Differential involvement of M1-type and M4-type muscarinic cholinergic receptors in the dorsomedial striatum in task switching

Previous experiments have demonstrated that the rat dorsomedial striatum is one brain area that plays a crucial role in learning when conditions require a shift in strategies. Further evidence indicates that muscarinic cholinergic receptors in this brain area support adaptations in behavioral responses. Unknown is whether specific muscarinic receptor subtypes in the dorsomedial striatum contribute to a flexible shift in response patterns. The present experiments investigated whether blockade of M1-type and/or M4-type cholinergic receptors in the dorsomedial striatum underlie place reversal learning. Experiment 1 investigated the effects of the M1-type muscarinic cholinergic antagonist, muscarinic-toxin 7 (MT-7) infused into the dorsomedial striatum in place acquisition and reversal learning. Experiment 2 investigated the effects of the M4-type muscarinic cholinergic antagonist, muscarinic-toxin 3 (MT-3) injected into the dorsomedial striatum in place acquisition and reversal learning. All testing occurred in a modified cross-maze across two consecutive sessions. Bilateral injections of MT-7 into the dorsomedial striatum at 1 or 2 microg, but not 0.05 microg impaired place reversal learning. Analysis of the errors revealed that MT-7 at 1 and 2 microg significantly increased regressive errors, but not perseverative errors. An injection of MT-7 2 microg into the dorsomedial striatum prior to place acquisition did not affect learning. Experiment 2 revealed that dorsomedial striatal injections of MT-3 (0.05, 1 or 2 microg) did not affect place acquisition or reversal learning. The findings suggest that activation of M1-type muscarinic cholinergic receptors in the dorsomedial striatum, but not M4-type muscarinic cholinergic receptors facilitate the flexible shifting of response patterns by maintaining or learning a new choice pattern once selected.     

When Values and Behavior Conflict: Moral Pluralism and Intrapersonal Moral Hypocrisy

The authors review the various ways moral hypocrisy has been defined and operationalized by social psychologists, concentrating on three general types: moral duplicity, moral double standards, and moral weakness. While most approaches have treated moral hypocrisy as an interpersonal phenomenon, requiring public claims, preaching (versus practicing), or judgments of others (versus oneself), this paper also considers intrapersonal moral hypocrisy – that is, conflicts between values and behavior that may exist even in the absence of public pronouncements or judgments. Current attempts to understand and combat intrapersonal moral hypocrisy are aided by moral pluralism, the idea that there are many different moral values, which may come into conflict both between and within individuals. Examples are given to illustrate how taking into account individual differences in values can help to reduce moral hypocrisy. The authors close by considering the possibility that in a pluralistic world, reducing intrapersonal moral hypocrisy might not always be a normatively desired end goal.     

Distributive Justice Beliefs are Guided by Whether People Think the Ultimate Goal of Society is Well-Being or Power

Abstract

Disagreements about how resources should be distributed are often heated, perhaps because people suspect that distributive justice beliefs that clash with their own derive from nefarious motives. In this paper, we consider a less pessimistic explanation for diversity in distributive justice beliefs: such beliefs are influenced by what one considers the primary utility or value of their society in the first place. In five studies (N?=?21,515), we demonstrate the existence of two separable types of distributive justice beliefs, one (Equality/need) influenced by a focus on societal well-being, and the other (Equity/merit) by a focus on societal power. These findings lend insight into how growing tensions rooted in resource allocation might be defuzed.     

Caste or Christ?

This article offers empirical research using qualitative methodology to identify the presence of the caste system in the Seventh-day Adventist Church in South Asia. The findings are based on the interviews of ten participants aged 18 to 36 from at least four language groups: Tamil, Telugu, Hindi, and Malayalam. All the participants volunteered to participate in the study. Three among the ten did face-to-face interviews, and the remaining seven participants were interviewed online through the Zoom platform. The findings suggest a need to expose and eliminate the discrimination and shame caused by the caste system if the church is to remain faithful to Christ's teaching of equality among the human family.     

The backward masking red light effect in schizophrenia: relationship to clinical features and neurocognitive performance

The "backward masking red light effect" involves a change in visual backward masking performance with a red (compared with a green or gray) background that is in the opposite direction relative to nonpsychiatric controls. This effect has been previously reported in individuals with schizophrenia, their first-degree relatives, and a schizotypy sample. The current study provides the first examination of the relationship of this effect with clinical and neurocognitive measures in a new sample of higher functioning patients with schizophrenia. A location backward masking by pattern task was administered to 16 outpatients with schizophrenia and 21 nonpsychiatric controls. The task was presented on red, green, and gray backgrounds. There was a significant group by color interaction at the 60-ms stimulus onset asynchrony: Participants with schizophrenia tended to decrease accuracy with a red (compared with a gray) background, whereas controls tended to increase accuracy. This interaction remained significant after covarying for baseline (gray) backward masking accuracy. In the schizophrenia patients, a decrease in backward masking accuracy to the red background was correlated with more negative symptoms, lower estimated premorbid IQ, and greater color-word Stroop interference but was not related to positive or disorganized symptoms, age of onset, duration of illness, digit symbol coding performance, or baseline (gray) backward masking accuracy. In contrast, there was no relationship between the red light change score and any of the neurocognitive variables in the control group.     

Lived religious practices: Response to Terry Shoemaker's “World religion and fake news”

One of three short companion essays to Terry Shoemaker's “World Religion and Fake News: A Pedagogical Response in an Age of Post‐Truth,” published in this issue of the journal.     

Menstruation and suicide: an exploratory study

Previous research has reported mixed findings on the effect of the menstrual cycle on suicidal behavior. The contribution of menstruation to completed suicide is also controversial, though the studies are very limited and have not been carefully designed. To explore the relationship, 217 autopsies on completed suicides were performed, matched to a control group at the All India Institute of Medical Sciences in New Delhi. The results show that 54.46% of people who died by suicide were menstruating (results excluded pregnancies), compared to 6.75% of the control group. Menstruation in those who completed suicide, compared to a control group, appeared to have an association with suicide. More research is warranted.