BDNF is a novel marker of cognitive function in ageing women: the DR's EXTRA Study

Brain-derived neurotrophic factor (BDNF) is one of the key molecules modulating brain plasticity. While low circulating levels of BDNF have been suggested to predispose to Alzheimer's disease, very little data are available on its association with cognitive function in general population. We evaluated the association between plasma BDNF levels and cognition in a representative population sample of ageing men and women. The subjects (n=1389) were participants of the Dose-Responses to Exercise Training (DR's EXTRA) Study and represent a random sample of Eastern Finnish people (684 men and 705 women), 57-79 years of age at baseline of the study. Plasma BDNF levels were measured by enzyme-linked immunosorbent assay (ELISA). Cognitive function was evaluated using the Consortium to Establish a Registry for Alzheimer's Disease (CERAD) neuropsychological test battery. Women had a higher mean (+/-SEM) plasma BDNF level than men (1721+/-55vs. 1495+/-54pg/ml, P<0.001). In women, 1 SD decrease in BDNF increased the risk for a low score in Naming Test by 53% (95% CI 1.21-1.92, P<0.001), in Mini-Mental State Examination by 63% (95% CI 1.21-2.20, P=0.001), in Word List Memory by 56% (95% CI 1.08-2.26, P=0.019), in Word List Recall by 50% (95% CI 1.10-2.05, P=0.010), in Word List Saving by 49% (95% CI 1.12-1.99, P=0.007), and in Word List Recognition by 64% (95% CI 1.19-2.25, P=0.002). Data were adjusted for age, education, depression, impaired glucose metabolism, cardiovascular disease, antihypertensive medication, lipid lowering medication, use of sex hormones, smoking, alcohol consumption, storing time of plasma in the freezer and platelet count. BDNF was not associated with cognition in men. Present data suggest that plasma BDNF is a biomarker of impaired memory and general cognitive function in ageing women.     

Creative thinking in adolescents with attention deficit hyperactivity disorder (ADHD).

A widened attentional focus, that is typically associated with ADHD, has been postulated to be accompanied by enhanced creative ability. However, creativity has been only limitedly examined in ADHD. Performance across several creativity measures were investigated in three groups: adolescents with ADHD, those with conduct disorder, and a healthy control sample. The ADHD group exhibited selective cognitive advantages and disadvantages by demonstrating an enhanced ability in overcoming the constraining influence of examples, but a reduced capacity to generate a functional invention during an imagery task. These findings are interpreted with reference to inhibitory control mechanisms and the contextual modulation of creative cognition.     

Fibromyalgie und Leistungseinschränkung

Interdisciplinary guidelines allowed for new quality standards in pain appraisal. Simultaneously, the scientific notion of fibromyalgia changed from a subjectively overvalued malaise to a central disturbance of coping with stress, which is neurobiologically determined. Therefore, in this article a psychosomatics-based guide is given for the socio-medical appraisal of fibromyalgia with reference to the new International Classification for Functioning and Disability (ICF) of the World Health Organization (WHO). As illustration a case study is presented.     

Diagnostic Discrimination of Patients with Different OCD Main Symptom Domains from each Other and from Anxious and Depressive Controls

The extent to which the subscales of multidimensional OCD measures accurately distinguish patients with specific OCD main symptom domains from controls at different cutscores has not yet been examined. Diagnostic accuracy of OCD measures usually is determined by comparing the total scores of heterogeneous OCD samples and controls and therefore may underestimate the measures’ discrimination potential. In the current study, subtype-specific diagnostic accuracy and criterion-related validity of the Obsessive-Compulsive Inventory-Revised (OCI-R) subscales were examined in 327 patients with OCD, anxiety, and/or depressive disorders. All subscales demonstrated good to excellent criterion-related validity and diagnostic accuracy for distinguishing patients with specific OCD main symptom domains from controls. As expected, the single OCI-R subscales lead to more accurate diagnostic decisions than the total scale. Thus, the subscale-specific cutscores significantly improve the OCI-R’s utility for subtype-specific treatment planning and outcome measurement. Furthermore, an alternative classification algorithm distinguishing patients with OCD from controls based on subscale cutscores leads to a better sensitivity, but also to a lower specificity than discrimination based on the total scale cutscore.     

