Increased levels of conditioned fear and avoidance behavior coincide with changes in phosphorylation of the protein kinase B (AKT) within the amygdala in a mouse model of extremes in trait anxiety

Patients diagnosed for anxiety disorders often display faster acquisition and slower extinction of learned fear. To gain further insights into the mechanisms underlying these phenomenona, we studied conditioned fear in mice originating form a bi-directional selective breeding approach, which is based on elevated plus-maze behavior and results in CD1-derived high (HAB), normal (NAB), and low (LAB) anxiety-related behavior mice. HAB mice displayed pronounced cued-conditioned fear compared to NAB/CD1 and LAB mice that coincided with increased phosphorylation of the protein kinase B (AKT) in the basolateral amygdala 45 min after conditioning. No similar changes were observed after non-associative immediate shock presentations. Fear extinction of recent but not older fear memories was preserved. However, HAB mice were more prone to relapse of conditioned fear with the passage of time. HAB mice also displayed higher levels of contextual fear compared to NAB and LAB mice and exaggerated avoidance following step-down avoidance training. Interestingly, HAB mice showed lower and LAB mice higher levels of acoustic startle responses compared to NAB controls. The increase in arousal observed in LAB mice coincided with the general absence of conditioned freezing. Taken together, our results suggest that the genetic predisposition to high anxiety-related behavior may increase the risk of forming traumatic memories, phobic-like fear and avoidance behavior following aversive encounters, with a clear bias towards passive coping styles. In contrast, genetic predisposition to low anxiety-related and high risk-taking behavior seems to be associated with an increase in active coping styles. Our data imply changes in AKT phosphorylation as a therapeutic target for the prevention of exaggerated fear memories.     

Testing social acoustic memory in rats: Effects of stimulus configuration and long-term memory on the induction of social approach behavior by appetitive 50-kHz ultrasonic vocalizations

Rats emit distinct types of ultrasonic vocalizations (USVs), which serve as situation-dependent affective signals. In appetitive situations, such as rough-and-tumble-play, high-frequency 50-kHz USVs occur, whereas low-frequency 22-kHz USVs can be observed in aversive situations, such as social defeat. USVs serve distinct communicative functions and induce call-specific behavioral responses in the receiver. While aversive 22-kHz USVs serve as alarm calls and induce behavioral inhibition, appetitive 50-kHz USVs have a pro-social communicative function and elicit social approach behavior, supporting the notion that they serve as social contact calls to (re)establish or maintain contact among conspecifics. The aim of the present study was to use the rat's ability to communicate in the ultrasonic range via high-frequency 50-kHz USVs in order to develop a test for social acoustic memory in rats with relevance for human verbal memory. Verbal learning and memory is among the seven cognitive domains identified as commonly deficient in human schizophrenia patients, but particularly difficult to model. We therefore tested whether the induction of social approach behavior by playback of appetitive 50-kHz USVs is dependent on (1) acoustic stimulus configuration and (2) social long-term memory, and whether (3) social long-term memory effects can be blocked by the administration of scopolamine, a muscarinic acetylcholine antagonist producing amnesia. Results show that social approach behavior in response to playback of natural 50-kHz USVs depends on acoustic stimulus configuration and occurs only when sound energy is concentrated to a critical frequency band in the ultrasonic range. Social approach behavior was detected during the first exposure to playback of 50-kHz USVs, whereas no such response was observed during the second exposure 1week later, indicating a stable memory trace. In contrast, when memory formation was blocked by i.p. administration of scopolamine (0.5mg/kg or 1.5mg/kg) immediately after the first exposure, rats displayed social approach behavior during the second exposure as well. Induction of social approach behavior in response to repeated playback of natural 50-kHz USVs may therefore provide a new and rather unique approach for testing social acoustic memory in rats with relevance to human verbal memory.     

Pro-criminal attitudes,intervention, and recidivism

We review the recent research literature on pro-criminal attitudes (PCAs) as a causal factor of recidivism with a focus on studies on the effectiveness of offender treatment programs targeting PCAs to prevent recidivism. The main conclusions that can be derived from the literature are: (1) the evidence supports the hypothesis that PCAs are related to reoffending; (2) most investigated offender treatment programs tend to reduce PCAs, although the general lack of adequate control group designs does not rule out alternative explanations for this reduction; and (3) there is no conclusive empirical evidence that intervention programs designed to reduce PCAs are effective in reducing recidivism. Empirical research in this area lacks the theoretical and methodological rigor to test causal models of the influence of treatment on reducing PCAs, and effects of PCAs on recidivism. Limitations of the empirical evidence are related to inadequate research designs and/or suboptimal data analysis strategies. Recommendations concerning optimized research designs and data analysis strategies that are likely to provide more conclusive evidence on the relation of PCAs, PCA treatment, and recidivism are given.     

The Study of Religions in the Third Reich: A Report on Work in Progress

Why was death considered polluting within classical Greek society when Olympian sacrifice was ubiquitous? Outside the polis the Greeks’ view of the uncultivated or improperly cultivated geography and of their own ‘city-less’ past was just the other way around. Here death represented no pollution whatsoever, while Olympian sacrifice was either absent or not properly performed. Death and life had yet to be separated, as had happened in the proper human realm of the Greek polis. Any reintroduction of either natural death or sacrifice into the ‘city of life’ would consequently negate its very structures. Sacrifice differed exactly through the aspect of control. Acts of sacrifice were therefore used to control the onset of natural death. But why would the Greeks sacrifice also in every other possible context? As the essential human characteristic, mortality pertained to all human creations, including the polis. Left to itself, the polis would wither and die. Through Olympian sacrifice, humans dissolved the structures of the city without ever losing control, thereby introducing the unlimited potential as still found in the primordial state of the uncultivated geography. The structures of the polis were recreated through the proper division of the sacrificial victim.     

