A note on ECG changes observed during Pavlovian conditioning in a rhesus monkey following coronary arterial occlusion

Changes in the ECG of a rhesus monkey during a classical aversive conditioning trial conducted 10 minutes after occlusion of the marginal branch of the left circumflex coronary artery have been observed. This appears to reflect an instance where myocardial ischemia following coronary occlusion was exacerbated by presentation of a conditional stimulus.     

Justice,instruction, and the good: The case for public education in Aristotle and Plato's Laws

This paper develops an interpretation and analysis of the arguments for public education which open Book VIII of Aristotle's Politics, drawing on both the wider Aristotelian corpus and on examination of continuities with Plato's Laws.Part II: Sections IV–VII examine the arguments for the first of the two conclusions which Aristotle advances in VIII. 1, namely that education is important enough to merit the legislator's attention. It is shown, through a development of links between Politics V and the arguments of VIII. 1, that Aristotle's two arguments for this conclusion are calculated to appeal to two distinct subgroups within his intended audience, those who would be moved by a desire to promote the common good, and those who could only be counted on to desire the preservation of their own rule.     

Justice,instruction, and the good: The case for public education in Aristotle and Plato's Laws

This paper develops an interpretation and analysis of the arguments for public education which open Book VIII of Aristotle's Politics, drawing on both the wider Aristotelian corpus and on examination of continuities with Plato's Laws. Part I: The paper opens with the question of why Aristotle would say that no one will doubt that education should be the concern of the legislator, and Sections I–III identify the nature of his enterprise in the Politics, the audience he wishes to address, the conclusions he seeks to establish in VIII. 1, and what public education would amount to for him. An important conclusion reached is that the first of Aristotle's two conclusions in VIII.1 has been routinely misidentified.     

Two-component arterial blood pressure conditional response in rat

The objective of these experiments was to quantify the pattern of change in arterial blood pressure (BP) during a discriminative aversive classical conditioning paradigm in rat using a new “high resolution” computer analysis. Sprague-Dawley rats (n=5) were restrained in a soft, conical cloth pouch and conditioned using a 6 sec. pulsed tone (CS+) followed by a 0.5 sec. tail shock; a steady tone, never followed by shock, served as a CS-. BP peaked at 16.4±6.5 mm Hg (mean±SD) above control at 1.5±0.1 sec. after onset of CS+. This “first component” (“C₁”) also occurred during CS- (12.1±3.8 mm Hg), although the magnitudes of the two were significantly (p<0.05) different. Another group of rats (n=8) was treated identically except the tones were 15 seconds long. The conditional BP response consisted of two components. C₁ was reminiscent of that seen using the short tone: for CS+ a peak of 13.6±5.6 mm Hg at 1.5 sec. or, for CS-, of 10.0±4.3 at 1.3 sec. (p<0.05). In CS+ trials BP peaked again (“C₂,” 7.4±2.5 mm Hg) at 8.3±1.2 sec. There was no statistically significant C₂ for CS- trials, clearly demonstrating discrimination between tones. The unconditional BP response in both groups consisted of two large, closely spaced peaks in BP. Respiration was recorded in 3 additional rats. After shock delivery these subjects often showed a sudden shift between (1) a regular respiratory pattern with moderate chest excursion and (2) apneic episodes interspersed with single, deep breaths. This latter pattern was associated with large, low frequency fluctuations in BP. Continued development of the rat conditioning paradigm is especially warranted because of the ability to record sympathetic nerve activity in intact, awake subjects and the large number of readily available genetic strains, which model human pathological states.     

Relationship between maternal aggression and maternal care in the rat

Aggression among female rats is almost entirely confined to the period of late pregnancy and lactation. Behaviorally it is similar to the aggression of males including piloerection and lateral attacks, but it differs in its function. Unlike male aggression which serves to establish a social hierarchy and a territory, i. e., is competitive, maternal aggression is protective, i. e., it serves to prevent predation of the mother's offspring. In this respect it is closely related temporally and causally to maternal care; if the offspring are removed maternal aggression wanes almost immediately–its function no longer exists! Studies on aggression by mothers, among rats, from the author's laboratory are reviewed and comparisons made with maternal care. As noted, maternal aggression and maternal care are closely related during the cycle of maternal behavior and they share a similar hormonal basis and possibly the effect of uterine stimulation, but maternal care requires prolactin and the decline of progesterone while maternal aggression appears independent of pituitary hormones and does not require a decline in progesterone. Maternal aggression like maternal care appears to be organized into a hormonal phase, during pregnancy, parturition, and for about a week postpartum and a nonhormonal phase thereafter. Bilateral radiofrequency lesions of the lateral midbrain peripeduncular nucleus (PPN) produce deficits in maternal aggression if made on lactation day 7 (L7), but not earlier, without producing significant deficits in maternal behavior. Experiments showed that the PPN does not mediate hormonally stimulated maternal aggression; it appears to mediate only nonhormonally stimulated maternal aggression. Studies on the role of pregnancy hormones on long-term retention of maternal aggression and the role of olfaction in maternal aggression are also reviewed. © 1994 Wiley-Liss, Inc.     

The Logics of Strict-Tolerant Logic

Adding a transparent truth predicate to a language completely governed by classical logic is not possible. The trouble, as is well-known, comes from paradoxes such as the Liar and Curry. Recently, Cobreros, Egré, Ripley and van Rooij have put forward an approach based on a non-transitive notion of consequence which is suitable to deal with semantic paradoxes while having a transparent truth predicate together with classical logic. Nevertheless, there are some interesting issues concerning the set of metainferences validated by this logic. In this paper, we show that this logic, once it is adequately understood, is weaker than classical logic. Moreover, the logic is in a way similar to the paraconsistent logic LP.     

Parallels between depression and lament

This article compares the experiences portrayed by the psalmists in Psalm 31 and Psalm 102, both psalms of lament, with the current concept of major depression. It concludes by exploring how the insights of the psalms may be applied in pastoral care directed toward those who suffer from depression.