Genetic Testing and Parkinson Disease: Assessment of Patient Knowledge,Attitudes, and Interest

The most common genetic contributor to late-onset Parkinson disease (PD) is the LRRK2 gene. In order to effectively integrate LRRK2 genetic testing into clinical practice, a strategy tailored to the PD population must be developed. We assessed 168 individuals with PD for baseline knowledge of genetics, perceived risk, and interest and opinions regarding genetic counseling and testing. Most participants felt that they were familiar with general genetics terms but overall knowledge levels were low, with an average score of 55%. The majority of participants thought it was likely they inherited a PD gene (72%), believed genetic testing for PD would be useful (86%), and were interested in genetic testing (59%) and genetic counseling (56%). However, only a few participants had heard of any genetic tests for PD (29%) or LRRK2 (10%). There appears to be a significant level of interest in genetics and genetic testing within the PD population, but a considerable deficit in genetics knowledge and an over-estimation of risk. Genetic education and counseling tools to address these needs were developed to provide patients with the ability to make informed and knowledgeable genetic testing decisions.     

Developmental models for children's temperament: alternatives to chronometric polynomial curves

Partridge and Lerner (2007), in a secondary analysis of the New York Longitudinal Study, employed a chronometric polynomial growth curve model to argue that the developmental course of difficult temperament follows a non‐linear trajectory over the first 5 years of life. The free curve slope intercept (FCSI) growth curve model of Meredith and Tisak (1990) is presented as a preferable conceptual alternative because it contains a number of currently popular statistical models, including repeated measures multivariate analysis of variance, factor mean, linear growth, linear factor analysis, and hierarchical linear models as special cases. As such, researchers can compare the fit of each of these models relative to the FCSI model, and, at times, to each other. The present paper conducts a re‐analysis of the data, and establishes that fit of the FCSI model is arguably better than other statistical alternatives. The FCSI model is also used as the basis for identifying subgroups of individuals with their qualitatively distinct growth patterns within a growth mixture modeling framework. Copyright © 2010 John Wiley & Sons, Ltd.     

The impact of visual illusions on perception, action planning, and motor performance

The present study extended recent research revealing that illusions can influence performance in golf putting (Witt, Linkenauger, & Proffitt Psychological Science, 23, 397–399, 2012), by exploring the potential mediating roles of attention and action planning. Glover and Dixon’s (Journal of Experimental Psychology. Human Perception and Performance, 27, 560–572, 2001) planning–control model suggests that both perceptual and movement-planning processes are prone to illusion-based bias. We therefore predicted that both the perception of target size and a measure of attentional control related to movement planning in golf putting (the quiet eye) would be influenced by the illusion. Moreover, as performance could not be corrected using online control (once the ball was struck), we predicted that these biases would also influence performance. We therefore proposed a three-stage process by which illusory context biases perceptual processes, which in turn bias subsequent attentional control related to movement planning, which in turn biases motor performance. Forty novice golfers completed an Ebbinghaus illusion putting task that was designed to manipulate their perceptions of target size, while quiet eye duration and performance (mean radial error) were measured. The results indicated that the illusion was effective in facilitating differences in perceived target size, with perceptually bigger holes promoting longer quiet eye durations and more accurate putting. Follow-up mediation analyses revealed that illusion-based differences in size perception partially mediated illusion-based differences in both quiet eye duration and performance. Moreover, the relationship between illusion-based differences in quiet eye duration and performance was also significant. Future research should further test this three-stage process of bias in other far-aiming tasks in which online control cannot be used.     

Depressive personality styles, dysphoria, and social comparisons in everyday life

"Sociotropic" people are supposedly vulnerable to dysphoria after negative interpersonal events, whereas "autonomous" people are supposedly vulnerable to achievement-related failures. The present study examined whether these personality styles are borne out in social comparison processes. For 3 weeks, 27 sociotropic and 35 autonomous undergraduates completed records of their social comparisons. Depressive personality style moderated comparison frequency and the affective consequences of comparisons, especially for dysphoric individuals: Dysphoric respondents were especially likely to make comparisons in domains that were congruent with their personalities, and comparisons in congruent domains were associated with greater mood change than comparisons in other domains, perhaps especially for dysphoric respondents. These results have implications for the literatures on social comparison and on depressive personality styles.     

Prospective analysis of comorbidity: tobacco and alcohol use disorders

Alcohol use disorders (AUD) and tobacco use disorders (TD) frequently co-occur. The authors examined AUD-TD comorbidity over time using a state-trait (ST) model. The ST model represents variance in AUD/TD as a traitlike factor that spans measurement occasion and identifies distinct sources of variance in AUD-TD comorbidity. The ST model was evaluated on 450 young adults (baseline age = 18.5 years; 51% with family history of alcoholism) assessed 5 times over 7 years. The ST model demonstrated superior fit over a first-order autoregressive model. The tendency to diagnose with AUD and TD was partially explained by family history of alcoholism; this relationship was mediated by childhood stressors, alcohol expectancies, and behavioral undercontrol. Results supported a common third-variable influence (vs. directional) model of comorbidity. The ST model is an important conceptual and methodological approach to the prospective study of comorbidity in general.     

