Optimization of Blocked Designs in fMRI Studies

Blocked designs in functional magnetic resonance imaging (fMRI) are useful to localize functional brain areas. A blocked design consists of different blocks of trials of the same stimulus type and is characterized by three factors: the length of blocks, i.e., number of trials per blocks, the ordering of task and rest blocks, and the time between trials within one block. Optimal design theory was applied to find the optimal combination of these three design factors. Furthermore, different error structures were used within a general linear model for the analysis of fMRI data, and the maximin criterion was applied to find designs which are robust against misspecification of model parameters.     

A beginner's guide to the problem-oriented first family interview

The large volume and diversity of family therapy resources can often confuse trainees who are in need of more abbreviated guidelines for managing their clinical responsibilities. This paper presents a structured outline of a problem-oriented first family interview for the family therapy supervisor and the beginning family therapist. We view the first interview as an integrated process including the important tasks preceding and following the initial family meeting. After the goals that shape the work of the first interview are described, a step-by-step guide to the twelve phases of the interview is presented: telephoning; forming hypotheses; the greeting; the social phase; identifying the problem; observing family patterns; defining goals; contracting; checklist; revising hypotheses; contacting the referral person; and gathering records. This approach to the first interview integrates a variety of structural and strategic procedures. The guide, intended for use in conjunction with close supervision, may serve as a foundation on which beginning therapists can build their unique styles.     

Subjective well‐being in times of social change: Congruence of control strategies and perceived control

This paper investigates the association between perceptions of broader changes in the social‐ecological context and individuals’ subjective well‐being (SWB). Macro‐level societal changes such as globalization or demographic change give rise to new demands for individual functioning at work and/or in the family. Such new demands associated with social change are stressful and likely to be related to lower levels of SWB. Being active agents, individuals attempt to deal with social change and its increasing demands to protect their SWB. The present study investigates which kinds of control strategies are most effective in protecting one's SWB. Specifically, we predicted that control strategies of goal engagement will be most effective under conditions of perceived high control, and control strategies of goal disengagement will be most effective under conditions of perceived low control. In a large sample of 2537 German adults, work‐ and family‐related demands associated with social change were found to be negatively linked to SWB. Moreover and in line with the motivational theory of lifespan development, control strategies of goal engagement and disengagement were beneficial for SWB to the extent that they matched the perceived control of the demands associated with social change.     

What clocks tell us about the neural correlates of spatial imagery

We review a series of experimental studies aimed at answering some critical questions about the neural basis of spatial imagery. Our group used functional magnetic resonance imaging (fMRI) to explore the neural correlates of an online behaviourally controlled spatial imagery task without need for visual presentation—the mental clock task. Subjects are asked to imagine pairs of times that are presented acoustically and to judge at which of the two times the clock hands form the greater angle. The cortical activation elicited by this task was contrasted with that obtained during other visual, perceptual, verbal, and spatial imagery tasks in several block design studies. Moreover, our group performed an event‐related fMRI study on the clock task to investigate the representation of component cognitive processes in spatial imagery. The bulk of our findings demonstrates that cortical areas in the posterior parietal cortex (PPC), along the intraparietal sulcus, are robustly involved in spatial mental imagery and in other tasks requiring spatial transformations. PPC is bilaterally involved in different kinds of spatial judgement. Yet the degree to which right and left PPC are activated in different tasks is a function of task requirements. From event‐related fMRI data we obtained evidence that left and right PPC are activated asynchronously during the clock task and this could reflect their different functional role in subserving cognitive components of visuospatial imagery.     

Reflex Responses of Human Lip Muscles to Mechanical Stimulation During Speech

The role played by reflex pathways in the production of movement has been a significant issue for motor control theorists interested in a wide variety of motor behaviors. From studies of locomotion and chewing, it appears that gains in reflex pathways can be altered so that activity in these pathways does not produce destabilizing responses during movement. In speech production, recent experimental evidence has been interpreted to suggest that autogenetic lip reflexes (perioral reflexes) are suppressed during sustained phonation or speech production. The present study was conducted to assess the effects of phonation, direction of movement, and ongoing speech production on reflex responses of lip muscles. The present results suggest, in contrast to earlier work, that this reflex pathway is not suppressed during phonation or speech. However, the response may appear to be suppressed or absent because the amplitude of the observed response depends upon the activation levels of the various muscles of the lower lip and, therefore, indirectly on the nature of the gesture the subject is instructed to produce.     

