Stress modulates the use of spatial versus stimulus-response learning strategies in humans

Animal studies provided evidence that stress modulates multiple memory systems, favoring caudate nucleus-based "habit" memory over hippocampus-based "cognitive" memory. However, effects of stress on learning strategy and memory consolidation were not differentiated. We specifically address the effects of psychosocial stress on the applied learning strategy in humans. We designed a spatial learning task that allowed differentiating spatial from stimulus-response learning strategies during acquisition. In 13 subsequent trials, participants (88 male and female students) had to locate a "win" card out of four placed at a fixed location in a 3D model of a room. Relocating one cue in the last trial allowed inferring the applied learning strategy. Half of them participated first in the "Trier Social Stress Test." Salivary cortisol and heart rate measurements were taken. Stressed participants used a stimulus-response strategy significantly more often than controls. Subsequent verbal report revealed that spatial learners had a more complete awareness of response options than stimulus-response learners. Importantly, learning performance was not affected by stress. Taken together, stress prior to learning facilitated simple stimulus-response learning strategies in humans-at the expense of a more cognitive learning strategy. Depending on the context, we consider this as an adaptive response.     

Clinical significance of serum phenytoin level]

Phenytoin serum concentrations in 115 epileptics treated on an inpatient basis showed, in two groups, only relatively weak correlation with the dosage used. The range of variation was assigned a factor of 16. For individual patients there was observed a correlation between the dosage in mg/kg and the corresponding phenytoin serum concentration. The level of phenytoin serum concentration was not found to be related to the frequency of attacks. The effective phenytoin serum level showed interindividual differences and can be low as well as relatively high. Resulting from this is the need for determining, from the determination of serum concentrations, the effective serum concentration for each individual patient.     

Post‐It® Note Persuasion: A Sticky Influence

Four studies examine the influence of attaching a seemingly insignificant Post‐it^® note to a survey packet on the likelihood of completing the survey. Participants who received a packet with an affixed Post‐it note request had significantly higher return rates than participants who received the identical survey with (a) no sticky note, (b) the same message written on the cover sheet but without a Post‐it, or (c) a blank Post‐it with no message provided. Furthermore, they returned the materials more promptly with higher quality responses. A more personalized Post‐it appeal increased returns when the survey was long and time consuming but was no more effective than a nonpersonalized Post‐it when the survey was easy to complete. Results suggest that the Post‐it leads the request to be interpreted as a solicitation for a personal favor, facilitating a normative compliance response.     

The relationship between miscellaneous symptoms and major symptom factors in obsessive-compulsive disorder

The diverse symptomatology of obsessive-compulsive disorder (OCD) is being increasingly regarded as reducible to a few symptom dimensions. However, prevailing factor-analytically derived models of symptom structure omit a number of the well-recognized “miscellaneous” symptoms of OCD. This study sought to determine whether miscellaneous OCD symptoms, ascertained by the Yale-Brown Obsessive-Compulsive Scale symptom checklist, could be differentially and reliably predicted by four symptom factors (obsessions and checking, symmetry and ordering, contamination and cleaning, and hoarding) in two independent groups of individuals with OCD (n = 381 and n = 107). Logistic regression analyses were used to determine the association of each of the miscellaneous symptoms with the symptom factors; then a single confirmatory factor analysis was conducted to test the model of associations in the smaller sample. Sixteen (89%) of the 18 symptoms examined were reliably predicted by one (11 items) or two (5 items) of the factors, with obsessions and checking and symmetry and ordering emerging as foremost predictors. The expanded four-factor model showed good fit with data from the second sample. Results are conceptually meaningful, but suggest the inadequacy of groupings based solely upon overt behaviors. These findings may aid clinical understanding of OCD and be of value to studies using symptom factors to guide investigation of its causes and correlates.     

Job insecurity and well-being: The moderating role of job dependence

Job insecurity has become more relevant during the last decades as more flexibility from the workforce and organizations is demanded in the labour market. It has frequently been suggested that job insecurity is a more severe stressor for those who are more dependent on their job. The present study investigates the association between job insecurity and employee well-being by focusing on how employees’ dependence on the job moderates this relationship. Two types of financial dependence (subjective financial dependence and relative contribution to the household income) were studied, along with an indicator of a more psychological dependence on work in general (work involvement). In addition to this, both quantitative and qualitative job insecurity were included. The proposed relations were tested in a sample of Swedish accountancy firm employees. The results of moderated hierarchical regression analyses showed that subjective financial dependence, household contribution, and work involvement moderated the relation between both job insecurity dimensions and job satisfaction. No moderations were found with mental well-being as an outcome. This implies that the extent to which someone depends on their job is important for how job insecurity relates to job satisfaction.     

