Hemispheric involvement in shadowing vs. interpretation: a time-sharing study of simultaneous interpreters with matched bilingual and monolingual controls

A time-sharing study used shadowing and interpretation/paraphrasing tasks to evaluate lateralization in professional interpreters individually matched to bilingual and monolingual controls. A two-step multivariate general linear model procedure was used to determine lateralized effects and extent of disruption produced by the tasks. Results revealed the monolingual group to be left lateralized for both tasks, but the two bilingual groups were lateralized in the LH only for shadowing. The monolingual group was significantly different from the bilingual groups in the pattern of hand asymmetry for interpretation/paraphrasing. The findings replicate outcomes of prior repeated measures analysis of variance procedures on percentage of change scores. However, new information is added by the more refined analysis. The findings are also discussed in terms of previous laterality studies using similar tasks and subject samples.     

Ethanol-mediated taste aversions and state-dependency in preweanling (16-day-old) rats

Requirements for conditioning of an ethanol-mediated taste aversion in 16-day-old rat pups were examined. Experiment 1 demonstrated that preweanling rats are capable of acquiring, in two trials, an aversion to a 15% sucrose solution when followed by intragastric intubation of a 1.2 g/kg dose of 17% v/v ethanol, but not when followed by a 0.4 g/kg dose. Comparison was with control animals given sucrose followed by an equivalent volume isocaloric Half and Half. When the 0.4 g/kg dose of ethanol preceded sucrose presentation by 30 min (Experiment 2), the aversion was learned, suggesting that the effective delay between the sucrose and the critical consequences of the ethanol had been too long with the former procedure. Expression of the sucrose aversion required, however, the reinstatement of the context of intoxication--state-dependent retention. Finally, the results of Experiment 3B indicated that, in addition to the association between the sucrose and the aversive consequences of alcohol intoxication, the orosensory cues resulting from alcohol's direct elimination, via such processes as respiration and salivation, became associated with the appetitive properties of the sucrose. This was evidenced by a conditioned increase in preference for ethanol odor. Possible age-related differences in the ability to associate stimuli with alcohol's unconditioned consequences, and in state dependency are discussed.     

Performance objectives in the stance phase of human pathological walking

Permanent disruption of aspects of a highly learned skill such as walking force adaptations to occur to the movement. Firstly the body must determine what factors will guide the formation of the new walking pattern, and secondly that new movement pattern must be learned. Frequently the questionable assumption is made that the performance objectives of the new skill are the same as the original. This work used non-linear optimal control and multiple segment simulation to evaluate the ability of several possible objective functions to predict pathological walking patterns. These predictions were then also compared to the results from normal walking. Preliminary results indicate the performance objectives of pathological gaits may be quite different from those of normals. Some support was also provided for the existence of simultaneous multiple performance objectives in complex movements.     

Efficacy of behavioral management and patient education on vascular access cleansing compliance in hemodialysis patients

Compared four treatment conditions to test their ability to enhance compliance with vascular access cleansing (VAC) procedures in a group of 56 hemodialysis patients. The conditions were patient education, behavioral management with monetary incentive, patient education/behavioral management, and attention control. Behavioral observers rated VAC behavior at pretreatment, posttreatment 1-month follow-up, and 1-year follow-up. Knowledge of VAC procedures was also assessed via a questionnaire at pretreatment and posttreatment. Data were analyzed using repeated-measures multivariate analyses of variance. Results indicated that the patients in the education/behavioral, behavioral, and education groups gave significantly more correct answers on our VAC knowledge questionnaires at posttreatment than did patients in the attention control group. Further, patients in the education/behavioral and behavioral groups completed significantly more VAC steps at posttreatment and 1-month follow-up than did patients in the education group and in the attention control group. Differences were not maintained at 1-year follow-up, although more than 50% of the patients were lost to follow-up. Implications of the present findings for behavioral and educational interventions are discussed.     

