基于脑结构像的精神分裂症机器学习分类

将机器学习应用于精神疾患的临床和基础研究是近年来的趋势。研究者将机器学习应用于精神分裂症患者及高危人群的T1加权像和弥散张量成像的脑影像数据中, 为了解疾病的生理病理学机制提供帮助。回顾以往研究发现额叶及颞叶的脑结构特征具有较高的区分能力, 行为数据和脑影像数据结合的分类效果优于单模态数据。现阶段研究存在样本量不足和泛化能力欠缺的局限, 未来研究应注意扩大样本量、制定标准化的分类方法, 从而进一步探究机器学习在精神疾患中的作用。     

Social discounting of pain

Impatience can be formalized as a delay discount rate, describing how the subjective value of reward decreases as it is delayed. By analogy, selfishness can be formalized as a social discount rate, representing how the subjective value of rewarding another person decreases with increasing social distance. Delay and social discount rates for reward are correlated across individuals. However no previous work has examined whether this relationship also holds for aversive outcomes. Neither has previous work described a functional form for social discounting of pain in humans. This is a pertinent question, since preferences over aversive outcomes formally diverge from those for reward. We addressed this issue in an experiment in which healthy adult participants (N = 67) chose the timing and intensity of hypothetical pain for themselves and others. In keeping with previous studies, participants showed a strong preference for immediate over delayed pain. Participants showed greater concern for pain in close others than for their own pain, though this hyperaltruism was steeply discounted with increasing social distance. Impatience for pain and social discounting of pain were weakly correlated across individuals. Our results extend a link between impatience and selfishness to the aversive domain.     

Application of the Minority Stress Theory: Understanding the Mental Health of Undocumented Latinx Immigrants

This paper applies the Minority Stress framework to data collected from an ongoing community-based participatory research project with health and social service agencies in Southeast Michigan. We examine the stressors and coping strategies employed by undocumented Latinx immigrants and their families to manage immigration-related stress. We conducted in-depth interviews with 23 immigrant clients at Federally Qualified Health Care Centers (FQHC) in Southeast Michigan and 28 in-depth interviews with staff at two FQHC's and a non-profit agency serving immigrants. Findings suggest that immigrants face heightened anxiety and adverse mental health outcomes because of unique minority identity-related stressors created by a growing anti-immigrant social environment. Chronic stress experienced stems from restrictive immigration policies, anti-immigrant rhetoric in the media and by political leaders, fear of deportation, discriminatory events, concealment, and internalized anti-immigrant sentiment. Though identity can be an important effect modifier in the stress process, social isolation in the immigrant community has heightened the impact of stress and impeded coping strategies. These stressors have resulted in distrust in community resources, uncertainty about future health benefits, delayed medical care, and adverse mental health outcomes. Findings provide a framework for understanding the unique stressors experienced by immigrants and strategies for interventions by social service agencies.     

THE DIRECT AND GENERALIZED EFFECTS OF SELF INSTRUCTIONS AND PICTURE PROMPTS ON VOCATIONAL TASK PERFORMANCE

We evaluated the effects of self instructions and picture prompts on vocational task performance of three workers with mild to moderate mental retardation. The workers were asked to perform a packaging task that changed daily. Picture prompts were always present. In the verbal training phase, workers learned self instructions regarding the use of picture prompts to cue their performance on the packaging task. In the verbal and task training phase, workers learned to use the self instructions and picture prompts together to guide their task performance. The results showed that verbal training was sufficient for one worker, but that the other two workers required the combined verbal and task training to improve their task performance. For all subjects, there was evidence of generalization of the self management strategies and task performance and maintenance of both over time.     

Bruno Bettelheim and the Chazon Ish: Toward a New Jewish Psychotherapy

Jeremiah is quoted and cited to show the basic optimism of Judaism. Why did Freud create an “Oedipus Complex,” rather than a “Joseph Phenomenon”?—especially since Freud had such a great knowledge of the Bible, including the Joseph story; and the Biblical Joseph made frequent appearances in Freud's dreams. Many of the advances in psychology and psychiatry were made in part as a rebellion against the ideology of psychoanalysis—this includes family therapy, behavioral therapy, and psychopharmacology. Bettelheim saw the shortcomings of psychoanalysis, both as a theory to explain human behavior and as a cure for psychological problems. The experiences of Bettelheim and of The Chazon Ish can give us new hope. The Chazon Ish and Bettelheim both sought to help in the context of a type of community. Reading of the Bible throws light on people's problems; and people can be helped by identification with Biblical characters. There is often specific advice in the Bible. Bible therapy can strengthen the bond between the therapist and the patient, which is important for patient improvement. There is a need for this type of psychotherapy.     