Cannabiskonsum und -missbrauch bei Jugendlichen und jungen Erwachsenen

After a long time of growth current studies on representative samples of adolescents indicate that the number of adolescent cannabis users in Germany is possibly decreasing. However, it may be presumptuous to expect a similar trend concerning the number of clients with cannabis-related disorders. Even if there is in fact a downward trend which is not yet proven, the rapidly growing number of clients presenting with these disorders in recent years cannot be explained by a similar growth in the number of regular cannabis users. Treatment centres should therefore expect a further inreasing number of especially male adolescents and young adults seeking help for problems related to cannabis use. The development, evaluation and implementation of specific treatment options concerning cannabis use disorders will be increasingly needed in the future. Cognitive-behavioral and motivational interventions have been shown to be evidence-based treatments. The paper describes some promising or already successful treatment approaches and related research projects in Germany.     

Goethes Studienkrise, Depression und seine Selbstbehandlungsstrategien

From a present day diagnostic viewpoint Goethe suffered from several episodes of depression beginning with his study crisis. In addition he wrote that he had a tendency towards dysthymic moods. In terms of modern psychotherapeutic procedures the various levels of Goethe’s self-therapy strategies are remarkable: acceptance of helpful bonding and relationships, correction of dysfunctional behavior and modification of pathogenic conceptions and beliefs as well as remembrance, enactment and mentalization of psychodynamic conflicts. Finally at an existential level his salutogenic strategies served to invoke a sence of coherence often threatened in his life. Anxieties, dysthymic moods, lack of self-esteem and existential conflicts were for him not only the reason and motive for realization of his extraordinary artistic potential. For modern psychotherapists and patients it is interesting that the acceptance of dysthymic moods and psychological conflicts and the transformation through relationships, cognitive behavior-oriented and psychodynamic strategies as well as an existential self-effective striving also lead to everyday creativity, i.e. coping with life.     

The Toronto Alexithymia Scale (TAS-20): A measure of general psychological distress

The Toronto Alexithymia Scale (Bagby, R. M., Parker, J. D. A., & Taylor, G. J. (1994). The twenty-item Toronto Alexithymia Scale-I. Item selection and cross-validation of the factor structure. Journal of Psychosomatic Research, 38, 23–32.) is the most commonly used measure of Alexithymia (= difficulties identifying and describing one’s own feelings). Sixty-three persons (34 psychiatric inpatients, 29 healthy controls) first filled in the TAS-20 and were then interviewed about their interpersonal relationships. Two raters coded the emotional experiences that the participants reported during these interviews. Contrary to expectations, participants with higher TAS-20 scores reported more emotions (particularly negative ones), and more different emotions, questioning the validity of the TAS-20 as a measure of Alexithymia. Based on correlation patterns and a joint factor analysis with two well-established measures of psychopathology, it is concluded that the TAS-20 assesses a general psychological distress factor.     

Go no-go performance under psychosocial stress: beneficial effects of implementation intentions

Acute stress has been found to have negative and implementation intentions (IIs) to have positive effects on cognitive performance. This study was the first to examine the effects of IIs on executive action control under acute psychosocial stress. Forty-two male subjects aged 21-39 years were randomly assigned to the Trier Social Stress Test (TSST) versus a rest condition. In addition, the instruction to the executive task (a go no-go task) was manipulated (IIs versus standard instruction). After the stress test, a dual-task procedure including a go no-go task was conducted. The TSST resulted in increases in cortisol response, heart rate and state anxiety compared to the rest condition. Acute stress significantly impaired go no-go performance, but only in the group without IIs. We conclude that under acute stress conditions executive functioning is reduced, but the use of IIs can be an effective strategy to overcome this negative effect.     

How to make your own response boxes: A step-by-step guide for the construction of reliable and inexpensive parallel-port response pads from computer mice

Psychological research is based in large parts on response latencies, which are often registered by keypresses on a standard computer keyboard. Recording response latencies with a standard keyboard is problematic because keypresses are buffered within the keyboard hardware before they are signaled to the computer, adding error variance to the recorded latencies. This can be circumvented by using external response pads connected to the computer's parallel port. In this article, we describe how to build inexpensive, reliable, and easy-to-use response pads with six keys from two standard computer mice that can be connected to the PC's parallel port. We also address the problem of recording data from the parallel port with different software packages under Microsoft's Windows XP.     

On the expression and experience of surprise: no evidence for facial feedback, but evidence for a reverse self-inference effect

Three studies examined the effects of experimentally manipulated surprise expressions on the experience of surprise. Surprise was induced by a sudden, unannounced change of the stimulus presentation during a computerized task. Facial expression was manipulated by leading participants to adopt an expression akin to surprise, or by forcing them to look up steeply to a monitor. The expression manipulations had no intensifying effect on the experience of surprise, whereas manipulations of unexpectedness and mental load had strong effects. In addition, mental load was found to affect beliefs about facial expression, suggesting that the participants used their feelings of surprise to infer their probable facial displays. Path analyses supported this reverse self-inference hypothesis.