Enhancing Therapeutic Gains: Examination of Fidelity to the Model for the Intensive Mental Health Program

Given that the development of treatment fidelity assessment protocol is an integral but too frequently ignored aspect of clinical trials for psychological treatments, the Intensive Mental Health Program (IMHP) sought to build fidelity activities into training, program evaluation, and clinical recordkeeping from the outset of a 3 year study period. We describe (a) operational definitions and measurement of the IMHP treatment model, (b) planned fidelity-promoting activities, (c) evaluation methods, and (d) fair to appreciable accomplishment of IMHP fidelity targets. Discussion of the circumstances and processes possibly hindering better fidelity for several IMHP treatment features accompanies presentation of fidelity data. We summarize pitfalls and compensatory strategies identified during IMHP program evaluation and offer practical suggestions to enhance accountability and evaluative activity in future clinical research.     

The role of the dorsal striatum and dorsal hippocampus in probabilistic and deterministic odor discrimination tasks

Three experiments explored the contribution of the cortico-striatal system and the hippocampus system to the acquisition of solutions to simultaneous instrumental odor discriminations. Inactivation of the dorsal striatum after rats had reached criterion on a three problem probabilistic set of discriminations--A (80%) vs. B (20%), C (67%) vs. D (33%), E(67%) vs. F(33%)--impaired test performance and disrupted performance when the rats were tested with novel cue combinations (C vs. F and E vs. D), where control animals chose C and F. In contrast, inactivating the dorsal hippocampus enhanced performance on this task and on a deterministic discrimination A (100%) vs. B (0%). These results are consistent with the complementary learning systems view, which assumes that the cortico-striatal and hippocampal system capture information in parallel. How this information combines to influence task performance depends on the compatibility of the content captured by each system. These results suggest that the trial-specific information captured by the hippocampal system can be incompatible with the across-trial integration of trial outcomes captured by the cortico-striatal system.     

Anxiety sensitivity and obsessive--compulsive disorder

Anxiety sensitivity (AS), a cognitive risk factor for anxiety disorders, was evaluated in a homogeneous obsessive-compulsive disorder (OCD) sample. A total of 280 individuals with OCD completed measures. Evaluation of the Anxiety Sensitivity Index revealed a latent structure that was congruent with previous studies showing a single higher order and three lower order factors, although greater variance was accounted for by the general factor than in a previous study. AS was significantly associated with OCD symptom severity after controlling for other putative cognitive risk factors, although the additional variance explained was small. Variability in the relationship of AS to OCD symptom severity was found across OCD symptom subgroups. Results suggest that AS might be an important aspect of OCD-relevant cognition for specific OCD subgroups, and the need for experimental evaluation is discussed.     

Psychotropic placebos reduce the misinformation effect by increasing monitoring at test

A psychotropic placebo can help people resist the misinformation effect, an effect thought to be caused by a shift to more stringent source monitoring. When this shift occurs has been unclear. To address this issue we gave some people - but not others - a phoney cognitive-enhancing drug we called R273. Shortly afterwards, everyone took part in a misinformation effect experiment. To gather evidence about source monitoring we surreptitiously recorded time to read the misleading postevent narrative, and response time at test. Our findings suggest that people shifted to more stringent source monitoring at test. Moreover, people with higher working memory capacity (WMC) performed better than people with lower WMC - but only when they were told they had received R273, a finding that fits with research showing that WMC can confer advantages in situations demanding effortful control, but not when automatic heuristics suffice.     

Pedro's Significance

Williams's famous story of Jim exemplifies a general class of dilemmas caused by recalcitrant agents. Like Williams himself, most commentators have focused on Jim and the idea that he has special responsibility for his actions. This paper shifts attention to Pedro, exploring his significance in the story and arguing that Jim has a reason not to shoot that depends on Pedro's best possible response. In so doing, it sketches a new approach to the general class of dilemmas posed by recalcitrant agents, drawing attention to the advantages of this approach and to the difficulties it faces and comparing it to rival views associated with Ross and Kamm.     

Efficient spatio-temporal data mining with GenSpace graphs

We describe a method for spatio-temporal data mining based on GenSpace graphs. Using familiar calendar and geographical concepts, such as workdays, weeks, climatic regions, and countries, spatio-temporal data can be aggregated into summaries in many ways. We automatically search for a summary with a distribution that is anomalous, i.e., far from user expectations. We repeatedly ranking possible summaries according to current expectations, and then allow the user to adjust these expectations. We also choose a propagation path in the GenSpace subgraph that reduces the storage and time costs of the mining process.     

Psychopathic Traits in Youth: Is There Evidence for Primary and Secondary Subtypes?

The current study employed model-based cluster analysis in a sample of male adolescent offenders (n = 94) to examine subtypes based on psychopathic traits and anxiety. Using the Psychopathy Checklist: Youth Version (PCL:YV; Forth et al. 2003) and the self-report Antisocial Process Screening Device (APSD; Caputo et al. 1999), analyses identified three clusters in males that varied in the severity of psychopathic traits (low, moderate, and high) and anxiety. The high psychopathic group exhibited more negative personality traits and was judged to be at greater risk for dangerousness whereas the low psychopathic group exhibited more positive personality traits and was judged to be at lower risk for dangerousness. Implications regarding potential developmental differences between adolescent and adult psychopathy, as well as treatment considerations are discussed.