Activity-Dependent Activation of TrkB Neurotrophin Receptors in the Adult CNS

In this paper we have investigated the hypothesis that neural activity causes rapid activation of TrkB neurotrophin receptors in the adult mammalian CNS. These studies demonstrate that kainic acid-induced seizures led to a rapid and transient activation of TrkB receptors in the cortex. Subcellular fractionation demonstrated that these activated Trk receptors were preferentially enriched in the synaptosomal membrane fraction that also contained postsynaptic glutamate receptors. The fast activation of synaptic TrkB receptors could be duplicated in isolated cortical synaptosomes with KCl, presumably as a consequence of depolarization-induced BDNF release. Importantly, TrkB activation was also observed following pharmacological activation of brain-stem noradrenergic neurons, which synthesize and anterogradely transport BDNF; treatment with yohimbine led to activation of cortical TrkB receptors within 30 min. Pharmacological blockade of the postsynaptic α1-adrenergic receptors with prazosin only partially inhibited this effect, suggesting that the TrkB activation was partially due to a direct effect on postsynaptic cortical neurons. Together, these data support the hypothesis that activity causes release of BDNF from presynaptic terminals, resulting in a rapid activation of postsynaptic TrkB receptors. This activity-dependent TrkB activation could play a major role in morphological growth and remodelling in both the developing and mature nervous systems.     

Skipping breakfast,sedentarism and overweight in children

To show by use of path analysis how in children of 9 and 10 years of age the known relationship between breakfast and high body mass index (BMI) is mediated by sedentary leisure time activities. A random sample of 291 9-year-old and 10-year-old school children from the Principality of Asturias (Spain) was taken. A transversal design was used, their weight and height were measured and an individual standardized interview was carried out in which they were asked about their breakfast habits and the time they spent each week on sedentary leisure activities. Using path analysis, a model was tested in which breakfast habits and leisure time were the independent variables and the BMI was the dependent variable. The results showed that there was an inverse correlation between number of breakfasts and BMI and a direct correlation between the time spent on sedentary leisure activities and BMI. Path analysis showed that the relationship between the frequency with which breakfast was eaten and BMI was mediated by the time spent on sedentary leisure activities. The above appears to confirm the direct role played by failing to have breakfast in the pandemic of obesity as this habit tends to increase children’s BMI. This relationship is, however, mediated by sedentary leisure. According to the data compiled, being overweight in children can only be prevented by modifying not just one of the habits that have been associated with it, but rather the whole group of habits as these appear to make up an obesogenic cluster in which sedentary leisure and not having breakfast are included.     

The free and cued selective reminding test for predicting progression to Alzheimer's disease in patients with mild cognitive impairment: A prospective longitudinal study

Amnestic mild cognitive impairment (aMCI) patients carry a greater risk of conversion to Alzheimer's disease (AD). Therefore, the International Working Group (IWG) on AD aims to consider some cases of aMCI as symptomatic prodromal AD. The core diagnostic marker of AD is a significant and progressive memory deficit, and the Free and Cued Selective Reminding Test (FCSRT) was recommended by the IWG to test memory in cases of possible prodromal AD. This study aims to investigate whether the performance on the FCSRT would enhance the ability to predict conversion to AD in an aMCI group. A longitudinal study was conducted on 88 aMCI patients, and neuropsychological tests were analysed on the relative risk of conversion to AD. During follow‐up (23.82 months), 33% of the aMCI population converted to AD. An impaired FCSRT TR was significantly associated with the risk of conversion to dementia, with a mean time to conversion of 25 months. The FCSRT demonstrates utility for detecting AD at its prodromal stage, thus supporting its use as a valid clinical marker.     

Self-Perceived Health among School-Aged Adolescents: a School-Based Study in Southern Brazil

This study identified which aspects regarding the dimensions of quality of life, in terms of body image, relationships with family and friends, rest and free time, school, well-being and lifestyles function as predictors of self-perceived health among school adolescents in the southern Brazil. The sample was composed of 3360 students, ninth graders in public schools in the metropolitan area of Porto Alegre/RS (Brazil). The instruments used were: a) Health Behaviour in School Children, b) Happiness Overall Life, c) Positive and Negative Affect Scale, d) General Health Questionnaire (GHQ-12), e) Brief Multidimensional Scale of Life Satisfaction in Students (BMSLSS), and f) Subscale of Cohesion of the Family Environment Scale (FES). Multiple linear regression analysis was conducted to identify the predictors of perceived health. The results revealed a model with nine predictor variables in the sense that being more satisfied with one’s own body, perceiving one’s eating habits as healthier compared to others of the same age, having a greater sense of happiness in their current life, being able to talk to one’s brothers/sisters about issues of concern, a perception of being thinner compared to other people of the same age, greater consumption of healthy food, greater presence of positive affects and being male contribute to a greater perception of health. The results show that, for this population, the health issues are beyond the concern over physical health or the presence or absence of symptoms, but also encompass behavioral, relational and psychological aspects, as well.

