McEwen-Induced Modulation of Endocrine History: A Partial Review

In endless facets of physiology, there are points of homeostatic balance, such that too much or too litttle of something can both be deleterious (i.e., an "inverse U" pattern). This is particularly true when considering glucocorticoids (GCs), the adrenals steroid secreted during stress. In the first part of this paper, I review a number of realms in which a paucity and an excess of GCs are both damaging. Some findings are classical (for example, concerning GC effects upon body weight), while some are quite recent and have considerable implications for both physiology and pathophysiology (for example, inverse U's of GC actions in the realm of immunity and neuronal survival). The second part of the review considers the far thornier issue of how such inverse U's of GC actions are generated on a cellular and molecular level. One solution that has evolved, primarily in the hippocampus within the nervous system, involves the presence of two different types of receptors for GCs within the same cells; so long as the two receptors have very different affinities and mediate opposing effects on some cellular endpoint, an inverse U will emerge. The second solution, found in a number of peripheral tissues, involves GCs having opposing effects on the amount of some signal being generated (e.g., an immune cytokine) and the sensitivity of target tissues to that signal; under conditions that appear to be physiologically relevant, inverse U's emerge from this pattern as well. The final section of this review considers the enormous role played by Bruce McEwen in the emergence of this literature. I suggest that while much of this obviously has to do with the facts that have come from his group, another substantial contribution is from his steadying and supportive personality, the veritable embodiment of homeostatic balance.     

Reacting to reactance: An Interpersonal interpretation of the need for freedom

This study was designed to investigate the conditions under which the negative consequences of social influence attempts can be mitigated by freedom-affirming interventions. Eighty-eight high school girls received an influence message, presumably written by a co-worker, containing either a threat or a promise. In addition, subjects were or were not given a choice option as to mode of compliance, if they chose to comply with the message. In half the cases, the Interpersonal condition, subjects received their choice/no choice option from their co-worker; in the other half of the cases, the Noninterpersonal condition, subjects were assigned the choice/no choice option by a random event unknown to the influencing agent. As anticipated, in the Interpersonal as compared to the Noninterpersonal condition, (a) threats produced greater compliance when a choice was offered than when it was not, and (b) promises and threats were more equivalent in gaining compliance when a choice was offered than when it was not. These results, which suggest that in a social setting individuals' concerns about freedom are interpersonally motivated, are discussed in terms of their relation to and implications for reactance theory.     

Impaired acquisition of temporal information in retrosplenial amnesia

In this paper we describe the performance of an amnesic with a left retrosplenial lesion on three memory tasks assessing his ability to judge when a previously learned event had occurred. This patient was dramatically impaired in acquiring temporal information about new stimuli, and this defect could not be attributed to recognition failures or to frontal lobe dysfunction. In contrast to his impaired acquisition of temporal information, he had no difficulty judging the temporal order of remote historical events. The pattern of performance displayed by this patient suggests a specific defect in "time-tagging" of new incoming information.     

Letter imagery deficits in a case of pure apraxic agraphia

Pure apraxic agraphia is a condition in which motor writing is impaired but limb praxis and nonmotor writing (typing, anagram letters) are preserved. This condition is believed to result from disruption of a parietal lobe graphemic area which generates grapheme representations used to program motor-writing patterns. We report a single case of pure apraxic agraphia in which defective letter imagery was evident. Results of writing and imagery evaluations suggest that the graphemic area may be responsible for generating letter images. In this respect, clinical evaluation of letter imagery abilities in cases of apraxic agraphia may be useful in identifying subtypes of the disorder resulting in a better understanding of the neuropsychological process involved in writing.     

Affective aprosodia from a medial frontal stroke

BACKGROUND AND OBJECTIVES: Whereas injury to the left hemisphere induces aphasia, injury to the right hemisphere's perisylvian region induces an impairment of emotional speech prosody (affective aprosodia). Left-sided medial frontal lesions are associated with reduced verbal fluency with relatively intact comprehension and repetition (transcortical motor aphasia), but persistent affective prosodic defects associated with right medial frontal lesions have not been described. METHODS: We assessed the prosody of a man who sustained a right medial frontal cerebral infarction seven years prior. RESULTS: While propositional speech expression was normal including syntactic prosody, the patient was impaired at expressing emotions using prosody. His comprehension and repetition of prosody were also impaired but less so than expression. CONCLUSIONS: Right medial frontal lesions can induce an affective aprosodia that primarily impairs expression.     

The effects of focal and global attentional systems on spatial biases

The background page on which a stimulus is presented can influence the allocation of attention to that stimulus. The purpose of this study was to learn if there are hemispheric asymmetries in how background distraction affects attentional processing. Asymmetries were investigated by having right eye dominant subjects perform line bisections and manipulating the side of background distraction (right versus left), the eye of regard (right versus left), and the type of attention allocated (focal versus global). Overall subjects bisected lines to the left of center (pseudoneglect) and when viewing with the right eye (versus left) deviated more to the left. Subjects had more background distraction when viewing symbol than solid lines. Although overall, bias did not differ with the side of background distraction or the line being on one side or the other, when subjects viewed symbol, but not solid lines, this leftward bias was increased when the line was displaced to the right, thereby increasing the size of the left sided background. These findings suggest that when engaging the left hemisphere by using focused attention and placing the line on the right side, there is more distraction than when the right hemisphere is engaged.     

Hemihypokinesia after right hemisphere stroke

We tested the hypothesis that the right hemisphere is dominant for motor activation of "intention." If the right hemisphere is dominant for intention and if intention is a prerequisite for movement, motor impairment should be worse after an infarct in the right hemisphere than in the left. We asked nine subjects with right and nine with left hemisphere infarcts to elevate each shoulder independently. Subjects with right hemisphere lesions had more trouble moving the contralateral shoulder. The data are consistent with the hypothesis that the right hemisphere is dominant for motor activation or intention.     

Defects of immediate memory in Broca's and conduction aphasia

It has been suggested that the repetition defect seen in conduction aphasia is caused by an auditory immediate memory defect. The purposes of this study were the following: to ascertain whether the finding of an auditory immediate memory defect in conduction aphasia could be replicated, to ascertain whether Broca's aphasics have a similar type of immediate memory defect, and to ascertain whether a relationship exists between immediate memory and comprehension of spoken language. Digits were either spoken or presented visually to Broca's and conduction aphasics. An analysis of span scores reveals that within each group there were no significant differences between the modes of presentation or the response modes. There were no significant differences between the aphasic groups. Comprehension of spoken language significantly correlated with digit span scores.     

Footsteps I would like to follow? How gender quotas affect the acceptance of women leaders as role models and inspirations for leadership

This research examines how the method of selecting women leaders affects other women's leadership interest. The results of three experiments (N = 1,015) indicated that only when women leaders were selected due to merit, not quota-based policies, did they boost female participants’ interest in a leadership position. These reactions were mediated by perceptions of the woman leader's deservingness of her position (Studies 1–3) and consequent acceptance as a role model (Studies 2 and 3). Accordingly, success information validating quota-based selected leaders’ competence provided a boost in leadership interest equal to that of merit-based selected leaders (Study 2). For male participants, quota but not merit-based selected women leaders lowered interest in leadership due to their pessimistic assessment of the probability of being selected (Study 1). These results suggest that a wise implementation of quota regulations includes validating women's competence so they are perceived as deserving of their leader roles and can thus serve as inspiring role models.