE and higher HRs and tended to have lower plasma cortisol at rest and during stress. Abused women also reported more severe daily emotional and physical symptoms. Greater VRI and BP at rest and during stress were seen only in PMDD women with abuse. CONCLUSION: There is persistent dysregulation in stress-responsive systems in all abused women that cannot be accounted for by current psychiatric illness or medications, and PMDD women may be differentially more vulnerable to the impact of abuse on measures reflecting alpha-adrenergic receptor function.  相似文献   
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Following Altman's privacy regulation model, this research was based on the assumption that the relationship between achieved and desired levels of privacy is a major determinant of the experience of crowding in small groups. Further, on the basis of evidence that advancing age is associated with a chronic lack of communicative interaction, it was assumed that the achieved level of privacy among elderly persons generally is greater than that experienced by young adults. Given these assumptions, it was predicted that the crowding threshold of young adults would be significantly lower than that of older persons. To test this hypothesis, the research varied conversation distance (close, far) and density (small room, large room) and assessed the quality of communicative interaction and task performance among small groups of college-age females and retired women over 60 years of age. Results showed that task performance among younger subjects deteriorated in close interaction conditions, whereas the performance of older subjects was improved by spatial intrusion. Further, older subjects exhibited positive communication behaviors in response to close conversation, high-density conditions, while younger subjects responded either with negative communication behaviors or were unaffected by spatial restriction. Finally, the research confirmed previous findings that conversation distance is a more important determinant of the experience of crowding in small groups than physical density. The significance of the results for Altman's privacy regulation model and their implications for the study of human communication behaviors were discussed.  相似文献   
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A growing literature has observed a significant reduction in pain sensitivity among hypertensive animals and humans. It is uncertain whether a reduced sensitivity to pain can be observed in nonnotensive individuals who go on to develop high blood pressure. Blood pressure (BP) was reassessed in one hundred fifteen 19-year-old boys initially tested at age 14, when they were also presented with a pain stimulus (mechanical finger pressure). Hierarchical regression analyses indicated that information regarding pain tolerance improved prediction of changes in systolic and diastolic blood pressure beyond that afforded by differences in BP at age 14, parental history of hypertension, and body mass index. These analyses suggest that pain sensitivity may be associated with physiological processes involved in the development of sustained high blood pressure.  相似文献   
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Suicides among older adults in the United States and Canada in the last decade have accounted for an increasing share of all suicides. In both countries the use of firearms among older adults has steadily increased. Despite these trends, little is known about the extent to which crisis centers are prepared to prevent elder suicide. A survey of AAS-listed crisis prevention centers examined the training, knowledge, and current practices relevant to elder suicide among personnel in 321 crisis prevention centers in both countries. Results revealed insufficient training, a lack of familiarity with recent suicide trends, and limited outreach to older adults.  相似文献   
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