Age differences in three facets of empathy: performance-based evidence

This study investigated age differences in cognitive and affective facets of empathy: the ability to perceive another's emotions accurately, the capacity to share another's emotions, and the ability to behaviorally express sympathy in an empathic episode. Participants, 80 younger (M(age) = 32 years) and 73 older (M(age) = 59 years) adults, viewed eight film clips, each portraying a younger or an older adult thinking-aloud about an emotionally engaging topic that was relevant to either younger adults or older adults. In comparison to their younger counterparts, older adults generally reported and expressed greater sympathy while observing the target persons; and they were better able to share the emotions of the target persons who talked about a topic that was relevant to older adults. Age-related deficits in the cognitive ability to accurately perceive another's emotions were only evident when the target person talked about a topic of little relevance to older adults. In sum, the present performance-based evidence speaks for multidirectional age differences in empathy.     

Locomotor analysis of the taiep rat

Locomotor activity (tremor, ataxia, immobility, epilepsy, and paralysis) in the taiep rat, which suffers from a myelin deficient disorder, has not been previously documented. This study used walking track analysis of footprints to analyze locomotor activity in the taiep rat in comparison to normal, age-matched controls. The results confirmed differences between normal and taiep rats in terms of stride length, step length, and stride width. In addition, we found significant interactions between age and condition for stride and step length. The results suggest that locomotor analysis is a sensitive indicator of myelin deficiency. The results are discussed in terms of the underlying myelin deficiency and possible treatment regimens.     

Response times in attitudinal items as indicators of the continuous accessibility of knowledge related to attitudes

In the paradigm of social cognition, the measurement of response latencies is important not only for priming procedures directed at the cognitive representation, but also for the assessment of strength-related properties of attitudes. The present paper explored the possibility of using response times as indicators of the continuous accessibility of attitude-relevant knowledge. For two different sets of attitudinal items concerning social welfare (idiographic and nomothetic selection) response times were obtained from a sample of 20 university students. In addition to different reliability coefficients for aggregated response times, information about individual subjects' consistencies and stabilities was obtained. Further, evidence for the validity of response times as indicators of the continuous accessibility of attitude-related knowledge is reported. The aggregated response times had significant correlations with self-report data and interview-related variables (such as number of propositions mentioned) which were obtained by a content analysis of semistructured interviews.     

Incidence of dysarthria in children with cerebellar tumors: a prospective study

The present study investigated dysarthric symptoms in children with cerebellar tumors. Ten children with cerebellar tumors and 10 orthopedic control children were tested prior and one week after surgery. Clinical dysarthric symptoms were quantified in spontaneous speech. Syllable durations were analyzed in syllable repetition and sentence production tasks. Localization of the cerebellar lesions were defined after manual transfer from individual 2D-MR images onto 3D images of a spatially normalized healthy brain. Cerebellar children showed few and mild clinical signs of dysarthria. No difference was present in the sentence production task compared to controls. In five cerebellar children, syllables were prolonged in the syllable repetition task after surgery. Syllable duration normalized in an additional four-week session in all but one case. The MR-analysis showed that superior paravermal cerebellar areas likely involved in dysarthria in adults (paravermal lobules HVI, Crus I) were not significantly affected. In children, speech impairments appear to be rare after cerebellar surgery because tumors most commonly affect posterior-inferior and medial parts of the cerebellum while critical cerebellar regions are likely spared. The results suggest a similar localization of speech functions in the cerebellum in children and adults.     

Different strategies for using motion-in-depth information in catching

Previous studies on ball catching have had the limitation that the catcher was restricted to lateral hand movements. The authors investigated catching behavior in the more natural situation in which hand movements were unconstrained. Movements of the hand were tracked as participants tried to "catch" an approaching ball simulated with changing size and/or changing disparity. Participants used 1 of 2 distinct interception strategies: (a) a "cutting-off" strategy where time to passage (TTP) information was used to guide movements of the hand in depth such that the ball was caught farther in front of the face when the ball was approaching more slowly and (b) a "waiting" strategy where the hand was moved along a frontoparallel plane that was constant across ball trajectories and speeds. Cue dissociation and selective adaptation manipulations demonstrated that the catcher's estimates of TTP and crossing distance were based on a combination of binocular and monocular information.