First and second language in the brain: Neuronal correlates of language processing and spelling strategies

This study explores oscillatory brain activity by means of event-related synchronization and desynchronization (%ERS/ERD) of EEG activity during the use of phonological and orthographic-morphological spelling strategies in L2 (English) and L1 (German) in native German speaking children. EEG was recorded while 33 children worked on a task requiring either phonological or orthographic-morphological spelling strategies. L2 processing elicited more theta %ERS than L1 processing (particularly at bilateral frontal and right posterior parietal sites) which might suggest a stronger involvement of semantic encoding and retrieval of the less familiar L2. The highest level of theta %ERS was revealed for the orthographic-morphological strategy in L2 which might indicate a more intense way of lexical retrieval compared to the phonological strategy in L2 and the orthographic-morphological strategy in L1. Analyses moreover revealed that phonological processing (both in L1 and L2) was associated with comparatively strong left-hemispheric %ERD in the upper alpha frequency band.     

BDNF is a novel marker of cognitive function in ageing women: the DR's EXTRA Study

Brain-derived neurotrophic factor (BDNF) is one of the key molecules modulating brain plasticity. While low circulating levels of BDNF have been suggested to predispose to Alzheimer's disease, very little data are available on its association with cognitive function in general population. We evaluated the association between plasma BDNF levels and cognition in a representative population sample of ageing men and women. The subjects (n=1389) were participants of the Dose-Responses to Exercise Training (DR's EXTRA) Study and represent a random sample of Eastern Finnish people (684 men and 705 women), 57-79 years of age at baseline of the study. Plasma BDNF levels were measured by enzyme-linked immunosorbent assay (ELISA). Cognitive function was evaluated using the Consortium to Establish a Registry for Alzheimer's Disease (CERAD) neuropsychological test battery. Women had a higher mean (+/-SEM) plasma BDNF level than men (1721+/-55vs. 1495+/-54pg/ml, P<0.001). In women, 1 SD decrease in BDNF increased the risk for a low score in Naming Test by 53% (95% CI 1.21-1.92, P<0.001), in Mini-Mental State Examination by 63% (95% CI 1.21-2.20, P=0.001), in Word List Memory by 56% (95% CI 1.08-2.26, P=0.019), in Word List Recall by 50% (95% CI 1.10-2.05, P=0.010), in Word List Saving by 49% (95% CI 1.12-1.99, P=0.007), and in Word List Recognition by 64% (95% CI 1.19-2.25, P=0.002). Data were adjusted for age, education, depression, impaired glucose metabolism, cardiovascular disease, antihypertensive medication, lipid lowering medication, use of sex hormones, smoking, alcohol consumption, storing time of plasma in the freezer and platelet count. BDNF was not associated with cognition in men. Present data suggest that plasma BDNF is a biomarker of impaired memory and general cognitive function in ageing women.     

Why Should I Help You? Man Up! Bystanders’ Gender Stereotypic Perceptions of a Cyberbullying Incident

Bystanders observing a cyberbullying incident do not always intervene in favor of the victim. We argue that gender stereotypic perceptions of female versus male victims contribute to the differential reactions of bystanders to cyberbullying incidents. Results of a scenario-based experiment show that participants with moderate or high levels of sexist attitudes are more empathic toward a female victim of workplace cyberbullying. Consequently, a female victim is more likely to receive help. Female victims are less likely to be attributed blame if the perpetrator is male. The results imply that male victims of cyberbullying are marginalized by their social environment.     

Psychotherapie und Internet

Zusammenfassung  Die Außendarstellung im Internet ist wichtig und in der Zukunft unverzichtbar. Jedoch hat die Liberalisierung des Werberechts der freien Berufe keineswegs zur absoluten Schrankenlosigkeit geführt. Vielmehr sind die zu beachtenden Regeln auf verschiedene Gesetze und Rechtsgebiete verstreut, so dass ohne fachkundige Hilfe—etwa durch die Kammern oder durch juristische Beratung—die Selbstdarstellung im Internet schnell zu einem bösen Erwachen führen kann.