Allegations of wrongdoing: the effects of reinforcement on children's mundane and fantastic claims

S. Garven, J. M. Wood, R. S. Malpass, and J. S. Shaw (1998) found that the interviewing techniques used in the McMartin Preschool case can induce preschool children to make false allegations of wrong doing against a classroom visitor. In this study, 2 specific components of the McMartin interviews, reinforcement and cowitness information, were examined more closely in interviews of 120 children, ages 5 to 7 years. Children who received reinforcement made 35% false allegations against a classroom visitor, compared with 12% made by controls. When questioned about "fantastic" events (e.g., being taken from school in a helicopter), children receiving reinforcement made 52% false allegations, compared with 5% made by controls. In a second interview, children repeated the allegations even when reinforcement had been discontinued. The findings indicate that reinforcement can swiftly induce children to make persistent false allegations of wrong doing.     

Psychological assessment, treatment, and outcome with sex offenders

The frequency and impact of sexual offenses have led to the recent enactment of sexual "predator" laws. Such laws are intended to reduce sexual violence through treatment and involuntary confinement. Sixty years ago, similar laws identifying "sexual psychopaths" were enacted and, in many states, eventually repealed for multiple reasons; among those reasons was an inability to demonstrate that treatment had any significant impact on recidivism. That inability forced us to reexamine, among other issues, the population(s) which undergo treatment, the outcomes that are used to measure treatment effectiveness, and the processes that constitute treatment itself. Those issues are considered in this paper through a review of treatment programs based on psychodynamic, behavioral, and cognitive-behavioral theories. Although the evidence is sparse, it is fair to conclude that the latter have been found to be effective. We call for dynamic measures, effective treatments, and the resources necessary for both developments.     

Story-based scales: development and validation of questionnaires to measure subjective health status and cultural adherence in British Bangladeshis with diabetes

Questionnaires that measure subjective health status are increasingly used in clinical trials. But scales based on the quantification of subjective traits ("rate your feelings on a scale of 1 to 5") and initially developed in western population samples may not be valid for use in minority ethnic groups, even if accurately translated. The measurement of cultural adaptation and assimilation in immigrant groups is important for health research but has well documented methodological challenges. The aim of this study was to develop valid and reliable questionnaires to measure subjective health status and cultural adherence in a minority ethnic group, using the story as the unit of inquiry. The design was a multi-phase study involving (a) narrative interview, (b) vignette construction, (c) questionnaire development, and (d) questionnaire validation in relation to two scales (well-being and cultural adherence) in British Bangladeshis with diabetes. Using data from in-depth narrative interviews (i.e., a non-directive research technique in which the participant is invited to "tell me the story about your diabetes, starting with when you first noticed anything wrong", and the only prompts used are "tell me more about that" or "what happened next?"; Greenhalgh, Helman, & Chowdhury, 1998; Muller, 1999), we constructed culturally congruent vignettes to depict different subjective health states and behaviours. We refined these items in focus group interviews and validated the instruments on 98 Bangladeshi participants, randomly sampled from GP diabetes registers in inner London and interviewed by a Bangladeshi anthropologist. We used factor analysis to explore the underlying structure in the responses to questionnaire items, plus Cronbach alpha tests to measure internal consistency of scales. The questionnaires were acceptable and credible to Bangladeshi participants with diabetes. Ninety of 98 participants were able and willing to complete them with interviewer assistance. Following factor analysis, we produced two definitive instruments. The well-being scale was a single-factor model with four story-based items (measuring depression, anxiety, physical energy, and social activities), with a Cronbach's alpha of .92. The cultural adherence scale was a single-factor model with five items (measuring religious restrictions, ethnic practices, and social ties), with a Cronbach's alpha of .83. In conclusion, this study has produced two important outputs: (a) easy-to-administer, story-based questionnaires that measure well-being and cultural adherence, which are specific to British Bangladeshis with diabetes; (b) a general method for developing story-based instruments to quantify the subjective experience of illness and adherence to cultural norms, which potentially has applications beyond the study population.     

Snatching defeat from the jaws of victory: self-esteem differences in the experience and anticipation of success

Successes--defined broadly as meeting important standards or receiving positive evaluations--are widely assumed to be enjoyed equally by people with high self-esteem (HSEs) and low self-esteem (LSEs). Three studies examined the contradictory hypothesis that HSEs react more favorably to success than do LSEs and that success brings about certain unfavorable consequences for LSEs. Undergraduate participants reacted to a laboratory-manipulated success (Studies 1 and 2) or imagined highly positive events in the future (Study 3). Self-esteem differences emerged in anxiety, thoughts about the self, and (in Study 3) thoughts about non-self-related aspects of the event. LSEs were more anxious than HSEs after succeeding, success improved HSEs' self-relevant thoughts but not LSEs', and LSEs focused more on success's negative aspects.