From synaptic transmission to cognition: an intermediary role for dendritic spines

Dendritic spines are cytoplasmic protrusions that develop directly or indirectly from the filopodia of neurons. Dendritic spines mediate excitatory neurotransmission and they can isolate the electrical activity generated by synaptic impulses, enabling them to translate excitatory afferent information via several types of plastic changes, including neoformation, disappearance, redistribution and changes in geometric shape. The fine line between normal and abnormal excitatory neurotransmission is mediated by the concerted action of glutamate-mediated stimulation and calcium ion entry into spines. Moreover, within the range of normal excitatory activity, dendritic spines undergo specific plastic changes to regulate different forms of afferent information that are often related to distinct modes of cognition-related electrophysiological stimulation, such as long-term potentiation or long-term depression.     

The Concerns about Counseling Racial Minority Clients scale

The purpose of this study was to develop and validate the Concerns about Counseling Racial Minority Clients (CCRMC) scale among counselor trainees. Sample 1 was used for an exploratory factor analysis and confirmatory factor analysis. Four factors were identified, Managing Cultural Differences (α = .82), Offending or Hurting Clients (α = .87), Biased Thoughts and Behaviors (α = .81), and Client Perceptions (α = .77). The coefficient alpha for the CCRMC was .90. The results support the validity of the scale. The scores on the CCRMC and its subscales have positive associations with fear of negative evaluation from others (r = .19 to .40) and negative associations with general counseling self-efficacy (r = -.30 to -.46) and multicultural intervention self-efficacy (r = -.30 to -.64). The CCRMC significantly predicted fear of negative evaluation, session management self-efficacy, and multicultural intervention self-efficacy over and above multicultural social desirability. The validity evidence was not different between White and minority graduate trainees. In Sample 2, the estimated 1-week test-retest reliabilities ranged from .75 to .96 for the CCRMC and its four subscales.     

Its ovr b/n u n me: Technology Use, Attachment Styles, and Gender Roles in Relationship Dissolution

Abstract Relationship dissolution now occurs through technologies like text messaging, e-mail, and social networking sites (SNS). Individuals who experience relationship dissolution via technology may differ in their attachment pattern and gender role attitudes from those who have not had that experience. One hundred five college students (males=21 and females=84) completed an online questionnaire about technology-mediated breakups, attachment style, and gender role attitudes. More than a quarter of the sample had experienced relationship dissolution via technology. Attachment anxiety predicted those subject to technology-mediated breakups. Attachment avoidance and less traditional gender roles were associated with increased likelihood of technology use in relationship dissolution. Implications are discussed in regards to future research and practice.     

Public Voices in Pharmaceutical Deliberations: Negotiating “Clinical Benefit” in the FDA’s Avastin Hearing

This article offers a hybrid rhetorical-qualitative discourse analysis of the FDA’s 2011 Avastin Hearing, which considered the revocation of the breast cancer indication for the popular cancer drug Avastin. We explore the multiplicity of stakeholders, the questions that motivated deliberations, and the kinds of evidence presented during the hearing. Pairing our findings with contemporary scholarship in rhetorical stasis theory, Mol’s (2002) construct of multiple ontologies, and Callon, Lascoumes, and Barthe’s (2011) “hybrid forums,” we demonstrate that the FDA’s deliberative procedures elides various sources of evidence and the potential multiplicity of definitions for “clinical benefit.” Our findings suggest that while the FDA invited multiple stakeholders to offer testimony, there are ways that the FDA might have more meaningfully incorporated public voices in the deliberative process. We conclude with suggestions for how a true hybrid forum might be deployed.     

Spectral Decompositions of Multiple Time Series: A Bayesian Non-parametric Approach

We consider spectral decompositions of multiple time series that arise in studies where the interest lies in assessing the influence of two or more factors. We write the spectral density of each time series as a sum of the spectral densities associated to the different levels of the factors. We then use Whittle’s approximation to the likelihood function and follow a Bayesian non-parametric approach to obtain posterior inference on the spectral densities based on Bernstein–Dirichlet prior distributions. The prior is strategically important as it carries identifiability conditions for the models and allows us to quantify our degree of confidence in such conditions. A Markov chain Monte Carlo (MCMC) algorithm for posterior inference within this class of frequency-domain models is presented. We illustrate the approach by analyzing simulated and real data via spectral one-way and two-way models. In particular, we present an analysis of functional magnetic resonance imaging (fMRI) brain responses measured in individuals who participated in a designed experiment to study pain perception in humans.     

Thomas Aquinas Holds Fast: Objections to Aquinas within Today's Debate on Divine Action

Various authors within the contemporary debate on divine action in nature and contemporary science argue both for and against a Thomistic account of divine action through the notions of primary and secondary causes. In this paper I argue that those who support a Thomistic account of divine action often fail to explain Aquinas' doctrine in full, while those who argue against it base their objections on an incomplete knowledge of this doctrine, or identify it with Austin Farrer's doctrine of double agency – again failing to do Aquinas justice. I analyse these objections, indicating how they do not address Aquinas' doctrine by offering a brief but full account of the latter.     

Validation of the Spanish SIRS With Monolingual Hispanic Outpatients

Psychologists are faced with formidable challenges in making their assessment methods relevant to growing numbers of Hispanic clients for whom English is not the primary or preferred language. Among other clinical issues, the determination of malingering has profound consequences for clients. In this investigation, we evaluated a Spanish translation of the Structured Interview of Reported Symptoms (SIRS; Rogers, Bagby, & Dickens, 1992) with 80 Spanish-speaking Hispanic American outpatients. Using a between-subjects simulation design, the Spanish SIRS was found to produce reliable results with small standard errors of measurement. Regarding validity, very large effect sizes (mean Cohen’s d= 2.00) were observed between feigners and honest responders for the SIRS primary scales. We consider the potential role of the Spanish SIRS with reference to Spanish translations for other assessment instruments.     

Marcos de referencia en el estudio de los mapas cognitivos de ambientes urbanos

Resumen

El presente artículo ofrece una revisión de los estudios realizados en las dos últimas décadas sobre mapas cognitivos aplicados al mundo urbano a partir de las investigaciones llevadas a cabo por los autores de primera línea en el tema. El conjunto de tales trabajos hace patente la falta de articulación en que se encuentra el constructo «mapa cognitivo». Sin embargo, ofrecen unas orientaciones a tener en cuenta necesariamente en cualquier futura investigación.