     

Family identity and severe mental illness: A thematic synthesis of qualitative studies

There is a growing amount of research showing that a shared social identity and the sense of belonging to a family have a potential effect on health. However, little is known about the effects of severe mental illness on family identity. The authors carried out this thematic synthesis based on a systematic review of literature on family narratives of severe mental illness and family identity. The main findings indicate that in many families (i) their identity—as a shared social identity—undergoes a transformation process by which the identity aspects of being a family are reinforced; (ii) family members often take on a caring role as their main family role; and finally, (iii) a cultural component shapes this transformation process. The authors describe implications for research and application in the mental health field. All in all, family identity is transformed by the experience of severe mental illness.     

Physical activity, sedentary leisure, short sleeping and childhood overweight

In this study, using the path analysis, the relation between physical activity, non-regulated activity, sedentary leisure, hours of sleeping, and the body mass index (BMI) was analyzed. The sample was made up of 103 students, 59 girls and 44 boys, aged between 9 and 10 1/2 years. An individual interview was performed in which the children were asked about the TV programs they watched each day of the week; the time they played with the console and the computer; the time dedicated to sports, games and other activities. The results showed that sedentary leisure (number of hours of TV, computer and console) maintains a significant and inverse relation with the hours of sleeping, non-regulated activity (games and others activities), and physical sport activity. The difference between the results of this study and the previous one is discussed, taking into account the recruitment procedure of the participants.     

External support for collaborative problem solving in a simulated provider/patient medication scheduling task

Taking medication requires developing plans to accomplish the activity. This planning challenges older adults because of age-related cognitive limits and inadequate collaboration with health providers. The authors investigated whether an external aid (medtable) supports collaborative planning in the context of a simulated patient/provider task in which pairs of older adults worked together to create medication schedules. Experiment 1 compared pairs who used the medtable, blank paper (unstructured aid), or no aid to create schedules varying in complexity of medication constraints (number of medications and medication co-occurrence restrictions) and patient constraints (available times during the day to take medication). Both aids increased problem-solving accuracy and efficiency (time per unit accuracy) compared to the no-aid condition, primarily for more complex schedules. However, benefits were similar for the two aids. In Experiment 2, a redesigned medtable increased problem-solving accuracy and efficiency compared to blank paper. Both aids presumably supported problem solving by providing a jointly visible workspace for developing schedules. The medtable may be more effective because it externalizes constraints (relationships between medication and patient information), so that participants can more easily organize information. (PsycINFO Database Record (c) 2008 APA, all rights reserved).     

Software Tools in Logic Education: Some Examples

Computers are increasingly present in education and make manyresources and activities available to teachers and pupils. Newpedagogical resources development is very interesting for both.Our digital library Summa Logicae is overtly involved in innovationand pedagogical systematization. It includes some software toolsfor teaching logic developed by computer science students, andin this article we present two of these tools. The MAFIA toolis especially attractive for first year students and helps themto understand the basic concepts of logic in an interactiveway using sematic tableaux. It also allows them to solve thecrazy cases in Mafia which their fellow students from previousyears proposed. The Modelos de Kripke tool, oriented to a moreadvanced level, serves for understanding the link between theproperties of the accessibility relation and the modal formulas,which is at the basis of the current developments of modal logic.     

Solidarity in STEM: How Gender Composition Affects Women’s Experience in Work Teams

The relationships among the percentage of women in a team and women’s sense of team identification and collective efficacy as well as team performance was examined. We explored these relationships in a sample of student teams conducting a semester-long social science research project within the context of science and technology-focused university. Findings with 95 U.S. college students (43 women) show that women experience higher team identification and collective efficacy as the percent of women teammates increases. Additionally, women’s team identification and collective efficacy mediate the relationship between the percentage of women on the team and overall team performance. Interestingly, the number of men on the team did not influence men’s sense of team identification, collective efficacy, or team performance. This research has implications for team composition. Specifically, when navigating diversity in teams, managers and leaders should aim to build teams that are composed of multiple women versus an approach that divides women up among various teams. In doing so, managers can better secure conditions for the development of positive teamwork experiences and, ultimately, performance.