Gender-Moderated Dorsolateral Prefrontal Reductions in 22q11.2 Deletion Syndrome: Implications for Risk for Schizophrenia

To investigate the impact of the microdeletion on morphology of the prefrontal cortex in 22q11.2 Deletion Syndrome (22q11.2 DS), high-resolution, anatomic magnetic resonance imaging was performed on 19 children and adolescents with 22q11.2 DS (11 females, 8 males) and 18 unaffected controls (10 females, 8 males). Tissue volumes of the dorsolateral, dorsomedial, orbitolateral, and orbitomedial prefrontal cortex were measured. Tasks of executive function and working memory were administered to investigate the association between anatomy and function. Whole brain volume and frontal lobe tissue volume were preserved in girls but reduced in boys with 22q11.2 DS relative to age-matched controls. Dorsolateral prefrontal cortex (DLPFC) volumes were reduced in participants with 22q11.2 DS, although the gender-by-diagnosis effect found for frontal lobe was not as robust for DLPFC. DLPFC volumes were associated with performance on tasks of planning and emotional facial recognition. Longitudinal studies are needed to clarify whether gender differences in frontal lobe and DLPFC persist with development, and whether the volumes of the DLPFC are associated with eventual deterioration in adaptive/psychosocial function that may presage the onset of schizophrenia, for which individuals with 22q11.2 DS are at a disproportionately high risk.     

The Concept of Responsibility: Introduction and Translation

Adrian Hastings, The Church in Africa 1450–1950. Oxford, Clarendon Press, 1994, xiv+706 pp., 8 maps, $ 45.00 (paperback) ISBN 0 19 826399 6.

Elizabeth Isichei, A History of Christianity in Africa. Grand Rapids, MI, Eerdmans, 1995, xi+420 pp., $ 24.00 ISBN 0 8028 08433.

Paul Giord (ed.), The Christian Churches and the Democratisation of Africa. Studies of Religion in Africa: Supplements to the Journal of Religion in Africa, No. 12. Leiden, Brill, 1995, xi+301 pp., $ 101.50 ISBN 9004103244.

Paul Giord, African Christianity: Its Public Role. Bloomington, Indiana University Press, 1998, viii+368 pp., $ 39.95 (hardback) ISBN 0 253 33417 9, $ 22.95 (paperback) ISBN 0 253 21204 9.

Kwame Bediako, Christianity in Africa: The Renewal of a Non-Western Religion. Edinburgh, Edinburgh University Press, 1995, xii+276 pp., £18.00 (paperback) ISBN 0 7486 0635 4; New York, Orbis Books, 1995, $ 25.00 (paperback) ISBN 1570750483.     

Doing What Comes Naturally: Recent Work on Thomas Aquinas and the New Natural Law Theory

John Finnis, Aquinas: Moral, Political, and Legal Theory. Oxford, Oxford University Press, 1998, xxi+385 pp., $55.00 (hardback) ISBN 0 19 87808 42, $18.95 (paperback) ISBN 0 19 878085 0.

Robert P. George, In Defense of Natural Law. Oxford, Oxford University Press, 1999, 343 pp., $65.00 (hardback) ISBN 0 19 82677 11, $19.95 (paperback) ISBN 0 19 92429 92     

A comparison of computer and questionnaire methods of history-taking in a genito-urinary clinic

Abstract

Information on the medical history and symptomatology of 69 patients presenting at a genito-urinary (GU) clinic was obtained either by a computerized interview or a paper questionnaire and the results compared. A comparison was also made between these methods and notes taken during a standard physician interview. Significantly more symptoms were elicited by the computer than the paper questionnaire. Both methods also elicited significantly more symptoms than were recorded by the physician. The patients reported having previously attended a GU clinic more often to the computer than to the physician whereas the questionnaire was no different from the physician. The results indicate that computers can be used satisfactorily to facilitate medical history- taking in GU clinics and may result in a more complete profile of symptoms than either written questionnaire or physician interview.     