Inquiry into intentional systems I: Issues in ecological physics

Summary The role of intention in guiding the behavior of goal-directed systems is a problem that continues to challenge behavioral science. While it is generally agreed that intentional systems must be consistent with the laws of physics, there are many obvious differences between inanimate, physical systems and sentient, intentional systems. This suggests that there must be constraints over and above those of physics that govern goal-directed behavior. In this paper it is suggested that generic properties of self-organizing mechanisms may play a central role in the origin and evolution of intentional constraints. The properties of self-organizing systems are first introduced in the context of simple physical systems and then extended to a complex (biological) system. Whereas behavior of an inanimate physical system is lawfully determined by force fields, behavior of an animate biological system is lawfully specified by information fields. Biological systems are distinguished from simple physical systems in terms of their ubiquitous use of information fields as special (biological and psychological, social, etc.) boundary conditions on classical laws. Unlike classical constraints (boundary conditions), informational constraints can vary with time and state of the system. Because of the nonstationarity of the boundary conditions, the dynamic of the system can follow a complex trajectory that is organized by a set of spatially and temporally distributed equilibrium points or regions. It is suggested that this equilibrium set and the laws that govern its transformation define a minimal requirement for an intentional system. One of the benefits of such an approach is that it suggests a realist account for the origin of semantic predicates, thereby providing a basis for the development of a theory of symbolic dynamics. Therefore, the principles of self-organization provide a comprehensive basis for investigating intentional systems by suggesting how it is that intentions arise, and by providing a lawful basis for intentional behavior that reveals how organisms become and remain lawfully informed in the pursuit of their goals.     

A review of patient outcomes in pharmacological studies from the psychiatric literature, 1966–1993

A literature search was conducted on studies of new drugs used with patients with schizophrenia reported by U.S. and non-U.S. researchers from 1966–1993, yielding 41 U.S., and a total of 24 other non-U.S. studies, among them 11 British studies. Results of the U.S. and non-U.S. studies were pooled separately and compared. Among several comparable conditions discussed, the lack of any data on suicides in the U.S. studies was observed. For a second statistical analysis of suicide rates ‘person-years’ were calculated to adjust for differing washout durations. The results obtained include findings that the percentage of patients relapsing in U.S. studies was slightly lower (37.9%) than in non-U.S. studies (46%); the percentage of patients dropping out in U.S. studies (10.5%) was higher than in non-U.S. studies (7.6%); known location of dropout patients in U.S. studies was 1.7%, compared to 2.6% in non-U.S. studies. The most interesting finding was that no suicides were reported in U.S. studies, compared to 0.6% of patients reported in British studies. Some U.S. studies used ‘challenge doses’, such as amphetamines or L-dopa; no non-U.S. studies reported their use. Compared to U.S. studies, those by non-U.S., and particularly British, researchers appeared to report adverse events in their studies. ‘Challenge’ drugs were not used; suicides were reported. It is estimated that the probability that no patients suicided who participated in the U.S. is small—one in 500.     

Use and misuse of metrics in research evaluation

This paper addresses some critical issues in the applicability of quantitative performance measures (including bibliometric, economic, and co-occurrence measures) to the assessment of basic research. The strengths and weaknesses of metrics applied as research performance measures are examined. It is concluded that metrics have a useful role to play in the evaluation of research. Each metric employed, whether bibliometric, economic, co-occurrence, or others, brings a new dimension of potential insight to the complex problem of research assessment. However, when used in a stand-alone mode, metrics can be easily misinterpreted and result in misleading conclusions. Metrics should be an integral part of a more comprehensive approach to research evaluation, in which the leading role is assumed by expert peer review. Under this structure, the reviewers must be broadly constituted, so that the technical correctness of the research approaches being taken (doing the job right) can be evaluated by technical experts and the correctness of the research target (doing the right job) can be evaluated as well. This comprehensive approach insures quality in the implementation of existing research paradigms and allows the introduction of revolutionary new research paradigms as well. The views contained in this paper are solely those of the author and do not represent the views of the Department of the Navy. Ronald Kostoff received a Ph.D. from Princeton University, performed technical and economic research at Bell Laboratories, managed energy programs at U.S. Department of Energy, was Director of Technical Assessment at the Office of Naval Research for many years and presently manages the Navy’s In-House Laboratory Independent Research Program.     

Spline smoothing with model-based penalties

Nonparametric regression techniques, which estimate functions directly from noisy data rather than relying on specific parametric models, now play a central role in statistical analysis. We can improve the efficiency and other aspects of a nonparametric curve estimate by using prior knowledge about general features of the curve in the smoothing process. Spline smoothing is extended in this paper to express this prior knowledge in the form of a linear differential operator that annihilates a specified parametric model for the data. Roughness in the fitted function is defined in terms of the integrated square of this operator applied to the fitted function. A fastO(n) algorithm is outlined for this smart smoothing process. Illustrations are provided of where this technique proves useful.