Hippocampal PKA/CREB pathway is involved in the improvement of memory induced by spermidine in rats

Spermidine (SPD) is an endogenous polyamine that modulates N-methyl-D-aspartate (NMDA) receptor function, and has been reported to facilitate memory formation. In the current study we determined whether or not the PKA/CREB signaling pathway is involved in SPD-induced facilitation of memory of inhibitory avoidance task in adult rats. The post-training administration of the cAMP-dependent protein kinase (PKA) inhibitor, N-[2-bromocinnamylamino)ethyl]-5-isoquinoline sulfonamide [H-89, 0.5 ρmol intrahippocampal (ih)] or the antagonist of the NMDA receptor polyamine-binding site (arcaine, 0.02 nmol ih) with SPD (0.2 nmol ih) prevented memory improvement induced by SPD. Intrahippocampal administration of SPD (0.2 nmol) facilitated PKA and cAMP response element-binding protein (CREB) phosphorylation in the hippocampus 180 min, but not 30 min, after administration, and increased translocation of the catalytic subunit of PKA into the nucleus. Arcaine (0.02 nmol) and H-89 (0.5 ρmol) prevented the stimulatory effect of SPD on PKA and CREB phosphorylation. These results suggest that memory enhancement induced by the ih administration of SPD involves the PKA/CREB pathways in rats.     

Third International Conference on Spatial Cognition: “Dynamics in Spatial Interactions”. Rome - Perugia, Italy: September 12th–15th 2006. www.icsc2006.org - committee@icsc2006.org

Call for Papers

Third International Conference on Spatial Cognition: “Dynamics in Spatial Interactions”. Rome - Perugia, Italy: September 12th–15th 2006. www.icsc2006.org - committee@icsc2006.org     

Self-definition and self-defense: Jewish racial identity in nineteenth-century France

This article examines how and why French Jews began to speak of themselves as a race. Though we often assume that Jewish racial identity was an invention of anti-Semites in the 1880s, Jewish publicists had in fact adopted this language as early as the 1820s. Far from unwittingly appropriating the language of their detractors, Jews borrowed the language of race from scholars neutral or sympathetic to their cause in ways that made sense in light of their larger strategies of self-defense. The scholars who pioneered modern race theory were not the late nineteenth-century Social Darwinists; they were romantic historians like the Thierrys and Michelet, who saw France as a nation composed of a plurality of peoples who had come together over time to form a unified nation. Race thus provided a framework for understanding difference as legitimate, useful and dignified at a moment when anti-Jewish publicists attacked Jews as anti-social and immoral people who brought only harm to France. Looking at what French Jews borrowed from these early historians allows us to see the interconnections between Jewish self-defense and Jewish self-definition. In seeking to guarantee their rights and social status, French Jews appropriated new terms of understanding who they were.     

Sexual risk as an outcome of social oppression: data from a probability sample of Latino gay men in three U.S. cities

Based on data from a probability sample of 912 Latino gay men in 3 U.S. cities, a multivariate model of sexual risk was tested, including experiences of homophobia, racism, and poverty as predictors. Participants reported multiple instances of verbal and physical abuse, rude mistreatment, and discrimination on account of their sexual orientation and their race or ethnicity. Many reported experiences of poverty, such as inability to pay for basic necessities of food or shelter. Men who reported more instances of social discrimination and financial hardship were more psychologically distressed and more likely to participate in "difficult" sexual situations, as predicted. Participation in difficult sexual situations mediates the effects of social oppression and psychological distress on sexual risk behavior.     

About the Contributors

Biography

About the Contributors     

Methylphenidate Does Not Modify the Impact of Response Frequency or Stimulus Sequence on Performance and Event-Related Potentials of Children with Attention Deficit Hyperactivity Disorder

Twenty-six children with attention deficit/hyperactivity disorder (ADHD) participated in a double-blind trial consisting of 2 consecutive weeks each of placebo and methylphenidate (M = 26.92 mg/day = 0.78 mg/kg/day). As expected, stimulant therapy resulted in moderate weight loss, increased somatic complaints, and teacher and parent reports of reduced inattentiveness, aggression, and oppositionality. In both phases of the trial, patients were tested in a choice reaction time task assessing two aspects of the task that presumably affect response selection: response frequency (ratio of targets/nontargets = 25/75 vs. 50/50) and stimulus sequence (alternations vs. repetitions). Both manipulations yielded expected results on performance and event-related potentials (ERPs). Stimulant treatment increased accuracy and speed among younger children and curtailed variability of reaction time for the sample as a whole. However, methylphenidate did not affect ERPs. In combination, the results imply that the enhancement of performance by methylphenidate does not involve the demands of response selection examined in this study.