Why do we take drugs? From the drug-reinforcement theory to a novel concept of drug instrumentalization

The drug-reinforcement theory explains why humans get engaged in drug taking behavior. This theory posits that drugs of abuse serve as biological rewards by activating the reinforcement system. Although from a psychological and neurobiological perspective this theory is extremely helpful, it does not tell us about the drug-taking motives and motivation of an individual. The definition of drug instrumentalization goals will improve our understanding of individual drug-taking profiles.     

When Fluency Signals Truth: Prior Successful Reliance on Fluency Moderates the Impact of Fluency on Truth Judgments

Repeated statements are more frequently judged to be true. One position relates this so‐called “truth effect” to metacognitive experiences of fluency, suggesting that repeated statements are more frequently judged to be true because they are processed more fluently. Although most prior research focused on why repetition influences truth judgments, considerably less is known about when fluency is used as information. The present research addresses this question and investigates whether reliance on fluency is moderated by learning experiences. Specifically, we focus on changes in the reliance on fluency over the course of time. A series of experiments reveals that fluency is more likely to be used in truth judgments when previous reliance on fluency has resulted in valid judgments, compared with when previous reliance on fluency was misleading. These findings suggest that reliance on fluency in judgments is a finely tuned process that takes prior experiences with fluency‐based judgments into account. Copyright © 2013 John Wiley & Sons, Ltd.     

Individual Differences in Antisocial Punishment in Public Goods Situations: The Interplay of Cortisol with Testosterone and Dominance

This research investigates which endocrinological and psychological factors are associated with individuals' tendency to engage in destructive antisocial punishment, that is, to costly punish cooperative individuals in public goods situations. In this work, we focus on the interplay of endogenous cortisol with testosterone and dominance. We applied the dual‐hormone hypothesis according to which testosterone is positively associated with destructive and dominant behavior but only in individuals with low levels of cortisol. Study 1 shows that individuals are more likely to engage in destructive antisocial punishment in a public goods game with the option to punish when their testosterone level is high, given that their level of cortisol is low, which bolsters the dual‐hormone hypothesis. In contrast, no significant interaction effect of testosterone and cortisol emerges for the punishment of uncooperative free‐riders (altruistic punishment). In a second study, we build on these findings and document that self‐reported dominance is only positively associated with antisocial punishment (but not with altruistic punishment) when cortisol is low. In sum, the results indicate the importance of taking endocrinological and psychological factors (and their interactions) into account in order to reach a comprehensive understanding of individuals' behavior in social dilemma situations. Copyright © 2013 John Wiley & Sons, Ltd.     

Short report: correlates of functional disability with disease activity in elderly patients with rheumatoid arthritis

Rheumatoid arthritis (RA) prevalence increases with age and old people are special patient population. The recognition of functional disability related to RA could be challenging in elderly patients because aging itself and potential co-morbid disease may also cause functional disability. In this study, we aimed to look at the correlation between disease activity and functional disability in elderly RA patients. Elderly RA patients, ≥65 years old at their routine visits were included in the study. The composite ‘disease activity score’ in 28 joints (DAS-28) was used to determine disease activity groups. Health assessment questionnaire (HAQ) scores were calculated to describe the functional disability and compared across the disease activity groups. Two hundred and fifty-eight RA patients with the mean age of 71 ± 5 (65–90) and a total disease duration of 8.4 ± 8.5 (.5–50) years were recruited. The proportion of patients with high and moderate disease activity was 70%. HAQ scores were significantly correlated with disease activity (p < .05). Functional disability estimated by HAQ was correlated with disease activity in elderly patients with RA     

Eye blink detection for different driver states in conditionally automated driving and manual driving using EOG and a driver camera

In this article, we examine the performance of different eye blink detection algorithms under various constraints. The goal of the present study was to evaluate the performance of an electrooculogram- and camera-based blink detection process in both manually and conditionally automated driving phases. A further comparison between alert and drowsy drivers was performed in order to evaluate the impact of drowsiness on the performance of blink detection algorithms in both driving modes. Data snippets from 14 monotonous manually driven sessions (mean 2 h 46 min) and 16 monotonous conditionally automated driven sessions (mean 2 h 45 min) were used. In addition to comparing two data-sampling frequencies for the electrooculogram measures (50 vs. 25 Hz) and four different signal-processing algorithms for the camera videos, we compared the blink detection performance of 24 reference groups. The analysis of the videos was based on very detailed definitions of eyelid closure events. The correct detection rates for the alert and manual driving phases (maximum 94%) decreased significantly in the drowsy (minus 2% or more) and conditionally automated (minus 9% or more) phases. Blinking behavior is therefore significantly impacted by drowsiness as well as by automated driving, resulting in less accurate blink detection.     

Parkinson’s Disease: Patients’ Knowledge,Attitudes, and Interest in Genetic Counseling

The objective of this study was to assess the genetics knowledge of patients with Parkinson’s disease (PD), and to explore their attitudes on genetic testing and interest in genetic counseling. We surveyed 158 patients from the University of Maryland Parkinson’s Disease and Movement Disorders Center. Patients averaged a score of 63% on general genetics knowledge and 73% on PD genetics knowledge. Participants had an overall positive attitude toward genetic testing: 80% believed that the use of genetic tests among people should be promoted, and 83% would undertake genetic test for PD if it was available. Patients reported a high interest to discuss the benefits, risks, and impacts of genetic testing for PD (mean sum score?=?26, range?=?9–35), and 43% patients expressed interest in meeting with a genetic counselor. Multivariate regression analysis showed that patients who had more positive attitudes toward genetic testing for PD were more interested in meeting with a genetic counselor (β?=?0.6, p?<?0.001). This study is the first to demonstrate an interest in genetic counseling among patients with PD. Our findings demonstrate a new niche for genetic counselors to support patients in clarifying gaps or misconceptions in knowledge about PD genetics as well as the possible risks, benefits, and limitations of genetic testing.     

Different contexts change the impression of animacy

The aim of this research was to explore the effect of different spatiotemporal contexts on the perceptual saliency of animacy, and the extent of the relationship between animacy and other related properties such as emotions and intentionality. Paired-comparisons and ratings were used to compare the impressions of animacy elicited by a small square moving on the screen, either alone or in the context of a second square. The context element was either static or moving showing an animate-like or a physical-like trajectory, and the target object moved either toward it or away from it. The movement of the target could also include animacy cues (caterpillar-like expanding/contracting phases). To determine the effect of different contexts on the emergence of emotions and intentions, we also recorded and analysed the phenomenological reports of participants. The results show that the context significantly influences the perception of animacy, which is stronger in dynamic contexts than in static ones, and also when the target is moving away from the context element than when it is approaching it. The free reports reveal different proportions in emotional or intentional attributions in the different conditions: in particular, the "moving away" condition is related to negative emotions, while the "approaching" condition evokes positive emotions. Overall, the results suggest that animacy is a graded concept that can be articulated in more general characteristics, like simple aliveness, and more specific ones, like intentions or emotions, and that the spatiotemporal contingencies of the context play a crucial role in making them evident.