Vegetative state: efforts to curb misdiagnosis

Media reports on the case of Rom Houben have constituted a new reminder of the risks of misdiagnosis with cases with apparent vegetative state, particularly when following the clinical consensus of the care team as diagnostic criterion. Systematic use of behavioral and non-behavioral assessment strategies (e.g., behavioral scales, event-related potentials, and neuro-imaging) may help reduce the aforementioned risks. A new learning assessment strategy could also be considered part of the assessment to extend the evaluation process. Signs of learning might be viewed as forms of concrete knowledge representing a basic level of non-reflective consciousness.     

Paradoxical cross-over due to attention to high or low spatial frequencies

The mechanisms underlying the right hemisphere's dominance for spatial and attentional functions lacks a comprehensively explanation. For example, perceptual biases, as observed in line bisection and related tasks, might be caused by an attentional asymmetry or by perceptual processes such as a specialization of the left and right hemisphere for high and low spatial frequencies (SFs), respectively. Here we used the gratingscales task to measure perceptual bias in SF judgements, and we cued participants' attention either to high or low SFs. Participants showed a leftward bias when comparing the high SF components of the stimulus, and a rightward bias when comparing the low SF components-opposite to what would be expected from a hemispheric lateralization for SFs. Two control experiments used different strategies to manipulate the width of the attentional window. However, we observed no influence on perceptual bias, thus ruling out the possibility that the results in Experiment 1 were due to differences in attentional window size. These data support the idea of an attentional asymmetry underlying perceptual bias. Our results provide novel support for the role of attentional asymmetry in perceptual biases.     

Predicting General Well-Being From Emotional Intelligence and Three Broad Personality Traits

This paper examined the joint predictive effects of trait emotional intelligence (trait-EI), Extraversion, Conscientiousness, and Neuroticism on 2 facets of general well-being and job satisfaction. An employed community sample of 123 individuals from the Indian subcontinent participated in the study, and completed measures of the five-factor model of personality, trait-EI, job satisfaction, and general well-being facets worn-out and up-tight . Trait-EI was related but distinct from the 3 personality variables. Trait-EI demonstrated the strongest correlation with job satisfaction, but predicted general well-being no better than Neuroticism. In regression analyses, trait-EI predicted between 6% and 9% additional variance in the well-being criteria, beyond the 3 personality traits. It was concluded that trait-EI may be useful in examining dispositional influences on psychological well-being.     

Ceftriaxone rescues hippocampal neurons from excitotoxicity and enhances memory retrieval in chronic hypobaric hypoxia

Exposure to high altitude is known to cause impairment in cognitive functions in sojourners. The molecular events leading to this behavioral manifestation, however, still remain an enigma. The present study aims at exploring the nature of memory impairment occurring on chronic exposure to hypobaric hypoxia and the possible role of glutamate in mediating it. Increased ionotropic receptor stimulation by glutamate under hypobaric hypoxic conditions could lead to calcium mediated excitotoxic cell death resulting in impaired cognitive functions. Since glutamate is cleared from the synapse by the Glial Glutamate Transporter, upregulation of the transporter can be a good strategy in preventing excitotoxic cell death. Considering previous reports on upregulation of the expression of Glial Glutamate Transporter on ceftriaxone administration, the therapeutic potential of ceftriaxone in ameliorating hypobaric hypoxia induced memory impairment was investigated in male Sprague Dawley rats. Exposure to hypobaric hypoxia equivalent to an altitude of 7600 m for 14 days lead to oxidative stress, chromatin condensation and neuronal degeneration in the hippocampus. This was accompanied by delayed memory retrieval as evident from increased latency and pathlength in Morris Water Maze. Administration of ceftriaxone at a dose of 200 mg/kg for 7 days and 14 days during the exposure on the other hand improved the performance of rats in the water maze along with decreased oxidative stress and enhanced neuronal survival when compared to hypoxic group without drug administration. An increased expression of Glial Glutamate Transporter was also observed following drug administration indicating faster clearance of glutamate from the synapse. The present study not only brings to light the effect of longer duration of exposure to hypobaric hypoxia on the memory functions, but also indicates the pivotal role played by glutamate in mediating excitotoxic neuronal degeneration at high altitude. The therapeutic potential of ceftriaxone in providing neuroprotection in excitotoxic conditions by increasing Glial Glutamate Transporter expression and thereby enhancing glutamate uptake from the synapse has also been explored.     

Microswitch-based programs for persons with multiple disabilities: an overview of some recent developments

Persons with multiple disabilities are often unable to interact with their environment due to their limited response repertoire. Microswitch programs are designed to help them control environmental events, generally preferred stimulation, through simple (feasible) responses. To make microswitch programs a more widely usable and relevant resource for intervention with these persons, a number of new developments were pursued in recent years. This paper examines three of those developments as specifically addressed in our research activity, namely, (a) assessment of new, nontypical responses and matching microswitches, (b) fostering of multiple responses and exercise of choice, and (c) targeting of habilitative and clinical (therapeutic) objectives. The encouraging outcomes of these developments are reviewed in relation to their potentially wide implications for daily practice and the need of additional developments in the area.     

Views of Employee Participation, Higher Order Needs, Altruism, Pride in Craftsmanship, and Collectivism: Implications for Organizational Practice and Public Policy

Using a sample of 749 individuals, we examine the correlation of views of employee participation and higher order needs, altruism, pride in craftsmanship, and collectivism. Structural equation modeling (accounting for measurement errors) shows that views of employee participation are correlated positively with higher order needs, altruism, pride in craftsmanship, and collectivism. Our model also shows equivalency across 3 different age groups. Implications of our results for organizational practice and public policy are discussed.     

The Process of Transcending a Traumatic Childhood

This study used a qualitative, exploratory approach to develop a conceptual framework that illustrated the process by which spirituality emerged as one of the processes that helped people transcend a traumatic childhood. Ninety people described how they survived and transcended the difficult time. This article outlines the stages of the developmental process that culminated for many in a deeper spiritual awareness and how this helped them in their process of transcending. These findings have implications for marriage and family therapists, clergy, and others in the helping professions in providing therapy, resources, and support for those who have experienced difficult childhoods.     

What matters most? The relative role of mentoring and career capital in career success

This study used a career capital framework to compare the relative role of mentoring and three other forms of career capital (human, agentic, and developmental network capital) in predicting career success. Using a three-wave longitudinal design we found that mentoring added value, above and beyond the other forms of career capital, in predicting promotions and advancement expectations. However, although mentoring mattered for career success, it represented just a part of a constellation of career resources that are embedded within individuals and their relationships. Implications for future research are discussed.