A Review of REBT Research in Alcohol Abuse Treatment

Clinical outcome studies have shown that cognitive-behavioral approaches to alcohol abuse are efficacious. As the research continues to be refined, practitioners can work with clients based on better science. REBT practitioners have developed a number of theoretical and treatment manuals to promote better practice. The empirical literature on REBT treatment for alcohol abuse does not provide strong evidence of its effectiveness. The present article comprehensively reviews the REBT outcome literature and identified six studies. Of these, three met the inclusionary criteria. The findings demonstrated change in endorsement of irrational thinking, with limited behavioral change. Limitations of the present research base for alcohol abuse are discussed and suggestions offered for conducting and reporting REBT research on alcohol abuse.     

Predictors of Appraisal and Psychological Well-Being in Alzheimer's Disease Family Caregivers

The objective of this study was to test a model of stress, appraisal, and adaptation in 114 family caregivers of patients diagnosed with dementia of the Alzheimer's type (white non-Hispanic, N = 64; Hispanic-American, N = 50). Results of structural equation analysis show that appraised caregiver burden played a central role in determining the psychological well-being of family caregivers. The findings indicate that this mediating variable, negative caregiver appraisal, was predicted by increased functional limitations and behavioral disturbances in the patient, poorer perceived physical health, and lower levels of perceived emotional support. Contrary to a priori hypotheses, functional limitations in the patient also exhibited a direct association with caregiver depression. Further, patient cognitive impairment and caregiver ethnicity were not related to caregiver appraisal. Overall, these results support the role of appraised burden in mediating the relationships between caregiving factors and the adaptational outcome of depression. The implications of these findings, limitations of the study, and future directions are discussed.     

Visual Prior Entry

It has long been claimed that attended stimuli are perceived prior to unattended stimuli–the doctrine of prior entry. Most, if not all, studies on which such claims have been based, however, are open to a nonattentional interpretation involving response bias, leading some researchers to assert that prior entry may not exist. Given this controversy, we introduce a novel methodology to minimize the effect of response bias by manipulating attention and response demands in orthogonal dimensions. Attention was oriented to the left or right (i.e., spatially), but instead of reporting on the basis of location, observers reported the order (first or second) of vertical versus horizontal line segments. Although second-order response biases were demonstrated, effects of attention in accordance with the law of prior entry were clearly obtained following both exogenous and endogenous attentional cuing.     

内表型方法在精神疾病研究中的应用

精神疾病在很大程度上受到遗传的影响,而对疾病的遗传学研究却没有得到一致的结论,内表型正是在这一背景下提出。内表型是可以通过生化测试或显微镜检查发现的内在的表现型,即内表型不是很明显的、外在的而是微观的、内在的,内表型比疾病的外在表现更接近疾病的生物学基础,更少受到外在因素的影响,因而通过内表型来研究疾病的遗传基因有着显著的优势。现有的精神疾病诊断和分类标准都是以临床症状和行为描述为基础的,缺少生物学基础,基于内表型的分析对建立疾病的诊断和分类的生物学基础是非常重要的。内表型可以是神经生理的,生物化学的,神经解剖的,认知的,神经心理学的测量。作为内表型需要满足与疾病共同存在,可遗传,状态独立,在家庭中和疾病共分离,在病人未发病亲属中比一般人群的比率要高等标准。该文在介绍了内表型的概念,说明了内表型的原理,优点与用处,以及作为内表型需要满足的标准之后,进而以几种常见的精神疾病（多动症、精神分裂症、抑郁症）为例说明了目前认知内表型研究的进展,其中反应抑制和工作记忆可以作为多动症的内表型,注意、言语记忆和工作记忆可以作为精神分裂症和抑郁症的内表型,文章回顾了它们作为内表型所满足的标准的相关文献。最后对内表型的研究做出了展望