Personal mastery predicts pain,stress, fatigue,and blood pressure in adults with rheumatoid arthritis

Among individuals with rheumatoid arthritis (RA), stress-associated disease flare can severely impact well-being. Psychological factors such as personal mastery may buffer an individual from the negative effects of those flares. We tested the hypothesis that a high sense of personal mastery would prospectively predict stress reactivity. Measures of pain, perceived stress, fatigue, and mean arterial pressure (MAP) were collected before, during, and after two interpersonal stressors conducted on 73 individuals with RA. Factor analysis of the personal mastery scale yielded two independent factors: a 5-item “fatalism” component and a 2-item “control” component. Individuals with high fatalism scores reported overall greater joint pain at baseline and those scoring high on control exhibited lower MAP, and reported less stress and fatigue at baseline. After controlling for baseline differences, those high in control exhibited greater MAP increase during stress, and less drop in pain when compared to those low in control. These results suggest that individuals high in control may be more susceptible to the effects of acute stress; however, the overall beneficial aspects of high control outweigh the acute negative effects. Personal mastery may play a role in the experience of pain, stress, and fatigue for people with RA.     

Understanding the impact of HIV diagnosis amongst gay men in Scotland: An interpretative phenomenological analysis

Objectives: Although a wide literature details the psychological impact of human immunodeficiency virus (HIV) diagnosis, it predates the introduction of effective treatment for HIV (i.e. anti-retroviral therapies, ARTs). This article explores the psychological impact of HIV diagnosis in post-ART accounts. This is important, given the recent policy developments which focus upon increasing HIV testing and thus diagnoses.

Design: This study presents a qualitative exploration of the experiential accounts of HIV-positive gay men living in Scotland. A total of 14 HIV-positive gay men took part in open-ended interviews.

Methods: Interpretative phenomenological analysis was employed to identify recurrent themes across the interviews.

Results: Our analysis focuses upon the participants’ struggles in adjusting to their HIV status. Diagnosis was a deeply shocking and unexpected experience. Stigma and fear of prejudice dominated their accounts. HIV was understood, variously, as a shameful, fatal and life-changing condition. Overall, within these accounts there was little sense of HIV normalisation.

Conclusions: In Scotland, where HIV prevalence is low, and where no accessible HIV-positive sub-culture exists, there is on-going psychological distress and morbidity amongst gay men testing HIV positive. As HIV-related policy increasingly focuses on increasing rates of antibody testing, there is a need to reduce the psychosocial costs associated with HIV-positive diagnoses.     

Time-Based Prospective Memory Performance and Time-Monitoring in Children with ADHD

The current study investigated prospective memory (PM) performance in children with attention deficit/hyperactivity disorder (ADHD) and controls and aimed at exploring possible underlying factors of PM performance. Twenty-two children with ADHD and 39 age- and ability-matched typically developing children performed a computerized time-based PM task. As predicted, children with ADHD had fewer correct PM responses than controls. Neither differences in overall ongoing task performance nor, remarkably, differences in overall frequency and accuracy of time monitoring were found. Exploratory analyses suggest that individual differences in time monitoring in the final interval before target times may be related to PM performance in ADHD.     

Motivation in Personal Construct Theory: A Conceptual Critique

Kelly's attempt to derive apparently motiwtional phenomena (hostility, guilt, etc.) solely from the confirmation or disconfirmation of personal constructs cannot adequately explain such phenomena. His account of hostility assumes that some beliefs are so resistant to change that the person seeks to compel confirmation of them; however, this resistance is incompatible with Kelly's own Choice Corollary. Anxiety is said to derive from the fact that disconfirmation would leave one's world in chaos, but “chaos” is shown to be an illogical concept. Humor, in turn, cannot be explained just by cognitive incongruity, since incongruity may as well lead to anxiety or hostility. Finally, guilt cannot be explained without reference to underlying fears of punishment and their rationalization in terms of supposedly objective moral concepts. Nevertheless, Kelly's Repertory Grid technique, supplemented by laddering, may be useful in indicating primary needs, moral convictions, and sources of anxiety.     

Going the distance: Extra-symbolic contributions to the symbolic control of spatial attention

Over the past 30 years, researchers have used symbolic cues such as spatial words and arrows to direct observers' attention to the location of target objects that appear at a single, fixed distance in simple visual environments; however, they have done so by using symbolic cues that provide only partial—directional—information about the spatial location of target objects. Thus, it remains unclear whether observers can only shift their attention broadly in the cued direction in response to these cues or whether they can shift their attention to the specific location of the target by combining an expectation about direction (derived from apprehension of the directional cue) with an expectation about distance (derived from some extra-symbolic cue). The results of two experiments showed that observers do shift their attention to relatively coarse spatial locations by combining expectancies about direction and distance, and that the extent to which observers do so is modulated by the presence of visible markers and the expected distance of the target. These findings are important because they provide the first evidence that extra-symbolic information about distance contributes to the symbolic control of spatial attention.