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This study sought to determine the effect of a single intraperitoneal injection of methylchloroethamine on the long-term activity response of immature, male, Holtzmann albino rats. The 10 experimental Ss showed a significant progressive decline in activity up to 110 days after injection. The activity of the control Ss over the same period showed random variation. A subsidiary finding was a significantly faster weight gain for the experimental Ss than for the control Ss. 相似文献
754.
Deregulated semantic cognition contributes to object‐use deficits in Alzheimer's disease: A comparison with semantic aphasia and semantic dementia 下载免费PDF全文
Faye Corbett Elizabeth Jefferies Alistair Burns Matthew A. Lambon Ralph 《Journal of Neuropsychology》2015,9(2):219-241
Executive control is impaired from the early stages of Alzheimer's Disease (AD) and this produces deregulated semantic cognition (Corbett, Jefferies, Burns, & Lambon Ralph, 2012 ; Perry, Watson, & Hodges, 2000 ). While control deficits should affect semantic retrieval across all modalities, previous studies have typically focused on verbal semantic tasks. Even when non‐verbal semantic tasks have been used, these have typically employed simple picture‐matching tasks, which may be influenced by abnormalities in covert naming. Therefore, in the present study, we examined 10 patients with AD on a battery of object‐use tasks, in order to advance our understanding of the origins of non‐verbal semantic deficits in this population. The AD patients’ deficits were contrasted with previously published performance on the same tasks within two additional groups of patients, displaying either semantic degradation (semantic dementia) or deregulation of semantic retrieval (semantic aphasia; Corbett, Jefferies, Ehsan, & Lambon Ralph, 2009 ). While overall accuracy was comparable to the scores in both other groups, the AD patients’ object‐use impairment most closely resembled that observed in SA; they exhibited poorer performance on comprehension tasks that placed strong demands on executive control. A similar pattern was observed in the expressive domain: the AD and SA groups were relatively good at straightforward object use compared to executively demanding, mechanical puzzles. Error types also differed: while all patients omitted essential actions, the SA and AD groups’ demonstrations also featured unrelated intrusions. An association between AD patients’ object use and their scores on standard executive measures suggested that control deficits contributed to their non‐verbal semantic deficits. Moreover, in a task specifically designed to manipulate executive demand, patients with AD (and SA) exhibited difficulty in thinking flexibly about the non‐canonical uses of everyday objects, especially when distracted by semantically related objects. This study provides converging evidence for the notion that a failure of regulatory control contributes to multimodal semantic impairment in AD and uniquely demonstrates this pattern for the highly non‐verbal domain of object use. 相似文献
755.
We present sentence reading data from a large-scale study with children (N = 632), focusing on three key research questions. (1) What are the trajectories of reading development in oral as compared to silent reading? (2) How are word frequency effects developing and are changes differentially affected by reading mode? (3) Are there systematic differences between better and weaker comprehenders when reading silently vs. aloud? Results illuminate a number of differences between reading modes, including more and prolonged fixations in oral reading, along with less inter-word regressions and attenuated effects of word frequency. Weaker comprehenders were slower, especially in oral reading and showed less flexibility in the allocation of word processing time. Differences between reading modes can be explained by additional processing demands imposed by concurrent articulation and eye–voice coordination when reading aloud. 相似文献
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Hofmann Markus J. Kleemann Mareike A. Roelke-Wellmann André Vorstius Christian Radach Ralph 《Cognitive processing》2022,23(2):309-318
Cognitive Processing - While most previous studies of “semantic” priming confound associative and semantic relations, here we use a simple co-occurrence-based approach to examine... 相似文献
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Seth P Patel SN Sales JM DiClemente RJ Wingood GM Rose ES 《Psychology, health & medicine》2011,16(3):346-356
Adolescents, particularly African American adolescents, are at high risk for sexually transmitted infections (STIs). The association between psychosocial factors and risky sexual behavior has been well established. However, only a small number of studies have examined the relationship between depressive symptomatology among African American female adolescents, specifically over time. The present study examined depressive symptoms as a predictor of risky sexual behavior, sexual communication, and STIs longitudinally among African American female adolescents between the ages 15 and 21. Binary generalized estimating equation models were conducted assessing the impact of depressive symptoms at baseline on risky sexual behavior and STIs over six- and 12-months follow-up. Age, intervention group, and baseline outcome measures were entered as covariates. The results indicated that high levels of depressive symptoms predicted no condom use during last sexual encounter and multiple sexual partners over six-months follow-up. Depressive symptoms also predicted having a main partner with concurrent partners, high fear of communication about condoms, and sex while high on alcohol or drugs over six- and 12-months follow-up. These findings could be used to inform HIV/STI prevention intervention programs and clinicians providing regular health care maintenance to African American female adolescents engaging in risky sexual behavior. 相似文献
759.
Stephen Hetherington 《Ratio》2011,24(2):176-191
Analytic epistemologists reach regularly for favoured ‘intuitions’. And the anti‐luck intuition (as Duncan Pritchard calls it) is possibly one of the best‐entrenched epistemological intuitions at present, seemingly guiding standard reactions to Gettier situations. But why is that intuition true (if it is)? This paper argues that the anti‐luck intuition (like the ability intuition) rests upon something even more deeply explanatory – the normality intuition. And to recognise this is to understand better what most epistemologists want from a concept of knowledge. (It also helps to explain recent epistemological reactions to lottery cases.) 1 1 Duncan Pritchard gave me very helpful comments on a draft of this paper.
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760.
Ralph William Clark 《Philosophia》2011,39(2):251-265
I defend what I believe to be a new variation on Kripkean themes, for the purpose of providing an improved way to understand
the referring functions of proper names. I begin by discussing roles played by perceptual perspectives in the use of proper
names, and then broaden the discussion to include what I call “cognitive perspectives.” Although both types of perspectives
underwrite the existence of intentional intermediaries between proper names and their referents, the existence of these intentional
intermediaries does not entail that a Kripke-inspired view of direct reference must be abandoned. At the same time, the existence
of these intermediaries can be seen to play illuminating roles as regards the referring functions of proper names in the following
types of cases, among others: (a) where different names pick out the same subject; (b) where names are empty. Along the way,
I argue that “perspectival views” are not something “inside the head” of language users as intended by Putnam in his well-known
discussion of meaning. 相似文献