Calibrating and constructing models of protein folding

Prediction is more than testing established theory by examining whether the prediction matches the data. To show this, I examine the practices of a community of scientists, known as threaders, who are attempting to predict the final, folded structure of a protein from its primary structure, i.e., its amino acid sequence. These scientists employ a careful and deliberate methodology of prediction. A key feature of the methodology is calibration. They calibrate in order to construct better models. The construction leads to knowledge of how to construct or build an object. Thus, prediction serves a cognitive goal of model construction and not just model or theory testing. The kind of knowledge that results is relevantly different than theoretical knowledge.     

Involuntary language switching in two bilingual patients during the Wada test and intraoperative electrocortical stimulation

We present two bilingual patients without language disorders in whom involuntary language switching was induced. The first patient switched from Dutch to English during a left-sided amobarbital (Wada) test. Functional magnetic resonance imaging yielded a predominantly left-sided language distribution similar for both languages. The second patient switched from French to Chinese during intraoperative electrocortical stimulation of the left inferior frontal gyrus. We conclude that the observed language switching in both cases was not likely the result of a selective inhibition of one language, but the result of a temporary disruption of brain areas that are involved in language switching. These data complement the few lesion studies on (involuntary or unintentional) language switching, and add to the functional neuroimaging studies of switching, monitoring, and controlling the language in use.     

Feminism: What is it Good For? Feminine Norms and Objectification as the Link between Feminist Identity and Clinically Relevant Outcomes

The goal of this study was to explore the relationships between feminism and clinical outcomes, such as eating attitudes, depression, and self-esteem, employing structural equation modeling to look at indirect relationships. This study examined female participants’ (N = 282) responses to an online survey measuring feminist self-identification, conformity to feminine norms, objectified body consciousness, eating attitudes, depression, and self-esteem. Participants were recruited on two college campuses and through online listservs. Feminist self-identification was related to rejecting the feminine norms of thinness, appearance, and the importance of romantic relationships. Endorsing these norms was related to increased body surveillance and shame. Objectification variables were related to negative clinical outcomes. Thus, feminism is a distal, rather than proximal, influence on clinical variables.     

Learning effects on sperm competition and reproductive fitness

Learning and other common psychological processes presumably evolved because they contribute to reproductive fitness, but reproductive outcomes are rarely measured in psychology experiments. We examined the effects of Pavlovian conditioning on reproductive fitness in a sperm-competition situation. Typically, two males mating with the same female in immediate succession sire similar numbers of offspring. In a study with domesticated quail (Coturnix japonica), we increased paternity success by presenting a Pavlovian signal that permitted one of two competing males to predict copulatory opportunity. Using microsatellite-based DNA fingerprinting, we found that signaled males sired 72% of the offspring when competing with control males, and this effect was independent of copulation order. In the absence of Pavlovian conditioning, rates of fertilization were not significantly different for two males that copulated with the same female. These findings demonstrate that Pavlovian conditioning contributes to reproductive fitness and suggest that individual past experience can bias genetic transmission and the evolutionary changes that result from sexual competition.     

Caregiver Demand and Parent Distress in Juvenile Rheumatic Disease: The Mediating Effect of Parent Attitude Toward Illness

Parents of youth with juvenile rheumatic diseases (JRD) often take on illness management responsibilities that can become burdensome, potentially resulting in poor parent adjustment outcomes. However, not all caregivers will experience increased distress as a result of variability in stress appraisals. The current study examined the role of parent illness attitudes in the relation between perceived caregiver demand and parental distress. Youth (N = 70) ages 7–18 years diagnosed with a JRD and their parents were recruited from a pediatric rheumatology clinic. Parents completed measures of caregiver demand, parental distress, and illness attitudes. Hierarchical regression revealed a relationship between caregiver demand and parental distress. A significant relationship was also found between caregiver demand and parent illness attitudes, as well as parent illness attitudes and parental distress. Thus, parent illness attitudes mediated the relationship between caregiver demand and parental distress. Techniques aimed at altering negative illness attitudes may help parents cope with their caregiving responsibilities.     

