Functional cerebral changes in multiple sclerosis patients during an autobiographical memory test

Our aim was to investigate the functional underpinnings of autobiographical memory (AM) impairment in multiple sclerosis (MS) patients. To that end, 18 patients and 18 controls underwent the autobiographical interview (AI). Subsequently, the 36 participants underwent a functional magnetic resonance imaging (fMRI) session designed to assess the construction and elaboration of AMs. A categorical control task was also presented. Patients were trained in the fMRI procedure to optimise the procedural aspects accompanying the task itself. Although the patients obtained significantly poorer AI scores (p < .001), their performance on the easier AM fMRI task was efficiently carried out, allowing relevant comparisons with healthy controls. Relatively to healthy controls, the patients showed increased and bilateral cerebral activations (p < .005) during the construction and elaboration phases. The prefrontal, temporal and posterior cerebral region activations were located within the core network sustaining AM, with the bilateral prefrontal region being centrally involved. The parametric neural responses to the difficulty of access and amount of details of memories were also significantly different for the two groups, with the right hippocampal region showing a particularly increased recruitment (p < .005). The findings suggested the presence of functional cerebral changes during AM performance and supported the presence of AM retrieval deficit in MS patients.     

Interference Effects in Learning Similar Sequences of Discrete Movements

Three experiments were conducted to examine proactive and retroactive interference effects in learning 2 similar sequences of discrete movements. In each experiment, the participants in the experimental group practiced 2 movement sequences on consecutive days (1 on each day, order counterbalanced across participants) followed by retention tests on the third day. In all, 2 out of 8 target locations differed between the 2 sequences. Experiment 1 established the nature of the interference effects in the present setup. Clear evidence was found for button-specific proactive and retroactive interference effects. Experiments 2 and 3 further probed the mechanisms underlying those effects, by varying the numbers of repetitions (50 or 250) of the 1st and 2nd sequence (Experiment 2) and the hand, dominant or nondominant, with which the sequences were practiced (Experiment 3). Experiment 2 showed that after a mere 50 repetitions, the representation of the movement structure was strong enough to evoke the effects observed in Experiment 1. Experiment 3 revealed that learning with the dominant hand did not result in more pronounced interference effects compared with learning with the nondominant hand. In combination, these results suggest that changes in the representation of the movement structure are primarily responsible for the observed interference effects.     

Effect of a retention interval between pre-exposure and conditioning on latent inhibition in humans using a blink conditioning procedure

Latent inhibition, retarded learning after pre-exposure to the to-be-conditioned stimulus, was examined using a blink conditioned procedure in humans. Experiment 1 showed that the procedure is suited to inducing the latent inhibition effect. In Experiment 2, the introduction of a 3-minute interval between pre-exposure and conditioning phases attenuated latent inhibition. These results contribute to identify the mechanisms involved in pre-exposure and subsequent conditioning of a stimulus, which is particularly important if we bear in mind that latent inhibition has been used repeatedly as an instrument to analyze the course of attentional processes in normal and pathological populations.     

Gradual remapping results in early retinotopic and late spatiotopic inhibition of return

Here we report that immediately following the execution of an eye movement, oculomotor inhibition of return resides in retinotopic (eye-centered) coordinates. At longer postsaccadic intervals, inhibition resides in spatiotopic (world-centered) coordinates. These results are explained in terms of perisaccadic remapping. In the interval surrounding an eye movement, information is remapped within retinotopic maps to compensate for the retinal displacement. Because remapping is not an instantaneous process, a fast, but gradual, transfer of inhibition of return from retinotopic to spatiotopic coordinates can be observed in the postsaccadic interval. The observation that visual stability is preserved in inhibition of return is consistent with its function as a "foraging facilitator," which requires locations to be inhibited across multiple eye movements. The current results support the idea that the visual system is retinotopically organized and that the appearance of a spatiotopic organization is due to remapping of visual information to compensate for eye movements.     

A Direct Observation of the Dynamic Content and Structure of Coach-Athlete Interactions in a Model Sport Program

The purpose of this study was to analyze the coach-athlete interactions in a successful sport program for athletes with disabilities and their able-bodied siblings. The coach and 24 athletes were observed over multiple practice sessions. Measures of interaction content and structure were derived using state space grid (SSG) analysis. Results indicated that interactions were patterned and included behaviors such as individualized instruction, organization, and feedback. Interaction style changed according to the athletes’ competitive level, but no differences emerged based on disability status. This successful sport environment was characterized by patterned and positive coach-athlete interactions that were athlete, rather than disability-focused.     

How reaction time measures elucidate the matching bias and the way negations are processed

Matching bias refers to the non-normative performance that occurs when elements mentioned in a rule do not correspond with those in a test item (e.g., consider the double mismatch between the rule If there is a not a T on the card then there is not a 4 and a card showing H6). One aim of the present work is to capture matching bias via reaction times as participants carry out truth-table evaluation tasks. Experiment 1 requires participants to verify conditional rules, and Experiment 2 to falsify them as the paradigm (a) employs four types of conditional sentences that systematically rotate negatives in the antecedent and consequent; and (b) presents predominantly cases having true antecedents. These experiments reveal that mismatching is linked to higher rates of incorrect responses and slower evaluation times. A second aim is to investigate the way not is processed. We compare a narrow view of negations, which argues that negation only denies information (e.g., not-T only says there is no T), to a search for alternatives view, which says that negations function to prime appropriate alternatives (e.g., not-T primes a search for other letters). Findings from both experiments support a narrow reading view.     

Social Participation During Transition to Adult Life Among Young Adults With High-Functioning Autism Spectrum Disorders: Experiences From an Exploratory Multiple Case Study

This study aimed to explore the social participation of young adults with high-functioning autism spectrum disorders (HFASD) during their transition to adult life. A multiple case study was conducted using semi-structured interviews with a purposive sample of 10 participants (n = 10) composed of three adults with HFASD, their caregivers, and two representatives of community organizations. Four themes emerged: (1) access to services, (2) orientation to integrated life goals, (3) engagement in meaningful activities, and (4) gap in services before reaching independent living. Properly preparing and orienting the families could help them have a more satisfying social participation.     

Affective stimulus properties influence size perception and the Ebbinghaus illusion

In the New Look literature of the 1950s, it has been suggested that size judgments are dependent on the affective content of stimuli. This suggestion, however, has been 'discredited' due to contradictory findings and methodological problems. In the present study, we revisited this forgotten issue in two experiments. The first experiment investigated the influence of affective content on size perception by examining judgments of the size of target circles with and without affectively loaded (i.e., positive, neutral, and negative) pictures. Circles with a picture were estimated to be smaller than circles without a picture, and circles with a negative picture were estimated to be larger than circles with a positive or a neutral picture confirming the suggestion from the 1950s that size perception is influenced by affective content, an effect notably confined to negatively loaded stimuli. In a second experiment, we examined whether affective content influenced the Ebbinghaus illusion. Participants judged the size of a target circle whereby target and flanker circles differed in affective loading. The results replicated the first experiment. Additionally, the Ebbinghaus illusion was shown to be weakest for a negatively loaded target with positively loaded and blank flankers. A plausible explanation for both sets of experimental findings is that negatively loaded stimuli are more attention demanding than positively loaded or neutral stimuli.