Sex differences in behavioral consequences of defeat in the rat are not organized by testosterone during early development

Male and female rats react differently to losing an aggressive encounter, the presence of testosterone (at the time of confrontation) being a critical factor in the manifestation of this sex difference. Female rats were androgenized by 250 μg testosterone propionate sc on days 1 and 5 after birth. When adult they received a sc testosterone proprionate (TP) implant and were subjected to repeated defeats by being placed in the cage of an aggressive resident female. In contrast to males, which freeze and become permanently submissive, androgenized females showed no freezing or other signs of submission. The sex difference in response to defeat is therefore not dependent on the presence of testosterone during the period of post-natal sexual differentiation.     

Population growth and social structure of confined colonies of mongolian gerbils: Scent gland size and marking behaviour as indices of social status

Male gerbils have larger ventral scent glands, and they mark more than females. In both sexes, scent gland activity is dependent on gonadal hormones. Observations on colonies of gerbils, living in enclosures or cages, showed that both scent gland size and marking behaviour were related to social status. In colonies founded by a single pair, breeding was confined to the original female. The infertility of the daughters was due to failure of sexual maturation. As this was always associated with a lack of development of the scent glands, the functional state of the latter could be used as an index of fecundity. A change in social organization (eg removal of the parents) caused previously infertile females to conceive and was accompanied by development of the scent glands If there was competition for dominance, the scent glands of the losers regressed; at autopsy, their ovaries and uteri appeared to be nonfunctional. The founding father usually had a larger scent gland than his sons, but the inhibition of sexual function was not as severe as in the females. However, the father characteristically showed much more marking behaviow in a neutral territory than his sons. None of the fem ales-except the mother-showed appreciable marking, and her scores were much lower than those of the dominant male. Asymptotic populations were reached at about the same level in enclosures and cages, implicating an intrinsic capacity for control independent of the number of animals per unit of space but probably related to the natural size of a social group. Stabilization of numbers was achieved not only by reproductive inhibition of young females, but also by cessation of breeding by the founding mother and death of litters. Littermates raised in enclosures without their parents showed delayed sexual maturation accompanied by fighting which resulted in the formation of a hierarchy headed by a breeding female and a dominant (marking) male.     

Cooperative social coordination and aggression: Sex and strain differences in the effects of housing on gonadectomized rats with hormone replacement

Laboratory rats were used to investigate sex and strain differences in the effects of aggression on a cooperative behavior in which pairs learn to coordinate shuttling in a rectangular chamber. The level of aggression was manipulated by comparing males and females of the aggressive S3 strain and a less aggressive Sprague-Dawley-derived strain and by housing same-sex partners either together or individually (eight groups, n = 7 pairs per group). Hormone levels were stabilized by gonadectomy and daily injections of the appropriate sex hormone. The only serious coordination deficits were in individually housed males, associated with violent fighting and an extreme dominance/subordinance relationship that was not observed in females. All other groups readily learned and performed the coordination, with evidence that low and moderate levels of aggression could facilitate coordination by evoking species-typical behaviors that increased proximity, synchrony, and differentiation within pairs. The discussion focused on models of affiliative behavior in the study of aggression and the compatibility between moderate levels of aggression and cooperation.     

Cooperative social coordination and aggression: Sex and strain differences in the effects of housing on gonadectomized rats with hormone replacement

Laboratory rats were used to investigate sex and strain differences in the effects of aggression on a cooperative behavior in which pairs learned to coordinate shuttling in a rectangular chamber. The level of aggression was manipulated by comparing males and females of the aggressive S3 strain and a less aggressive Sprague-Dawley-derived strain and housing same-sex partners either together or individually (8 groups, n = 7 pairs per group). Hormone levels were stabilized by gonadectomy and daily injections of the appropriate sex hormone. The only serious coordination deficits were in individually housed males, associated with violent fighting and an extreme dominance/subordinance relationship that was not observed in females. All other groups readily learned and performed the coordination with evidence that low and moderate levels of aggression could facilitate coordination by evoking species-typical behaviors that increased proximity, synchrony, and differentiation within pairs. The discussion focused on models of affiliative behavior in the study of aggression and the compatibility between moderate levels of aggression and cooperation.     