Book Review

LOGIC AND ONTOLOGY

PETER SIMONS,Parts: a study in ontology.Oxford , Clarendon Press. 1987. Xiii + 390 PP. £40.

GERHARD HEYER, Generische Kennzeichnungen. Zur Logik und Ontologie generischer Bedeutung. Miinchen und Wien: Philosophia Verlag, 1987. 289pp. DM 138.

GÖDEL STUDIES

GÖDEL , O. TAuSSKY-TODD, S. C. KLEEnE and g. kreisel. Gödel remembered: Salzburg 10-12 July 1983. Edited and foreword by P. Weingartner and L. Schmetterer. Naples: Bibliopolis, 1987. 186 pp, 10 plts. $49.95.

S. G. SHANKER (ed.), Gödel's theorem in focus. London: Croom Helm, 1988. 261 + ix pp. £25.00 (hardback)/£l1.95 (paperback).

SET THEORY AND NUMBER

ALFRED TARSKI and STEVEN GIVANT, A formulization of set theory without variables. (American Mathematical Society Colloquium Publications, volume 41.) Providence,Rhnde Is!and: American Mathematical Society. 1987. 280 pp. $60.00.

J. Bidelow, Thr reality of numbers. A physicalist 's philosophy of mathematics. Oxford: Clarrndon Press. 1988. viii+ 193 pp. £25.

MISCELLANEOUS

PETER J. STEINBERGER, Logic and politics. Hegel's philosophy of' right. New Haven and London: Yale University Press, 1988. xiii + 254 pp. £22.00/$29.00.

MICHELE MALATESTA, La logical primaria. Strumenti per un dialogo tra le Due Culture Napoli and Roma: LER, 1988.193 pp. 25000 lire.     

On the universality of the attribution‐affect model of helping

Although Pilati et al.'s (2014) findings question the strong quantitative universality of the attribution‐affect model of helping, they are consistent with a weak form of quantitative universality, as well as with the qualitative universality of the theory. However, universality is put into question by previous studies revealing significant and sizeable between‐study differences in the strength of the causal paths postulated by the theory. These differences may in part reflect differences in the type of helping situations studied.     

The effect of construal level on risk‐taking

In a series of studies, we examined the influence of people's mind‐set (construal level (CL): abstract versus concrete) on their risk‐taking behavior. We measured differences in CL (study 1, CL as trait) and manipulated CL (studies 1–5, CL as state) with different priming methods, which were unrelated to the dependent variable of risk‐taking behavior (studies 1, 3, 4, and 5: Balloon Analog Risk Task; study 2: Angling Risk Task). In all studies, abstract CL resulted in greater risk‐taking compared with concrete CL, which led to lower risk‐taking. Risky and safe game strategies mediated the CL effect on risk‐taking. A concrete mind‐set increased the safe game strategy, whereas an abstract mind‐set increased the risky game strategy. Furthermore, different potential mediators were explored (i.e., focus on payoffs and probabilities, prevention versus promotion focus, attention to pros versus cons, and mood). A concrete mind‐set increased prevention strategies and a negative mood when compared with an abstract mind‐set. In turn, an abstract mind‐set increased attention to pros (of an action). Copyright © 2014 John Wiley & Sons, Ltd.     

Supportive Social Contexts and Intentions for Civic and Political Participation: An Application of the Theory of Planned Behaviour

We investigated how general social support from family, friends and acquaintances, and community predicted intentions for civic (e.g. volunteering) and political (e.g. petitioning) participation via the constructs specified in the theory of planned behaviour. Participants were young adults living in the former East Germany, a post‐communist region, who were surveyed by telephone in 2010 (N_civic = 695, N_political = 694). Civic participation was perceived more favourably than political participation. Supportive family predicted intentions for civic participation; supportive community services predicted both types of intentions; and supportive friends and acquaintances had no significant effects. The mediating variables were subjective norms and perceived behavioural control, but not attitudes. All effects were controlled for sociodemographic variables, richness of the social network, and past experience of civic and political participation. Findings underscore the role of supportive community in fostering both civic and political participation. Copyright © 2014 John Wiley & Sons, Ltd.     

Perceived Social Support,Perceived Community Functioning,and Civic Participation Across the Life Span: Evidence from the Former East Germany

Are social contexts as important to civic participation in adulthood as they are in adolescence? And does their significance for civic participation vary across adulthood? Using data from a cross-sectional sample of German adults aged 18 to 75 who were surveyed in 2013 by mail, the authors investigated the relationships of perceived family support, perceived support from friends, place attachment, social cohesion, and organizational collective efficacy with three indicators of civic participation. The authors split the sample into four age groups: 18 to 29 (n₁ = 442), 30 to 44 (n₂ = 596), 45 to 59 (n₃ = 1,095), and 60 to 75 (n₄ = 931). Perceived support from family was negatively associated with the breadth (i.e., the number of domains) of civic participation in the youngest group and with future intentions for civic participation in three age groups. Perceived support from friends had positive relationships with the intensity (i.e., frequency) of civic participation and with future intentions at age 30 to 44. Place attachment and organizational collective efficacy were positively related to all indicators of civic participation, and some of these associations held across age groups. In contrast, social cohesion had no significant effects. The authors discuss implications for fostering civic participation across adulthood.