Methylphenidate speeds evaluation processes of Attention Deficit Disorder adolescents during a continuous performance test

Fortysix Attention Deficit Disorder (ADD) adolescents took a Continuous Performance Test (CPT) under placebo and methylphenidate (35.33 mg/day). The task required pressing one button for targets (p=133),and another button for nontargets. Subjects displayed a strong bias to make the more frequent negative response before completely evaluating stimuli. Consistent with this assumption, subjects responded faster (by an average of 87 ms) to nontargets than to targets. Methylphenidate increased accuracy and speeded reaction times (RTs) to targets. The drug also increased the amplitude of the P3b component of the eventrelated potential for nontargets and shortened the latency of P3b for both targets and nontargets. These results suggest increased capacity allocation to and faster evaluation of task stimuli. Finally, the stimulant lengthened relative motor processing time (RT-P3b latency) for nontargets, a finding implying that response processing was accomplished with the benefit of earlier completion of evaluation processes for these stimuli.Portions of these findings were reported at the meeting of the Society for Research in Child and Adolescent Psychopathology, Costa Mesa, California, January 24–26, 1990. This research was supported by NIMH grant MH38118 to the first author. We thank the late Helen Pollock and the University of Rochester's Strong Memorial Hospital Pharmacy Manufacturing Department for their help.     

Memory-Enhancing Treatments Do Not Reverse the Impairment of Inhibitory Avoidance Retention Induced by NMDA Receptor Blockade

The aim of the present research was to verify whether the impairment of retention induced by the N-methyl-d-aspartate (NMDA) receptor blocker (+)-10,11-dihydro-5-methyl-5H-dibenzo[a,d]cycloheptene-5,10 imine (MK-801) can be reversed by memory-enhancing treatments. Adult female Wistar rats were trained and tested in a step-down inhibitory avoidance task (0.3-mA foot shock, 24-h training-test interval). Animals were given an ip injection of saline (SAL) or MK-801 (0.0625 mg/kg) 30 minutes before training, and an ip injection of SAL, epinephrine (EPI) (25 microg/kg), the opioid receptor antagonist naloxone (NAL) (0.4 mg/kg), the glucocorticoid receptor agonist dexamethasone (DEX) (0.3 mg/kg), or glucose (GLU) (320 mg/kg) immediately after training. There was an impairment of inhibitory avoidance retention in the MK-801-SAL, MK-801-EPI, MK-801-NAL, MK-801-DEX, and MK-801-GLU groups. There was an enhancement of retention in the SAL-EPI, SAL-NAL, SAL-DEX, and SAL-GLU groups. A control experiment showed that the amnestic effects of MK-801 could not be attributed to decreased reactivity to the foot shock. The results suggest that memory-enhancing treatments directed at modulatory mechanisms do not reverse the memory impairment induced by NMDA receptor blockade.     

Two Conceptions of Response-dependence

The traditional conception of response-dependence isinadequate because it cannot account for all intuitivecases of response-dependence. In particular, it is unableto account for the response-dependence of (aesthetic, moral, epistemic ...) values. I therefore propose tosupplement the traditional conception with an alternativeone. My claim is that only a combination of the twoconceptions is able to account for all intuitivecases of response-dependence.     

Basic dimensions of work design: new inputs to functional flexibility

Although a lot of research has been developed during the last century in the field of human work design, the results seem to be unsatisfactory. Nowadays, there is renewed interest in this field but it is not producing any new results. This is the main reason why, in our investigation, we have tried to determine the real variables that truly affect the human work design. We have carried out two empirical researches involving 660 and 310 companies, obtaining from both exactly the same results, four factors that confirm the conclusions reached in previous research: demand-adaptation, flexibility-polyvalence, improvement-autonomy and conciliation-participation. We can add that these factors are independent from the environment and the type of technology used by the companies, which does not occur if the size of the enterprise is taken into account.     

Contributions and novelties from Functional Analytic Psychotherapy

Functional Analytic Psychotherapy is based on the principles of radical behaviourism. It emphasises the impact of events occurring during therapeutic sessions, the therapist-client interaction context, functional equivalence of environments, natural reinforcement, and shaping by the therapist. Functional Analytic Psychotherapy makes use of both the basic principles of behaviour analysis: individual functional assessment and application of in vivo treatment. This paper analyses novelties and new contributions of this therapy. New contributions are classified in various categories: integration with other psychotherapies, improvement of therapeutic skills, methods for evaluation and data recording in therapy, its application to several clinical problems, and studies of its efficacy.     

Nietzsche and l’élan technique: Technics,life, and the production of time

Abstract In this paper we examine Nietzsche’s relation to the life sciences of his time and to Darwinism in particular, arguing that his account of the will to power in terms of technics eschews three metaphysical prejudices, hylemorphism, utilitarianism, and teleological thinking. Telescoping some of Nietzsche’s pronouncements on the will to power with a Bergsonian lens, our reading of the will to power, as an operation productive of time, the future or life, offers an alternative to Heidegger’s. Rather than being reducible to a technics of domination or mastery, the will to power, we argue, is best interpreted as a technics of material forces that recasts all things past and future, near and far, moment by moment.     

Go/no‐go procedure with compound stimuli with children with autism

The go/no‐go with compound stimuli is an alternative to matching‐to‐sample to produce conditional and emergent relations in adults. The aim of this study was to evaluate the effectiveness of this procedure with two children diagnosed with autism. We trained and tested participants to respond to conditional relations among arbitrary stimuli using the go/no‐go procedure. Both learned all the trained conditional relations without developing response bias or responding to no‐go trials. Participants demonstrated performance consistent with symmetry, but not equivalence.     

Uphill and Downhill in a Flat World: The Conceptual Topography of the Yupno House

Speakers of many languages around the world rely on body‐based contrasts (e.g., left/right ) for spatial communication and cognition. Speakers of Yupno, a language of Papua New Guinea's mountainous interior, rely instead on an environment‐based uphill/downhill contrast. Body‐based contrasts are as easy to use indoors as outdoors, but environment‐based contrasts may not be. Do Yupno speakers still use uphill/downhill contrasts indoors and, if so, how? We report three studies on spatial communication within the Yupno house. Even in this flat world, uphill/downhill contrasts are pervasive. However, the terms are not used according to the slopes beyond the house's walls, as reported in other groups. Instead, the house is treated as a microworld, with a “conceptual topography” that is strikingly reminiscent of the physical topography of the Yupno valley. The phenomenon illustrates some of the distinctive properties of environment‐based reference systems, as well as the universal power and plasticity of spatial contrasts.