Psychosocial Treatment Strategies in the MTA Study: Rationale, Methods, and Critical Issues in Design and Implementation

The Collaborative Multimodal Treatment Study of Children with Attention Deficit Hyperactivity Disorder (ADHD), the MTA, is the first multisite, cooperative agreement treatment study of children, and the largest psychiatric/psychological treatment trial ever conducted by the National Institute of Mental Health. It examines the effectiveness of Medication vs. Psychosocial treatment vs. their combination for treatment of ADHD and compares these experimental arms to each other and to routine community care. In a parallel group design, 579 (male and female) ADHD children, aged 7–9 years, 11 months, were randomly assigned to one of the four experimental arms, and then received 14 months of prescribed treatment (or community care) with periodic reassessments. After delineating the theoretical and empirical rationales for Psychosocial treatment of ADHD, we describe the MTA's Psychosocial Treatment strategy applied to all children in two of the four experimental arms (Psychosocial treatment alone; Combined treatment). Psychosocial treatment consisted of three major components: a Parent Training component, a two-part School Intervention component, and a child treatment component anchored in an intensive Summer Treatment Program. Components were selected based on evidence of treatment efficacy and because they address comprehensive symptom targets, settings, comorbidities, and functional domains. We delineate key conceptual and logistical issues faced by clinical researchers in design and implementation of Psychosocial research with examples of how these issues were addressed in the MTA study.Deceased     

Family Processes and Treatment Outcome in the MTA: Negative/Ineffective Parenting Practices in Relation to Multimodal Treatment

To elucidate processes underlying therapeutic change in a large-scale randomized clinical trial, we examined whether alterations in self-reported parenting practices were associated with the effects of behavioral, medication, or combination treatments on teacher-reported outcomes (disruptive behavior, social skills, internalizing symptoms) in children with attention-deficit hyperactivity disorder (ADHD). Participants were 579 children with Combined-type ADHD, aged 7–9.9 years, in the Multimodal Treatment Study of Children with ADHD (MTA). We uncovered 2 second-order factors of parenting practices, entitled Positive Involvement and Negative/Ineffective Discipline. Although Positive Involvement was not associated with amelioration of the school-based outcome measures, reductions in Negative/Ineffective Discipline mediated improvement in children's social skills at school. For families showing the greatest reductions in Negative/Ineffective Discipline, effects of combined medication plus behavioral treatment were pronounced in relation to regular community care. Furthermore, only in combination treatment (and not in behavioral treatment alone) was decreased Negative/Ineffective Discipline associated with reduction in children's disruptive behavior at school. Here, children in families receiving combination treatment who showed the greatest reductions in Negative/Ineffective Discipline had teacher-reported disruptive behavior that was essentially normalized. Overall, the success of combination treatment for important school-related outcomes appears related to reductions in negative and ineffective parenting practices at home; we discuss problems in interpreting the temporal sequencing of such process-outcome linkages and the means by which multimodal treatment may be mediated by psychosocial processes related to parenting.     

Parenting and Family Stress Treatment Outcomes in Attention Deficit Hyperactivity Disorder (ADHD): An Empirical Analysis in the MTA Study

Parenting and family stress treatment outcomes in the MTA study were examined. Male and female (579), 7–9-year-old children with combined type Attention Deficit Hyperactivity Disorder (ADHD), were recruited at six sites around the United States and Canada, and randomly assigned to one of four groups: intensive, multi-faceted behavior therapy program alone (Beh); carefully titrated and monitored medication management strategy alone (MedMgt); a well-integrated combination of the two (Comb); or a community comparison group (CC). Treatment occurred over 14 months, and assessments were taken at baseline, 3, 9, and 14 months. Parenting behavior and family stress were assessed using parent-report and child-report inventories. Results showed that Beh alone, MedMgt alone, and Comb produced significantly greater decreases in a parent-rated measure of negative parenting, Negative/Ineffective Discipline, than did standard community treatment. The three MTA treatments did not differ significantly from each other on this domain. No differences were noted among the four groups on positive parenting or on family stress variables. Results are discussed in terms of the theoretical and empirically documented importance of negative parenting in the symptoms, comorbidities and long-term outcomes of ADHD.     

Anger and postcombat mental health: Validation of a brief anger measure with U.S. Soldiers postdeployed from Iraq and Afghanistan

The involvement of anger in the psychological adjustment of current war veterans, particularly in conjunction with combat-related posttraumatic stress disorder (PTSD), warrants greater research focus than it has received. The present study concerns a brief anger measure, Dimensions of Anger Reactions (DAR), intended for use in large sample studies and as a screening tool. The concurrent validity, discriminant validity, and incremental validity of the instrument were examined in conjunction with behavioral health data for 3,528 treatment-seeking soldiers who had been in combat in Iraq and Afghanistan. Criterion indices included multiple self-rated measures of psychological distress (including PTSD, depression, and anxiety), functional difficulties (relationships, daily activities, work problems, and substance use), and violence risk. Concurrent validity was established by strong correlations with single anger items on 4 other scales, and discriminant validity was found against anxiety and depression measures. Pertinent to the construct of anger, the DAR was significantly associated with psychosocial functional difficulties and with several indices of harm to self and to others. Hierarchical regression performed on a self/others harm index found incremental validity for the DAR, controlling for age, education, military component, officer rank, combat exposure, PTSD, and depression. The ability to efficiently assess anger in at-risk military populations can provide an indicator of many undesirable behavioral health outcomes. (PsycINFO Database Record (c) 2012 APA, all rights reserved).