Origins of a stereotype: categorization of facial attractiveness by 6-month-old infants

Like adults, young infants prefer attractive to unattractive faces (e.g. Langlois, Roggman, Casey, Ritter, Rieser‐Danner & Jenkins, 1987 ; Slater, von der Schulenburg, Brown, Badenoch, Butterworth, Parsons & Samuels, 1998 ). Older children and adults stereotype based on facial attractiveness ( Eagly, Ashmore, Makhijani & Longo, 1991 ; Langlois, Kalakanis, Rubenstein, Larson, Hallam & Smooth, 2000 ). How do preferences for attractive faces develop into stereotypes? Several theories of stereotyping posit that categorization of groups is necessary before positive and negative traits can become linked to the groups (e.g. Tajfel, Billig, Bundy & Flament, 1971 ; Zebrowitz‐McArthur, 1982 ). We investigated whether or not 6‐month‐old infants can categorize faces as attractive or unattractive. In Experiment 1, we familiarized infants to unattractive female faces; in Experiment 2, we familiarized infants to attractive female faces and tested both groups of infants on novel faces from the familiar or novel attractiveness category. Results showed that 6‐month‐olds categorized attractive and unattractive female faces into two different groups of faces. Experiments 3 and 4 confirmed that infants could discriminate among the faces used in Experiments 1 and 2, and therefore categorized the faces based on their similarities in attractiveness rather than because they could not differentiate among the faces. These findings suggest that categorization of facial attractiveness may underlie the development of the ‘beauty is good’ stereotype.     

Effects of the "beauty is good" stereotype on children's information processing

The authors tested schematic information processing as a function of attractiveness stereotyping in two studies. An adult experimenter read children (ages 3 to 7 years) eight different stories in which a child narrator encountered two characters who varied in level of attractiveness and displayed positive or negative traits that were either consistent or inconsistent with the "beauty is good" stereotype. Following the story, the experimenter showed each child a photograph of the two characters' faces and asked the child to point to the character who displayed the positive trait. In Experiment 1, children made more errors in identifying female characters with stereotype inconsistent traits but did just the opposite with male characters. Experiment 2 replicated the findings with female characters but found no difference in errors with male characters. The findings have implications for how attractiveness and gender stereotypes affect children's information processing, how attractiveness schemata may be organized, and why physical attractiveness stereotypes are maintained.     

Evaluation of a behavioral measure of risk taking: the Balloon Analogue Risk Task (BART)

The present study (N = 86) sought to evaluate a laboratory-based behavioral measure of risk taking (the Balloon Analogue Risk Task; BART) and to test associations between this measure and self-report measures of risk-related constructs as well as self-reported real-world risk behaviors. The BART evidenced sound experimental properties, and riskiness on the BART was correlated with scores on measures of sensation seeking, impulsivity, and deficiencies in behavioral constraint. Also, riskiness on the BART was correlated with the self-reported occurrence of addictive, health, and safety risk behaviors, with the task accounting for variance in these behaviors beyond that accounted for by demographics and self-report measures of risk-related constructs. These results indicate that the BART may be a useful tool in the assessment of risk taking.     

Argumentum Ex Divinatione: Divination and Civic Argument in the Ancient World

This argument explores transcultural commonalities among civic arguments from divination in global antiquity. In the ancient world, proponents engaged in kisceral arguments deriving from divinatory signs: arguments ex divinatione regarding prospective civic action. Under ideal circumstances, their aim was to help insure that the collective action of human political organizations was aligned with the natural synchrony of the cosmos. Thus, civic arguments from divination were employed to anticipate the future’s course based on the signs the system produced holistically. In ancient Mesopotamia, China, and Rome, divination was employed as a tool for aligning the order of human society to that of a conception of metaphysical or cosmic order. By comparing these argumentative examples and rationales, we see a broader context for the way in which humans made arguments toward political futurity outside more conventional syllogistic formulations concerning causation. Rather, the argumentative strategies of many ancient cultures embraced an understanding of the future as the logical outcome of a holistic dynamism in kairotic time.