Public Trust in Genomic Risk Assessment for Type 2 Diabetes Mellitus

Patient trust in personal medical information is critical to increasing adherence to physician recommendations and medications. One of the anticipated benefits of learning of one’s genomic risk for common diseases is the increased adoption of screening, preventive care and lifestyle changes. However, the equivocal results thus far reported of the positive impact of knowledge of genomic risk on behavior change may be due to lack of patients’ trust in the results. As part of a clinical study to compare two methods of communication of genomic risk results for Type 2 diabetes mellitus (T2DM), we assessed patients’ trust and preferred methods of delivery of genomic risk information. A total of 300 participants recruited from the general public in Durham, NC were randomized to receive their genomic risk for T2DM in-person from a genetic counselor or online through the testing company’s web-site. Participants completed a baseline survey and three follow-up surveys after receiving results. Overall, participants reported high levels of trust in the test results. Participants who received their results in-person from the genetic counselor were significantly more likely to trust their results than those who reviewed their results on-line (p?=?0.005). There was not a statistically significant difference in levels of trust among participants with increased genetic risk, as compared to other those with decreased or same as population risk (p?=?0.1154). In the event they undergo genomic risk testing again, 55 % of participants overall indicated they would prefer to receive their results online compared to 28 % that would prefer to receive future results in-person. Of those participants preferring to receive results online, 77 % indicated they would prefer to have the option to speak to someone if they had questions with the online results (compared to accessing results online without the option of professional consultation). This is the first study to assess satisfaction with genomic risk testing by the method of delivery of the test result. The higher rate of trust in results delivered in-person suggests that online access reports may not result in serious consideration of results and lack of adoption of recommended preventive recommendations.     

An Assessment of Time Involved in Pre-test Case Review and Counseling for a Whole Genome Sequencing Clinical Research Program

Whole genome sequencing (WGS) is being used for evaluation of individuals with undiagnosed disease of suspected genetic origin. Implementing WGS into clinical practice will place an increased burden upon care teams with regard to pre-test patient education and counseling about results. To quantitate the time needed for appropriate pre-test evaluation of participants in WGS testing, we documented the time spent by our clinical research group on various activities related to program preparation, participant screening, and consent prior to WGS. Participants were children or young adults with autism, intellectual or developmental disability, and/or congenital anomalies, who have remained undiagnosed despite previous evaluation, and their biologic parents. Results showed that significant time was spent in securing allocation of clinical research space to counsel participants and families, and in acquisition and review of participant’s medical records. Pre-enrollment chart review identified two individuals with existing diagnoses resulting in savings of $30,000 for the genome sequencing alone, as well as saving hours of personnel time for genome interpretation and communication of WGS results. New WGS programs should plan for costs associated with additional pre-test administrative planning and patient evaluation time that will be required to provide high quality care.     

Minding the ($500,000) Gap: Accounting for the Gender-Driven Gap in Executive Severance Agreements

Journal of Business and Psychology - As the number of women in leadership positions continues to rise, it is important to closely examine the gender pay gap at the executive level. Prior studies...     

It’s a Matter of Organizational Pride: How Perceptions of Organizational Virtuousness and Competence Affect Employee Behaviors

Journal of Business and Psychology - Companies often discuss the importance of organizational pride and what they believe leads to it, yet research on this topic in the organizational sciences has...     

Electrodermal Activity Moderates Sleep-Behavior Associations in Children with Autism Spectrum Disorder

Research on Child and Adolescent Psychopathology - Relative to children without autism spectrum disorder (ASD), children with ASD experience elevated sleep problems that can contribute to...     

Personality predicts innovation and social learning in children: Implications for cultural evolution

Innovation and social learning are the pillars of cultural evolution, allowing cultural behaviours to cumulatively advance over generations. Yet, little is known about individual differences in the use of social and asocial information. We examined whether personality influenced 7-11-year-old children's (N = 282) propensity to elect to observe others first or independently generate solutions to novel problems. Conscientiousness was associated with electing for no demonstrations, while agreeableness was associated with opting for demonstrations. For children receiving demonstrations, openness to experience consistently predicted deviation from observed methods. Children who opted for no demonstrations were also more likely than those opting for demonstrations to exhibit tool manufacture on an innovation challenge and displayed higher creativity, as measured by an alternate uses task. These results highlight how new cultural traditions emerge, establish and advance by identifying which individuals generate new cultural variants in populations and which are influential in the diffusion of these variants, and help reduce the apparent tension within the ‘ratchet’ of cumulative culture.     

Driving it Home: How Workplace Emotional Labor Harms Employee Home Life

To date, the majority of research on emotional labor has focused on outcomes that occur in the workplace. However, research has yet to consider the possibility that the daily effects of emotional labor spill over to life outside of work, even though a large body of literature examining the spillover from work life to home life indicates that work experiences influence employees after they leave the workplace. Accordingly, we examined the influence of day‐to‐day surface acting on 3 types of theoretically derived stress outcomes experienced at home: emotional exhaustion, work‐to‐family conflict, and insomnia. In an experience sampling field study of 78 bus drivers, we found that daily surface acting was connected to increases in each of the outcomes noted above. Moreover, surface acting had an indirect effect on emotional exhaustion and insomnia via state anxiety.     

Callous-Unemotional Traits and Antisocial Behavior among Adolescents: the Role of Self-Serving Cognitions

Self-serving cognitions and callous-unemotional traits play important roles in adolescent antisocial behavior. The objective of this study was to cross-sectionally explore the mediating role of self-serving cognitions in the relationship between callous-unemotional traits and antisocial behavior. A sample of 972 high-school students completed self-report questionnaires assessing callous-unemotional traits, self-serving cognitive distortions and antisocial behavior. Two competing models exploring indirect effects accounting for the relationships between self-serving cognitive distortions, callous-unemotional traits and antisocial behaviors were tested. Both models revealed significant indirect effects, suggesting both pathways are possible. Gender was found to moderate these models. These findings suggest the importance of targeting self-serving cognitions in therapeutic interventions and increase our understanding of the role of self-serving cognitions in antisocial behavior.     

Reducing reliance on inaccurate information

People learn from the texts that they read, but sometimes what they read is wrong. Previous research has demonstrated that individuals encode even obvious inaccuracies, at times relying on the misinformation to complete postreading tasks. In the present study, we investigated whether the influence of inaccurate information might be reduced by encouraging the retrieval of accurate knowledge. Participants read an extended text that contained both accurate and inaccurate assertions, after which they evaluated the validity of statements associated with those assertions. In general, participants made more mistakes in their evaluations of statements after having read inaccurate as compared to accurate assertions, offering evidence of the influence of misinformation. However, when participants were tasked with correcting inaccuracies during reading, their mistakes were substantially reduced. Encouraging the retrieval of accurate knowledge during reading can reduce the influence of misinformation. These findings are discussed with respect to the contributions of episodic traces and prior knowledge on learning, as well as to the conditions that support successful comprehension.